ID   IGIP_BOVIN              Reviewed;          47 AA.
AC   P0C7I2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=IgA-inducing protein;
DE   Flags: Precursor;
GN   Name=IGIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=12874223; DOI=10.4049/jimmunol.171.3.1336;
RA   Austin A.S., Haas K.M., Naugler S.M., Bajer A.A., Garcia-Tapia D.,
RA   Estes D.M.;
RT   "Identification and characterization of a novel regulatory factor: IgA-
RT   inducing protein.";
RL   J. Immunol. 171:1336-1342(2003).
CC   -!- FUNCTION: Enhances IgA secretion from B-cells stimulated via CD40.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12874223}.
CC   -!- TISSUE SPECIFICITY: Expressed in Peyer patches, spleen, thymus, liver
CC       and mesenteric lymph node. Expressed at high levels by dendritic cells,
CC       and at lower levels by T-cells, monocytes and B-cells.
CC       {ECO:0000269|PubMed:12874223}.
CC   -!- INDUCTION: By CD40 stimulation in dendritic cells (at protein level).
CC       {ECO:0000269|PubMed:12874223}.
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DR   EMBL; AF173827; AAG16763.1; -; mRNA.
DR   RefSeq; NP_991340.1; NM_205771.2.
DR   AlphaFoldDB; P0C7I2; -.
DR   STRING; 9913.ENSBTAP00000035241; -.
DR   PaxDb; P0C7I2; -.
DR   Ensembl; ENSBTAT00000035366; ENSBTAP00000035241; ENSBTAG00000025226.
DR   GeneID; 404059; -.
DR   KEGG; bta:404059; -.
DR   CTD; 492311; -.
DR   VEuPathDB; HostDB:ENSBTAG00000025226; -.
DR   VGNC; VGNC:55213; IGIP.
DR   eggNOG; ENOG502TDWN; Eukaryota.
DR   GeneTree; ENSGT00390000001137; -.
DR   HOGENOM; CLU_3068056_0_0_1; -.
DR   InParanoid; P0C7I2; -.
DR   OrthoDB; 1624806at2759; -.
DR   TreeFam; TF341188; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000025226; Expressed in pons and 98 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038815; IGIP.
DR   PANTHER; PTHR39224; PTHR39224; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..47
FT                   /note="IgA-inducing protein"
FT                   /id="PRO_0000332152"
SQ   SEQUENCE   47 AA;  5072 MW;  C6E4DF6A56147267 CRC64;
     MKKRSVSGCN ITILAVVFSH LSAGNSPCGN QANVLCISRL EFVQYQS