IGHG_RABIT
ID IGHG_RABIT Reviewed; 323 AA.
AC P01870;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Ig gamma chain C region;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6313520; DOI=10.1007/bf00372471;
RA Bernstein K.E., Alexander C.B., Mage R.G.;
RT "Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I
RT haplotype.";
RL Immunogenetics 18:387-397(1983).
RN [2]
RP PROTEIN SEQUENCE OF 1-128.
RX PubMed=1243651; DOI=10.1042/bj1510337;
RA Pratt D.M., Mole L.E.;
RT "Sequence studies on the constant region of the Fd sections of rabbit
RT immunoglobulin G of different allotype.";
RL Biochem. J. 151:337-349(1975).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 88-266.
RX PubMed=6193512; DOI=10.1073/pnas.79.19.6018;
RA Martens C.L., Moore K.W., Steinmetz M., Hood L., Knight K.L.;
RT "Heavy chain genes of rabbit IgG: isolation of a cDNA encoding gamma heavy
RT chain and identification of two genomic C gamma genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:6018-6022(1982).
RN [4]
RP PROTEIN SEQUENCE OF 132-161.
RX PubMed=5461106; DOI=10.1042/bj1160249;
RA Fruchter R.G., Jackson S.A., Mole L.E., Porter R.R.;
RT "Sequence studies of the Fd section of the heavy chain of rabbit
RT immunoglobulin G.";
RL Biochem. J. 116:249-259(1970).
RN [5]
RP PROTEIN SEQUENCE OF 129-131 AND 155-322.
RA Hill R.L., Lebovitz H.E., Fellows R.E. Jr., Delaney R.;
RL (In) Killander J. (eds.);
RL Gamma globulins, Nobel symp. 3, pp.109-127, Almqvist and Wiksell, Stockholm
RL (1967).
CC -!- MISCELLANEOUS: PubMed:6313520 sequence has the D12 allotypic marker,
CC 104-Thr, and the E14 marker, 185-Thr. PubMed:6193512 has the D11 and
CC E15 markers and Ref.5 the E15 marker.
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DR EMBL; M16426; AAA31289.1; -; mRNA.
DR PIR; A91749; GHRB.
DR PDB; 2VUO; X-ray; 1.95 A; A/B=105-323.
DR PDB; 5DTF; X-ray; 1.90 A; A/H=1-104.
DR PDBsum; 2VUO; -.
DR PDBsum; 5DTF; -.
DR AlphaFoldDB; P01870; -.
DR SMR; P01870; -.
DR PRIDE; P01870; -.
DR ABCD; P01870; 4 sequenced antibodies.
DR EvolutionaryTrace; P01870; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IPI:AgBase.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 3.
DR SMART; SM00407; IGc1; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Immunoglobulin domain;
KW Reference proteome; Repeat.
FT CHAIN <1..323
FT /note="Ig gamma chain C region"
FT /id="PRO_0000153595"
FT DOMAIN 6..96
FT /note="Ig-like 1"
FT DOMAIN 114..213
FT /note="Ig-like 2"
FT DOMAIN 222..318
FT /note="Ig-like 3"
FT VARIANT 104
FT /note="T -> M (in D11 marker)"
FT VARIANT 185
FT /note="T -> A (in E15 marker)"
FT CONFLICT 48
FT /note="N -> E (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="V -> VPV (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="Q -> E (in Ref. 3 and 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="N -> D (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="Q -> E (in Ref. 3 and 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="N -> D (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="Q -> E (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="E -> Q (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="N -> D (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="E -> G (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="N -> D (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="N -> D (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="Y -> W (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="N -> S (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT NON_TER 1
FT STRAND 7..11
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 22..35
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:5DTF"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 63..72
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 78..84
FT /evidence="ECO:0007829|PDB:5DTF"
FT HELIX 85..87
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:5DTF"
FT STRAND 115..119
FT /evidence="ECO:0007829|PDB:2VUO"
FT HELIX 123..127
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 134..142
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 150..155
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 167..170
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 176..183
FT /evidence="ECO:0007829|PDB:2VUO"
FT HELIX 186..190
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 195..200
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 208..212
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 223..227
FT /evidence="ECO:0007829|PDB:2VUO"
FT HELIX 231..235
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 236..251
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 254..259
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 262..264
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 267..269
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 280..289
FT /evidence="ECO:0007829|PDB:2VUO"
FT HELIX 290..294
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 299..304
FT /evidence="ECO:0007829|PDB:2VUO"
FT HELIX 309..311
FT /evidence="ECO:0007829|PDB:2VUO"
FT STRAND 312..317
FT /evidence="ECO:0007829|PDB:2VUO"
SQ SEQUENCE 323 AA; 35404 MW; 69E8AA118D579A8B CRC64;
GQPKAPSVFP LAPCCGDTPS STVTLGCLVK GYLPEPVTVT WNSGTLTNGV RTFPSVRQSS
GLYSLSSVVS VTSSSQPVTC NVAHPATNTK VDKTVAPSTC SKPTCPPPEL LGGPSVFIFP
PKPKDTLMIS RTPEVTCVVV DVSQDDPEVQ FTWYINNEQV RTARPPLREQ QFNSTIRVVS
TLPITHQDWL RGKEFKCKVH NKALPAPIEK TISKARGQPL EPKVYTMGPP REELSSRSVS
LTCMINGFYP SDISVEWEKN GKAEDNYKTT PAVLDSDGSY FLYNKLSVPT SEWQRGDVFT
CSVMHEALHN HYTQKSISRS PGK
