ID   IGHM_RABIT              Reviewed;         458 AA.
AC   P03988;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-1986, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Ig mu chain C region secreted form;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (A2 ALLOTYPE).
RX   PubMed=6418803;
RA   Bernstein K.E., Alexander C.B., Reddy E.P., Mage R.G.;
RT   "Complete sequence of a cloned cDNA encoding rabbit secreted mu-chain of
RT   VHa2 allotype: comparisons with VHa1 and membrane mu sequences.";
RL   J. Immunol. 132:490-495(1984).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=During differentiation, B-lymphocytes switch from expression
CC         of isoform Membrane-bound to isoform Secreted.;
CC       Name=Secreted;
CC         IsoId=P03988-1; Sequence=Displayed;
CC       Name=Membrane-bound;
CC         IsoId=P04221-1; Sequence=External;
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DR   EMBL; K01357; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A02164; MHRB.
DR   AlphaFoldDB; P03988; -.
DR   SMR; P03988; -.
DR   PRIDE; P03988; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF07654; C1-set; 3.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00407; IGc1; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Reference proteome; Secreted.
FT   CHAIN           <1..458
FT                   /note="Ig mu chain C region secreted form"
FT                   /id="PRO_0000153625"
FT   REGION          1..106
FT                   /note="CH1"
FT   REGION          107..222
FT                   /note="CH2"
FT   REGION          223..327
FT                   /note="CH3"
FT   REGION          328..458
FT                   /note="CH4"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        445
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        14
FT                   /note="Interchain (with light chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        28..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        137..200
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        219
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        249..308
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        296
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        356..418
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   458 AA;  49897 MW;  F338D6A3B28E4864 CRC64;
     VSLSSPTLYP LVSCEGALTD GNLVAMGCLA RDFLPSSVTF SWSFKNNSEI SSRTVRTFPV
     VKRGDKYMAT SQVLVPSKDV LQGTEEYLVC KVQHSNSNRD LRVSFPVDSE LPPNVSVFIP
     PRDSFSGSGT RKSRLICQAT GFSPKQISVS WLRDGQKVES GVLTKPVEAE TKGAGPATFS
     ISSMLTITES DWLSQSLYTC RVDHRGIFFD KNVSMSSECS TTPSPGIQVF PIAPSFADTF
     LSKSARLICL VTDLTTYGSL NISWASHNGK ALDTHMNITE SHPNATFSAM GEASVCAEDW
     ESGEQFTCTV THADLPFPLK HTISKSREVA KHPPAVYVLP PAREQLVLRE SATVTCLVKG
     FSPADVFVQW QQRGQPLSSD KYVTSAPAPE PQAPGLYFTH STLTVTEEDW NSGETFTCVV
     GHEALPHMVT ERTVDKSTGK PTLYNVSLIM SDTASTCY