IGLL1_MOUSE
ID IGLL1_MOUSE Reviewed; 209 AA.
AC P20764; E9QMX0; Q5W1K3;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Immunoglobulin lambda-like polypeptide 1;
DE AltName: Full=CD179 antigen-like family member B;
DE AltName: Full=Ig lambda-5;
DE AltName: CD_antigen=CD179b;
DE Flags: Precursor;
GN Name=Igll1; Synonyms=Igl-5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=15950724; DOI=10.1016/j.molimm.2005.01.003;
RA Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M.,
RA Dillon N.;
RT "Mapping and functional analysis of regulatory sequences in the mouse
RT lambda5-VpreB1 domain.";
RL Mol. Immunol. 42:1283-1292(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, AND TISSUE SPECIFICITY.
RX PubMed=3024017; DOI=10.1038/324579a0;
RA Sakaguchi N., Melchers F.;
RT "Lambda 5, a new light-chain-related locus selectively expressed in pre-B
RT lymphocytes.";
RL Nature 324:579-582(1986).
RN [4]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH SYVN1.
RX PubMed=29907570; DOI=10.1074/jbc.ra117.001267;
RA Yang Y., Kong S., Zhang Y., Melo-Cardenas J., Gao B., Zhang Y., Zhang D.D.,
RA Zhang B., Song J., Thorp E., Zhang K., Zhang J., Fang D.;
RT "The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a
RT critical checkpoint in B cell development in mice.";
RL J. Biol. Chem. 293:12934-12944(2018).
CC -!- FUNCTION: Critical for B-cell development.
CC {ECO:0000250|UniProtKB:P15814}.
CC -!- SUBUNIT: Interacts with VPREB1 (By similarity). Interacts with
CC SYNV1/HRD1 (via N-terminus); this interaction leads to increased IGLL1
CC ubiquitination and degradation in pre-B cells, possibly through a
CC lysosomal, not proteasomal, pathway (PubMed:29907570). {ECO:0000250,
CC ECO:0000250|UniProtKB:P15814, ECO:0000269|PubMed:29907570}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:29907570}. Secreted {ECO:0000250}. Note=In pre-B
CC cells, localizes predominantly to the endoplasmic reticulum.
CC {ECO:0000269|PubMed:29907570}.
CC -!- TISSUE SPECIFICITY: Selectively expressed in pre-B lymphocytes.
CC {ECO:0000269|PubMed:3024017}.
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DR EMBL; AJ852426; CAH68524.1; -; Genomic_DNA.
DR EMBL; AC166832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M30387; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49775.1; -.
DR PIR; B26434; B26434.
DR RefSeq; NP_001177254.1; NM_001190325.1.
DR AlphaFoldDB; P20764; -.
DR SMR; P20764; -.
DR BioGRID; 200596; 3.
DR STRING; 10090.ENSMUSP00000097713; -.
DR PaxDb; P20764; -.
DR PRIDE; P20764; -.
DR ProteomicsDB; 269386; -.
DR Ensembl; ENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
DR GeneID; 16136; -.
DR KEGG; mmu:16136; -.
DR UCSC; uc007yje.1; mouse.
DR CTD; 3543; -.
DR MGI; MGI:96529; Igll1.
DR VEuPathDB; HostDB:ENSMUSG00000075370; -.
DR eggNOG; ENOG502SS4M; Eukaryota.
DR GeneTree; ENSGT00940000164874; -.
DR InParanoid; P20764; -.
DR OMA; PHSRYSC; -.
DR OrthoDB; 1568661at2759; -.
DR PhylomeDB; P20764; -.
DR TreeFam; TF335549; -.
DR BioGRID-ORCS; 16136; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Igll1; mouse.
DR PRO; PR:P20764; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P20764; protein.
DR Bgee; ENSMUSG00000075370; Expressed in bone marrow and 16 other tissues.
DR Genevisible; P20764; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0071735; C:IgG immunoglobulin complex; ISO:MGI.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endoplasmic reticulum; Immunoglobulin domain;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..209
FT /note="Immunoglobulin lambda-like polypeptide 1"
FT /id="PRO_0000153611"
FT DOMAIN 110..204
FT /note="Ig-like C1-type"
FT REGION 93..104
FT /note="J region (By similarity to lambda light-chain)"
FT REGION 105..209
FT /note="C region (By similarity to lambda light-chain)"
FT DISULFID 131..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 208
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 124..129
FT /note="ANKATL -> PTRPHV (in Ref. 1; CAH68524)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="T -> Q (in Ref. 3; M30387)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="Y -> T (in Ref. 3; M30387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 22772 MW; E0ADE721EAEB491E CRC64;
MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA SVGSNRPSLW
ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL TILGQPKSDP LVTLFLPSLK
NLQANKATLV CLVSEFYPGT LVVDWKVDGV PVTQGVETTQ PSKQTNNKYM VSSYLTLISD
QWMPHSRYSC RVTHEGNTVE KSVSPAECS
