IGKC_MOUSE
ID IGKC_MOUSE Reviewed; 107 AA.
AC P01837; A0A075B5P2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Immunoglobulin kappa constant {ECO:0000250|UniProtKB:P01834};
DE AltName: Full=Ig kappa chain C region MOPC 21 {ECO:0000303|PubMed:4638343};
GN Name=Igkc {ECO:0000312|MGI:MGI:96495};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=4638343; DOI=10.1042/bj1280427;
RA Svasti J., Milstein C.;
RT "The complete amino acid sequence of a mouse kappa light chain.";
RL Biochem. J. 128:427-444(1972).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 54-60.
RX PubMed=103625; DOI=10.1016/0092-8674(78)90290-8;
RA Hamlyn P.H., Brownlee G.G., Cheng C.-C., Gait M.J., Milstein C.;
RT "Complete sequence of constant and 3' noncoding regions of an
RT immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing.";
RL Cell 15:1067-1075(1978).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6170937; DOI=10.1093/nar/9.18.4485;
RA Hamlyn P.H., Gait M.J., Milstein C.;
RT "Complete sequence of an immunoglobulin mRNA using specific priming and the
RT dideoxynucleotide method of RNA sequencing.";
RL Nucleic Acids Res. 9:4485-4494(1981).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6262318; DOI=10.1016/s0021-9258(19)69374-9;
RA Max E.E., Maizel J.V. Jr., Leder P.;
RT "The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse
RT kappa immunoglobulin J and C region genes.";
RL J. Biol. Chem. 256:5116-5120(1981).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3138116; DOI=10.1111/j.1432-1033.1988.tb14280.x;
RA de Waele P., Feys V., van de Voorde A., Molemans F., Fiers W.;
RT "Expression in non-lymphoid cells of mouse recombinant immunoglobulin
RT directed against the tumour marker human placental alkaline phosphatase.";
RL Eur. J. Biochem. 176:287-295(1988).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-107.
RX PubMed=6775818; DOI=10.1016/0092-8674(80)90168-3;
RA Hieter P.A., Max E.E., Seidman J.G., Maizel J.V. Jr., Leder P.;
RT "Cloned human and mouse kappa immunoglobulin constant and J region genes
RT conserve homology in functional segments.";
RL Cell 22:197-207(1980).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-107.
RX PubMed=6785724; DOI=10.1093/nar/9.4.971;
RA Altenburger W., Neumaier P.S., Steinmetz M., Zachau H.G.;
RT "DNA sequence of the constant gene region of the mouse immunoglobulin kappa
RT chain.";
RL Nucleic Acids Res. 9:971-981(1981).
RN [9]
RP DISULFIDE BONDS.
RX PubMed=5073237; DOI=10.1042/bj1260837;
RA Svasti J., Milstein C.;
RT "The disulphide bridges of a mouse immunoglobulin G1 protein.";
RL Biochem. J. 126:837-850(1972).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; V00807; CAA24189.1; -; Genomic_DNA.
DR EMBL; AC153612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; B90262; K1MS.
DR PDB; 15C8; X-ray; 2.50 A; L=1-105.
DR PDB; 1A0Q; X-ray; 2.30 A; L=1-106.
DR PDB; 1A3L; X-ray; 1.95 A; L=1-105.
DR PDB; 1AHW; X-ray; 3.00 A; A/D=1-107.
DR PDB; 1AI1; X-ray; 2.80 A; L=1-104.
DR PDB; 1AIF; X-ray; 2.90 A; A/L=1-107.
DR PDB; 1C12; X-ray; 2.60 A; A=1-106.
DR PDB; 1CF8; X-ray; 2.70 A; L=1-107.
DR PDB; 1CFN; X-ray; 2.65 A; A=1-107.
DR PDB; 1CFQ; X-ray; 2.80 A; A=1-107.
DR PDB; 1CFS; X-ray; 2.75 A; A=1-107.
DR PDB; 1CFT; X-ray; 2.80 A; A=1-107.
DR PDB; 1CIC; X-ray; 2.50 A; A=1-107.
