IGHM_CHICK
ID IGHM_CHICK Reviewed; 446 AA.
AC P01875;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Ig mu chain C region;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 80-446.
RX PubMed=6310496; DOI=10.1093/nar/11.16.5381;
RA Dahan A., Reynaud C.-A., Weill J.-C.;
RT "Nucleotide sequence of the constant region of a chicken mu heavy chain
RT immunoglobulin mRNA.";
RL Nucleic Acids Res. 11:5381-5389(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-79.
RA Weill J.-C.;
RL Submitted (MAR-1986) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; X01613; CAA25762.1; -; mRNA.
DR PIR; A02170; MHCH.
DR AlphaFoldDB; P01875; -.
DR SMR; P01875; -.
DR VEuPathDB; HostDB:LOC107051274; -.
DR PhylomeDB; P01875; -.
DR Reactome; R-GGA-2132263; Creation of classical C3 convertase.
DR Reactome; R-GGA-2132286; Classical antibody-mediated complement activation.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:AgBase.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF07654; C1-set; 2.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF00047; ig; 1.
DR SMART; SM00407; IGc1; 2.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome.
FT CHAIN <1..446
FT /note="Ig mu chain C region"
FT /id="PRO_0000153618"
FT REGION 1..105
FT /note="CH1"
FT REGION 106..209
FT /note="CH2"
FT REGION 210..316
FT /note="CH3"
FT REGION 317..427
FT /note="CH4"
FT REGION 428..446
FT /note="C-terminal region"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 16
FT /note="Interchain (with a light chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 27..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 135..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 237..296
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 284
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 344..406
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 445
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 1
SQ SEQUENCE 446 AA; 48174 MW; 3CB0CE108949BD17 CRC64;
ASASPSPPRL FPLVLCSPSD SVYTVGCAAF DFQPSSIAFT WFDSNNSSVS GMDVIPKVIS
GPPYRAVSRI QMNQSEGKEK QPFRCRAAHP RGNVEVSVMN PGPIPTPNGI PLFVTMHPPS
REDFEGPFRN ASILCQTRGR RRPTEVTWYK NGSPVAAAAT TATTVGPEVV AESRISVTES
EWDTGATFSC VVEGEMRNTS KRMECGLEPV VQQDIAIRVI TPSFVDIFIS KSATLTCRVS
NMVNADGLEV SWWKEKGGKL ETALGKRVLQ SNGLYTVDGV ATVCASEWDG GDGYVCKVNH
PDLLFPMEEK MRKTKASNAR PPSVYVFPPP TEQLNGNQRL SVTCMAQGFN PPHLFVRWMR
NGEPLPQSQS VTSAPMAENP ENESYVAYSV LGVGAEEWGA GNVYTCLVGH EALPLQLAQK
SVDRASGKAS AVNVSLVLAD SAAACY
