ID   IGIP_HUMAN              Reviewed;          53 AA.
AC   A6NJ69;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=IgA-inducing protein homolog;
DE   Flags: Precursor;
GN   Name=IGIP; Synonyms=C5orf53;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
CC   -!- FUNCTION: Enhances IgA secretion from B-cells stimulated via CD40.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC011379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS34244.1; -.
DR   RefSeq; NP_001007190.1; NM_001007189.1.
DR   AlphaFoldDB; A6NJ69; -.
DR   BioGRID; 138896; 2.
DR   IntAct; A6NJ69; 1.
DR   STRING; 9606.ENSP00000327344; -.
DR   BioMuta; IGIP; -.
DR   PaxDb; A6NJ69; -.
DR   PRIDE; A6NJ69; -.
DR   Antibodypedia; 62605; 16 antibodies from 7 providers.
DR   DNASU; 492311; -.
DR   Ensembl; ENST00000333305.5; ENSP00000327344.3; ENSG00000182700.5.
DR   GeneID; 492311; -.
DR   KEGG; hsa:492311; -.
DR   MANE-Select; ENST00000333305.5; ENSP00000327344.3; NM_001007189.2; NP_001007190.1.
DR   UCSC; uc003lfb.2; human.
DR   CTD; 492311; -.
DR   GeneCards; IGIP; -.
DR   HGNC; HGNC:33847; IGIP.
DR   HPA; ENSG00000182700; Tissue enhanced (brain).
DR   neXtProt; NX_A6NJ69; -.
DR   PharmGKB; PA164717341; -.
DR   VEuPathDB; HostDB:ENSG00000182700; -.
DR   eggNOG; ENOG502TDWN; Eukaryota.
DR   GeneTree; ENSGT00390000001137; -.
DR   HOGENOM; CLU_3068056_0_0_1; -.
DR   InParanoid; A6NJ69; -.
DR   OMA; LCSYYHM; -.
DR   OrthoDB; 1624806at2759; -.
DR   PhylomeDB; A6NJ69; -.
DR   TreeFam; TF341188; -.
DR   PathwayCommons; A6NJ69; -.
DR   SignaLink; A6NJ69; -.
DR   BioGRID-ORCS; 492311; 12 hits in 1059 CRISPR screens.
DR   ChiTaRS; IGIP; human.
DR   GenomeRNAi; 492311; -.
DR   Pharos; A6NJ69; Tdark.
DR   PRO; PR:A6NJ69; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A6NJ69; protein.
DR   Bgee; ENSG00000182700; Expressed in hypothalamus and 94 other tissues.
DR   ExpressionAtlas; A6NJ69; baseline and differential.
DR   Genevisible; A6NJ69; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038815; IGIP.
DR   PANTHER; PTHR39224; PTHR39224; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..53
FT                   /note="IgA-inducing protein homolog"
FT                   /id="PRO_0000332153"
SQ   SEQUENCE   53 AA;  5937 MW;  3DF387501660E00C CRC64;
     MCSYYHMKKR SVSGCNITIF AVMFSHLSAG KSPCGNQANV LCISRLEFVQ YQS