DR PDB; 1CK0; X-ray; 2.50 A; L=1-104.
DR PDB; 1CT8; X-ray; 2.20 A; A/C=1-107.
DR PDB; 1DQJ; X-ray; 2.00 A; A=1-107.
DR PDB; 1DQM; X-ray; 2.10 A; L=1-107.
DR PDB; 1DQQ; X-ray; 1.80 A; A/C=1-107.
DR PDB; 1E4W; X-ray; 1.95 A; L=1-107.
DR PDB; 1E4X; X-ray; 1.90 A; L/M=1-107.
DR PDB; 1EHL; X-ray; 2.40 A; L=1-106.
DR PDB; 1EMT; X-ray; 2.25 A; L=1-107.
DR PDB; 1F11; X-ray; 3.00 A; A/C=2-107.
DR PDB; 1FAI; X-ray; 2.70 A; L=1-107.
DR PDB; 1FBI; X-ray; 3.00 A; L/P=1-107.
DR PDB; 1FDL; X-ray; 2.50 A; L=1-107.
DR PDB; 1FE8; X-ray; 2.03 A; L/M/N=1-104.
DR PDB; 1FGN; X-ray; 2.50 A; L=1-107.
DR PDB; 1FJ1; X-ray; 2.68 A; A/C=1-106.
DR PDB; 1FL3; X-ray; 2.45 A; B/L=1-103.
DR PDB; 1FNS; X-ray; 2.00 A; L=1-107.
DR PDB; 1FRG; X-ray; 2.80 A; L=1-104.
DR PDB; 1FSK; X-ray; 2.90 A; B/E/H/K=1-107.
DR PDB; 1GPO; X-ray; 1.95 A; L/M=1-107.
DR PDB; 1HH6; X-ray; 2.60 A; A=1-107.
DR PDB; 1HH9; X-ray; 2.70 A; A=1-107.
DR PDB; 1HI6; X-ray; 2.55 A; A=1-107.
DR PDB; 1I8M; X-ray; 2.10 A; A/L=1-107.
DR PDB; 1IAI; X-ray; 2.90 A; M=1-107.
DR PDB; 1IGY; X-ray; 3.20 A; A/C=1-107.
DR PDB; 1JNL; X-ray; 3.00 A; L=1-104.
DR PDB; 1JNN; X-ray; 3.20 A; L=1-104.
DR PDB; 1JRH; X-ray; 2.80 A; L=1-107.
DR PDB; 1K4C; X-ray; 2.00 A; B=1-105.
DR PDB; 1K4D; X-ray; 2.30 A; B=1-105.
DR PDB; 1KB5; X-ray; 2.50 A; L=1-107.
DR PDB; 1KC5; X-ray; 2.50 A; L=1-107.
DR PDB; 1KCR; X-ray; 2.90 A; L=1-107.
DR PDB; 1KCS; X-ray; 2.50 A; L=1-107.
DR PDB; 1KCU; X-ray; 2.20 A; L=1-107.
DR PDB; 1KCV; X-ray; 1.80 A; L=1-107.
DR PDB; 1KEN; X-ray; 3.50 A; L/U=1-105.
DR PDB; 1KNO; X-ray; 3.20 A; A/C/E=1-107.
DR PDB; 1LO0; X-ray; 2.00 A; L/X=1-107.
DR PDB; 1MF2; X-ray; 2.60 A; L/M=1-104.
DR PDB; 1MH5; X-ray; 2.10 A; A/L=1-107.
DR PDB; 1MLB; X-ray; 2.10 A; A=1-107.
DR PDB; 1MLC; X-ray; 2.50 A; A/C=1-107.
DR PDB; 1N5Y; X-ray; 3.10 A; L=1-104.
DR PDB; 1N6Q; X-ray; 3.00 A; L=1-104.
DR PDB; 1NBY; X-ray; 1.80 A; A=1-107.
DR PDB; 1NBZ; X-ray; 1.85 A; A=1-107.
DR PDB; 1NDG; X-ray; 1.90 A; A=1-107.
