ID   IGLL1_MUSSP             Reviewed;         105 AA.
AC   P20765;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Immunoglobulin lambda-like polypeptide 1;
DE   AltName: Full=CD179 antigen-like family member B;
DE   AltName: Full=Ig lambda-5;
DE   AltName: CD_antigen=CD179b;
DE   Flags: Fragment;
GN   Name=Igll1;
OS   Mus spretus (Western Mediterranean mouse) (Algerian mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10096;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3129289; DOI=10.1002/j.1460-2075.1988.tb02790.x;
RA   Mami F., Cazenave P.-A., Kindt T.J.;
RT   "Conservation of the immunoglobulin C lambda 5 gene in the Mus genus.";
RL   EMBO J. 7:117-122(1988).
CC   -!- FUNCTION: Critical for B-cell development.
CC       {ECO:0000250|UniProtKB:P15814}.
CC   -!- SUBUNIT: Associates non-covalently with VPREB1 (By similarity).
CC       Interacts with SYNV1/HRD1 (via N-terminus); this interaction leads to
CC       increased IGLL1 ubiquitination and degradation in pre-B cells, possibly
CC       through a lysosomal, not proteasomal, pathway (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:P15814,
CC       ECO:0000250|UniProtKB:P20764}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P20764}. Secreted
CC       {ECO:0000250|UniProtKB:P20764}. Note=In pre-B cells, localizes
CC       predominantly to the endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:P20764}.
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DR   EMBL; M35582; AAA39152.1; -; Genomic_DNA.
DR   PIR; S00259; S00259.
DR   AlphaFoldDB; P20765; -.
DR   SMR; P20765; -.
DR   MGI; MGI:96529; Igll1.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Endoplasmic reticulum; Immunoglobulin domain; Secreted.
FT   CHAIN           <1..105
FT                   /note="Immunoglobulin lambda-like polypeptide 1"
FT                   /id="PRO_0000153612"
FT   DOMAIN          6..100
FT                   /note="Ig-like C1-type"
FT   REGION          1..105
FT                   /note="C region (By similarity to lambda light-chain)"
FT   DISULFID        27..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        104
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   105 AA;  11674 MW;  AAB417DF68471A17 CRC64;
     QPKSDPLVTL FLPSLKNLQA NKVTLVCLVS EFYPGTLVVD WKVDGVPVTQ GVETTQPSKQ
     TNNKYMVSSY LTLISDQWMP HSRYSCRVTH EGNTVEKSVS PAECS