ID   APHR_MESAU              Reviewed;         167 AA.
AC   Q9Z1I7;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Aphrodisin;
DE   Flags: Precursor;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=9867863; DOI=10.1074/jbc.274.1.444;
RA   Maegert H.-J., Cieslak A., Alkan O., Luscher B., Kauffels W.,
RA   Forssmann W.-G.;
RT   "The golden hamster aphrodisin gene: structure, expression in parotid
RT   glands of female animals, and comparison to a similar murine gene.";
RL   J. Biol. Chem. 274:444-450(1999).
CC   -!- FUNCTION: Acts as an aphrodisiac pheromone, reliably eliciting
CC       copulatory behavior from male hamster.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the vagina, uterus, and Bartholin's
CC       glands of female hamsters. Secreted in vaginal discharge.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AJ225170; CAA12414.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9Z1I7; -.
DR   SMR; Q9Z1I7; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002448; OBP-like.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01173; ODORANTBNDNG.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   CHAIN           17..167
FT                   /note="Aphrodisin"
FT                   /id="PRO_0000017879"
FT   MOD_RES         17
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P09465"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        54..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..165
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   167 AA;  18940 MW;  FD76EB58EF254C19 CRC64;
     MVKILVLALV FSLAHAQDFA ELQGKWYTIV IAADNLEKIE EGGPLRFYFR HIDCYKNCSE
     MEITFYVITN NQCSKTTVIG YLKGNGTYQT QFEGNNIFQP LYITSDKIFF TNKNMDRAGQ
     ETNMIVVAGK GNALTPEENE ILVQFAHEKK IPVENILNIL ATDTCPE