DR PDB; 1NDM; X-ray; 2.10 A; A=1-107.
DR PDB; 1OAK; X-ray; 2.20 A; L=1-105.
DR PDB; 1OB1; X-ray; 2.90 A; A/D=1-107.
DR PDB; 1ORQ; X-ray; 3.20 A; A=1-107.
DR PDB; 1ORS; X-ray; 1.90 A; A=1-107.
DR PDB; 1OSP; X-ray; 1.95 A; L=1-107.
DR PDB; 1OTS; X-ray; 2.51 A; D/F=1-104.
DR PDB; 1OTT; X-ray; 3.00 A; D/F=1-104.
DR PDB; 1OTU; X-ray; 3.30 A; D/F=1-104.
DR PDB; 1P2C; X-ray; 2.00 A; A/D=1-105.
DR PDB; 1P7K; X-ray; 1.75 A; A/L=1-107.
DR PDB; 1PSK; X-ray; 2.80 A; L=1-107.
DR PDB; 1Q9O; X-ray; 1.79 A; A/C=1-107.
DR PDB; 1Q9W; X-ray; 1.75 A; A/C=1-107.
DR PDB; 1QGC; EM; 30.00 A; 4=1-107.
DR PDB; 1R0A; X-ray; 2.80 A; L=1-104.
DR PDB; 1R24; X-ray; 3.10 A; A/C=1-99.
DR PDB; 1R3I; X-ray; 2.40 A; L=1-105.
DR PDB; 1R3J; X-ray; 1.90 A; A=1-105.
DR PDB; 1R3K; X-ray; 2.80 A; A=1-105.
DR PDB; 1R3L; X-ray; 2.41 A; A=1-105.
DR PDB; 1RIH; X-ray; 2.50 A; L=1-107.
DR PDB; 1RUQ; X-ray; 1.86 A; L=1-105.
DR PDB; 1RUR; X-ray; 1.50 A; L=1-105.
DR PDB; 1S5H; X-ray; 2.20 A; A=1-105.
DR PDB; 1SEQ; X-ray; 1.78 A; L=1-107.
DR PDB; 1T03; X-ray; 3.10 A; L=1-104.
DR PDB; 1T4K; X-ray; 2.50 A; C=1-105.
DR PDB; 1UB5; X-ray; 2.00 A; B/L=1-102.
DR PDB; 1UB6; X-ray; 2.12 A; B/L=1-102.
DR PDB; 1UWX; X-ray; 2.20 A; K/L=1-106.
DR PDB; 1XF2; X-ray; 2.30 A; A/L=1-107.
DR PDB; 1XF3; X-ray; 2.30 A; A/L=1-107.
DR PDB; 1XF4; X-ray; 2.50 A; A/L=1-107.
DR PDB; 1XGP; X-ray; 2.10 A; A=1-107.
DR PDB; 1XGQ; X-ray; 2.10 A; A=1-107.
DR PDB; 1XGU; X-ray; 2.10 A; A=1-107.
DR PDB; 25C8; X-ray; 2.00 A; L=1-104.
DR PDB; 2A6D; X-ray; 2.90 A; L=1-107.
DR PDB; 2A6K; X-ray; 3.00 A; A/L=1-107.
DR PDB; 2ADF; X-ray; 1.90 A; L=1-103.
DR PDB; 2ADJ; X-ray; 2.90 A; A=1-107.
DR PDB; 2AJS; X-ray; 1.70 A; L=1-104.
DR PDB; 2AJU; X-ray; 1.50 A; L=1-104.
DR PDB; 2AJV; X-ray; 1.50 A; L=1-104.
DR PDB; 2AJX; X-ray; 1.85 A; L=1-104.
DR PDB; 2AJY; X-ray; 2.10 A; L=1-104.
DR PDB; 2AJZ; X-ray; 2.30 A; A/L=1-104.
DR PDB; 2AK1; X-ray; 1.85 A; L=1-104.
DR PDB; 2BOB; X-ray; 2.76 A; B=1-105.
DR PDB; 2BOC; X-ray; 3.01 A; B=1-105.
