ID   IGJ_RABIT               Reviewed;         136 AA.
AC   P23108;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Immunoglobulin J chain;
GN   Name=JCHAIN {ECO:0000250|UniProtKB:P01591}; Synonyms=IGJ;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2123094; DOI=10.1042/bj2710641;
RA   Hughes G.J., Frutiger S., Paquet N., Jaton J.-C.;
RT   "The amino acid sequence of rabbit J chain in secretory immunoglobulin A.";
RL   Biochem. J. 271:641-647(1990).
CC   -!- FUNCTION: Serves to link two monomer units of either IgM or IgA. In the
CC       case of IgM, the J chain-joined dimer is a nucleating unit for the IgM
CC       pentamer, and in the case of IgA it induces dimers and/or larger
CC       polymers. It also helps to bind these immunoglobulins to secretory
CC       component. {ECO:0000250|UniProtKB:P01592}.
CC   -!- SUBUNIT: Part of the secretory IgA (sIgA) complex that consists of two,
CC       four or five IgA monomers, and two additional non-Ig polypeptides,
CC       namely the JCHAIN and the secretory component (the proteoytic product
CC       of PIGR). {ECO:0000250|UniProtKB:P01591}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01592}.
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DR   PIR; S13049; S13049.
DR   AlphaFoldDB; P23108; -.
DR   SMR; P23108; -.
DR   STRING; 9986.ENSOCUP00000023316; -.
DR   eggNOG; ENOG502RZF4; Eukaryota.
DR   InParanoid; P23108; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0071751; C:secretory IgA immunoglobulin complex; ISS:UniProtKB.
DR   InterPro; IPR024110; Ig_J.
DR   PANTHER; PTHR10070; PTHR10070; 1.
DR   Pfam; PF15097; Ig_J_chain; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted.
FT   CHAIN           1..136
FT                   /note="Immunoglobulin J chain"
FT                   /id="PRO_0000084175"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) (complex) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
FT   DISULFID        12..100
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
FT   DISULFID        14
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
FT   DISULFID        68
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
FT   DISULFID        71..91
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
FT   DISULFID        108..133
FT                   /evidence="ECO:0000250|UniProtKB:P01591"
SQ   SEQUENCE   136 AA;  15556 MW;  9CFF2677BDCFC7B4 CRC64;
     EDESTVLVDN KCQCVRITSR IIRDPDNPSE DIVERNIRII VPLNTRENIS DPTSPLRTEF
     KYNLANLCKK CDPTEIELDN QVFTASQSNI CPDDDYSETC YTYDRNKCYT TLVPITHRGG
     TRMVKATLTP DSCYPD