DR PDB; 2CK0; X-ray; 2.20 A; L=1-104.
DR PDB; 2F19; X-ray; 2.80 A; L=1-107.
DR PDB; 2FR4; X-ray; 1.95 A; A=1-107.
DR PDB; 2G5B; X-ray; 2.30 A; C/E/G=1-105.
DR PDB; 2H8P; X-ray; 2.25 A; B=1-105.
DR PDB; 2HG5; X-ray; 2.75 A; B=1-105.
DR PDB; 2HRP; X-ray; 2.20 A; L/M=1-107.
DR PDB; 2MPA; X-ray; 2.60 A; L=9-13.
DR PDB; 2NR6; X-ray; 2.81 A; C/E=1-104.
DR PDB; 2Q76; X-ray; 2.00 A; A/C=1-105.
DR PDB; 2R1W; X-ray; 1.70 A; A=1-107.
DR PDB; 2R1Y; X-ray; 1.60 A; A=1-107.
DR PDB; 2R23; X-ray; 1.65 A; A=1-107.
DR PDB; 2R2B; X-ray; 1.60 A; A=1-107.
DR PDB; 2UYL; X-ray; 2.50 A; A/M/V/X=1-107.
DR PDB; 2V17; X-ray; 1.65 A; L=1-107.
DR PDB; 2V7H; X-ray; 2.80 A; A/L=1-107.
DR PDB; 2VC2; X-ray; 3.10 A; L=1-107.
DR PDB; 2VDK; X-ray; 2.80 A; L=1-107.
DR PDB; 2VDL; X-ray; 2.75 A; L=1-107.
DR PDB; 2VDM; X-ray; 2.90 A; L=1-107.
DR PDB; 2VDN; X-ray; 2.90 A; L=1-107.
DR PDB; 2VDO; X-ray; 2.51 A; L=1-107.
DR PDB; 2VDP; X-ray; 2.80 A; L=1-107.
DR PDB; 2VDQ; X-ray; 2.59 A; L=1-107.
DR PDB; 2VDR; X-ray; 2.40 A; L=1-107.
DR PDB; 2VL5; X-ray; 2.10 A; B/D=1-107.
DR PDB; 2VQ1; X-ray; 2.50 A; A/E=1-105.
DR PDB; 2VWE; X-ray; 3.40 A; C/J=1-107.
DR PDB; 2W60; X-ray; 1.50 A; B=1-105.
DR PDB; 2W65; X-ray; 2.21 A; B/D=1-105.
DR PDB; 2W9D; X-ray; 1.57 A; L=1-106.
DR PDB; 2W9E; X-ray; 2.90 A; L=1-106.
DR PDB; 2Z91; X-ray; 2.60 A; B/D=1-107.
DR PDB; 2Z92; X-ray; 2.30 A; B=1-107.
DR PDB; 2Z93; X-ray; 2.40 A; B/D=1-107.
DR PDB; 2ZJS; X-ray; 3.20 A; L=1-107.
DR PDB; 35C8; X-ray; 2.00 A; L=1-104.
DR PDB; 3BAE; X-ray; 1.59 A; L=1-106.
DR PDB; 3BGF; X-ray; 3.00 A; C/L=1-105.
DR PDB; 3BKC; X-ray; 1.90 A; L=1-107.
DR PDB; 3BKJ; X-ray; 1.59 A; L=1-107.
DR PDB; 3BKM; X-ray; 1.60 A; L=1-107.
DR PDB; 3BPC; X-ray; 1.85 A; A=1-107.
DR PDB; 3BQU; X-ray; 3.00 A; C=1-104.
DR PDB; 3BSZ; X-ray; 3.38 A; L/M=1-104.
DR PDB; 3BT2; X-ray; 2.50 A; L=1-107.
DR PDB; 3BZ4; X-ray; 1.80 A; A/C/E/G=1-107.
DR PDB; 3C5S; X-ray; 2.00 A; A/C=1-107.
DR PDB; 3C6S; X-ray; 1.80 A; A/C/E/G=1-107.
DR PDB; 3CFB; X-ray; 1.60 A; A/L=1-107.
DR PDB; 3CFC; X-ray; 1.70 A; L=1-107.
DR PDB; 3CFD; X-ray; 2.50 A; A/L=1-107.
DR PDB; 3CFE; X-ray; 2.99 A; A/L=1-107.
DR PDB; 3CK0; X-ray; 3.00 A; L=1-104.
DR PDB; 3CLE; X-ray; 2.50 A; L=1-107.
DR PDB; 3CLF; X-ray; 2.00 A; L=1-107.
DR PDB; 3CMO; X-ray; 2.30 A; L/X=1-104.
DR PDB; 3CVH; X-ray; 2.90 A; L/R=1-103.
DR PDB; 3CVI; X-ray; 1.80 A; L=1-103.
DR PDB; 3D9A; X-ray; 1.20 A; L=1-106.
DR PDB; 3EJZ; X-ray; 2.90 A; D/F=1-104.
DR PDB; 3EOT; X-ray; 1.90 A; L=1-107.
DR PDB; 3F7V; X-ray; 3.20 A; B=1-105.
DR PDB; 3F7Y; X-ray; 3.40 A; B=1-105.
DR PDB; 3FB6; X-ray; 3.00 A; B=1-105.
DR PDB; 3HFM; X-ray; 3.00 A; L=1-107.
DR PDB; 4KK5; X-ray; 3.17 A; D/F=1-104.
DR PDB; 4KK8; X-ray; 2.86 A; D/F=1-104.
DR PDB; 4KVC; X-ray; 2.31 A; L=1-105.
DR PDB; 4QNP; X-ray; 2.80 A; F/L=1-106.
DR PDB; 4ZXB; X-ray; 3.30 A; B=1-107.
DR PDB; 6FAB; X-ray; 1.90 A; L=1-107.
DR PDBsum; 15C8; -.
DR PDBsum; 1A0Q; -.
DR PDBsum; 1A3L; -.
DR PDBsum; 1AHW; -.
DR PDBsum; 1AI1; -.
DR PDBsum; 1AIF; -.
DR PDBsum; 1C12; -.
DR PDBsum; 1CF8; -.
DR PDBsum; 1CFN; -.
DR PDBsum; 1CFQ; -.
DR PDBsum; 1CFS; -.
DR PDBsum; 1CFT; -.
DR PDBsum; 1CIC; -.
DR PDBsum; 1CK0; -.
DR PDBsum; 1CT8; -.
DR PDBsum; 1DQJ; -.
DR PDBsum; 1DQM; -.
DR PDBsum; 1DQQ; -.
DR PDBsum; 1E4W; -.
DR PDBsum; 1E4X; -.
DR PDBsum; 1EHL; -.
DR PDBsum; 1EMT; -.
DR PDBsum; 1F11; -.
DR PDBsum; 1FAI; -.
DR PDBsum; 1FBI; -.
DR PDBsum; 1FDL; -.
DR PDBsum; 1FE8; -.
DR PDBsum; 1FGN; -.
DR PDBsum; 1FJ1; -.
DR PDBsum; 1FL3; -.
DR PDBsum; 1FNS; -.
DR PDBsum; 1FRG; -.
DR PDBsum; 1FSK; -.
DR PDBsum; 1GPO; -.
DR PDBsum; 1HH6; -.
DR PDBsum; 1HH9; -.
DR PDBsum; 1HI6; -.
DR PDBsum; 1I8M; -.
DR PDBsum; 1IAI; -.
DR PDBsum; 1IGY; -.
DR PDBsum; 1JNL; -.
DR PDBsum; 1JNN; -.
DR PDBsum; 1JRH; -.
DR PDBsum; 1K4C; -.
DR PDBsum; 1K4D; -.
DR PDBsum; 1KB5; -.
DR PDBsum; 1KC5; -.
DR PDBsum; 1KCR; -.
DR PDBsum; 1KCS; -.
DR PDBsum; 1KCU; -.
DR PDBsum; 1KCV; -.
DR PDBsum; 1KEN; -.
DR PDBsum; 1KNO; -.
DR PDBsum; 1LO0; -.
DR PDBsum; 1MF2; -.
DR PDBsum; 1MH5; -.
DR PDBsum; 1MLB; -.
DR PDBsum; 1MLC; -.
DR PDBsum; 1N5Y; -.
DR PDBsum; 1N6Q; -.
DR PDBsum; 1NBY; -.
DR PDBsum; 1NBZ; -.
DR PDBsum; 1NDG; -.
DR PDBsum; 1NDM; -.
DR PDBsum; 1OAK; -.
DR PDBsum; 1OB1; -.
DR PDBsum; 1ORQ; -.
DR PDBsum; 1ORS; -.
DR PDBsum; 1OSP; -.
DR PDBsum; 1OTS; -.
DR PDBsum; 1OTT; -.
DR PDBsum; 1OTU; -.
DR PDBsum; 1P2C; -.
DR PDBsum; 1P7K; -.
DR PDBsum; 1PSK; -.
DR PDBsum; 1Q9O; -.
DR PDBsum; 1Q9W; -.
DR PDBsum; 1QGC; -.
DR PDBsum; 1R0A; -.
DR PDBsum; 1R24; -.
DR PDBsum; 1R3I; -.
DR PDBsum; 1R3J; -.
DR PDBsum; 1R3K; -.
DR PDBsum; 1R3L; -.
DR PDBsum; 1RIH; -.
DR PDBsum; 1RUQ; -.
DR PDBsum; 1RUR; -.
DR PDBsum; 1S5H; -.
DR PDBsum; 1SEQ; -.
DR PDBsum; 1T03; -.
DR PDBsum; 1T4K; -.
DR PDBsum; 1UB5; -.
DR PDBsum; 1UB6; -.
DR PDBsum; 1UWX; -.
DR PDBsum; 1XF2; -.
DR PDBsum; 1XF3; -.
DR PDBsum; 1XF4; -.
DR PDBsum; 1XGP; -.
DR PDBsum; 1XGQ; -.
DR PDBsum; 1XGU; -.
DR PDBsum; 25C8; -.
DR PDBsum; 2A6D; -.
DR PDBsum; 2A6K; -.
DR PDBsum; 2ADF; -.
DR PDBsum; 2ADJ; -.
DR PDBsum; 2AJS; -.
DR PDBsum; 2AJU; -.
DR PDBsum; 2AJV; -.
DR PDBsum; 2AJX; -.
DR PDBsum; 2AJY; -.
DR PDBsum; 2AJZ; -.
DR PDBsum; 2AK1; -.
DR PDBsum; 2BOB; -.
DR PDBsum; 2BOC; -.
DR PDBsum; 2CK0; -.
DR PDBsum; 2F19; -.
DR PDBsum; 2FR4; -.
DR PDBsum; 2G5B; -.
DR PDBsum; 2H8P; -.
DR PDBsum; 2HG5; -.
DR PDBsum; 2HRP; -.
DR PDBsum; 2MPA; -.
DR PDBsum; 2NR6; -.
DR PDBsum; 2Q76; -.
DR PDBsum; 2R1W; -.
DR PDBsum; 2R1Y; -.
DR PDBsum; 2R23; -.
DR PDBsum; 2R2B; -.
DR PDBsum; 2UYL; -.
DR PDBsum; 2V17; -.
DR PDBsum; 2V7H; -.
DR PDBsum; 2VC2; -.
DR PDBsum; 2VDK; -.
DR PDBsum; 2VDL; -.
DR PDBsum; 2VDM; -.
DR PDBsum; 2VDN; -.
DR PDBsum; 2VDO; -.
DR PDBsum; 2VDP; -.
DR PDBsum; 2VDQ; -.
DR PDBsum; 2VDR; -.
DR PDBsum; 2VL5; -.
DR PDBsum; 2VQ1; -.
DR PDBsum; 2VWE; -.
DR PDBsum; 2W60; -.
DR PDBsum; 2W65; -.
DR PDBsum; 2W9D; -.
DR PDBsum; 2W9E; -.
DR PDBsum; 2Z91; -.
DR PDBsum; 2Z92; -.
DR PDBsum; 2Z93; -.
DR PDBsum; 2ZJS; -.
DR PDBsum; 35C8; -.
DR PDBsum; 3BAE; -.
DR PDBsum; 3BGF; -.
DR PDBsum; 3BKC; -.
DR PDBsum; 3BKJ; -.
DR PDBsum; 3BKM; -.
DR PDBsum; 3BPC; -.
DR PDBsum; 3BQU; -.
DR PDBsum; 3BSZ; -.
DR PDBsum; 3BT2; -.
DR PDBsum; 3BZ4; -.
DR PDBsum; 3C5S; -.
DR PDBsum; 3C6S; -.
DR PDBsum; 3CFB; -.
DR PDBsum; 3CFC; -.
DR PDBsum; 3CFD; -.
DR PDBsum; 3CFE; -.
DR PDBsum; 3CK0; -.
DR PDBsum; 3CLE; -.
DR PDBsum; 3CLF; -.
DR PDBsum; 3CMO; -.
DR PDBsum; 3CVH; -.
DR PDBsum; 3CVI; -.
DR PDBsum; 3D9A; -.
DR PDBsum; 3EJZ; -.
DR PDBsum; 3EOT; -.
DR PDBsum; 3F7V; -.
DR PDBsum; 3F7Y; -.
DR PDBsum; 3FB6; -.
DR PDBsum; 3HFM; -.
DR PDBsum; 4KK5; -.
DR PDBsum; 4KK8; -.
DR PDBsum; 4KVC; -.
DR PDBsum; 4QNP; -.
DR PDBsum; 4ZXB; -.
DR PDBsum; 6FAB; -.
DR AlphaFoldDB; P01837; -.
DR SMR; P01837; -.
DR IntAct; P01837; 1.
DR MINT; P01837; -.
DR CPTAC; non-CPTAC-3509; -.
DR EPD; P01837; -.
DR jPOST; P01837; -.
DR PeptideAtlas; P01837; -.
DR PRIDE; P01837; -.
DR ProteomicsDB; 267295; -.
DR ABCD; P01837; 2 sequenced antibodies.
DR MGI; MGI:96495; Igkc.
DR InParanoid; P01837; -.
DR PhylomeDB; P01837; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR ChiTaRS; Igkc; mouse.
DR EvolutionaryTrace; P01837; -.
DR PRO; PR:P01837; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01837; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0071735; C:IgG immunoglobulin complex; ISO:MGI.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; ISO:MGI.
DR GO; GO:0030183; P:B cell differentiation; IMP:MGI.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond;
KW Immunoglobulin domain; Reference proteome.
FT CHAIN <1..107
FT /note="Immunoglobulin kappa constant"
FT /id="PRO_0000153597"
FT DOMAIN 6..103
FT /note="Ig-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 27..87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:5073237"
FT DISULFID 107
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:5073237"
FT NON_TER 1
FT STRAND 7..11
FT /evidence="ECO:0007829|PDB:1RUR"
FT HELIX 15..19
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 22..35
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 52..56
FT /evidence="ECO:0007829|PDB:1RUR"
FT TURN 61..63
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 66..75
FT /evidence="ECO:0007829|PDB:1RUR"
FT HELIX 76..79
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 84..90
FT /evidence="ECO:0007829|PDB:1RUR"
FT STRAND 91..96
FT /evidence="ECO:0007829|PDB:1UB6"
FT STRAND 98..103
FT /evidence="ECO:0007829|PDB:1RUR"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:1Q9O"
SQ SEQUENCE 107 AA; 11934 MW; A3B25CFA8D7C30CC CRC64;
RADAAPTVSI FPPSSEQLTS GGASVVCFLN NFYPKDINVK WKIDGSERQN GVLNSWTDQD
SKDSTYSMSS TLTLTKDEYE RHNSYTCEAT HKTSTSPIVK SFNRNEC
