IGLO5_HUMAN
ID IGLO5_HUMAN Reviewed; 336 AA.
AC A6NGN9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 4.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=IgLON family member 5;
DE Flags: Precursor;
GN Name=IGLON5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-336.
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family.
CC {ECO:0000305}.
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DR EMBL; AC063977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR592222; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS46158.1; -.
DR RefSeq; NP_001094842.1; NM_001101372.1.
DR PDB; 6DLD; X-ray; 3.30 A; A/C=31-316.
DR PDB; 6DLE; X-ray; 3.99 A; A/B=31-316.
DR PDBsum; 6DLD; -.
DR PDBsum; 6DLE; -.
DR AlphaFoldDB; A6NGN9; -.
DR SMR; A6NGN9; -.
DR STRING; 9606.ENSP00000270642; -.
DR GlyGen; A6NGN9; 5 sites.
DR iPTMnet; A6NGN9; -.
DR PhosphoSitePlus; A6NGN9; -.
DR BioMuta; IGLON5; -.
DR EPD; A6NGN9; -.
DR jPOST; A6NGN9; -.
DR MassIVE; A6NGN9; -.
DR PaxDb; A6NGN9; -.
DR PeptideAtlas; A6NGN9; -.
DR PRIDE; A6NGN9; -.
DR ProteomicsDB; 1141; -.
DR Antibodypedia; 49473; 25 antibodies from 11 providers.
DR DNASU; 402665; -.
DR Ensembl; ENST00000270642.9; ENSP00000270642.8; ENSG00000142549.10.
DR GeneID; 402665; -.
DR KEGG; hsa:402665; -.
DR MANE-Select; ENST00000270642.9; ENSP00000270642.8; NM_001101372.3; NP_001094842.1.
DR UCSC; uc002pwc.3; human.
DR CTD; 402665; -.
DR DisGeNET; 402665; -.
DR GeneCards; IGLON5; -.
DR HGNC; HGNC:34550; IGLON5.
DR HPA; ENSG00000142549; Tissue enhanced (brain, retina).
DR MIM; 618861; gene.
DR neXtProt; NX_A6NGN9; -.
DR OpenTargets; ENSG00000142549; -.
DR PharmGKB; PA164720915; -.
DR VEuPathDB; HostDB:ENSG00000142549; -.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160467; -.
DR HOGENOM; CLU_027228_2_3_1; -.
DR InParanoid; A6NGN9; -.
DR OMA; QKHEERW; -.
DR OrthoDB; 583722at2759; -.
DR PhylomeDB; A6NGN9; -.
DR TreeFam; TF325565; -.
DR PathwayCommons; A6NGN9; -.
DR SignaLink; A6NGN9; -.
DR BioGRID-ORCS; 402665; 129 hits in 1025 CRISPR screens.
DR ChiTaRS; IGLON5; human.
DR GenomeRNAi; 402665; -.
DR Pharos; A6NGN9; Tdark.
DR PRO; PR:A6NGN9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NGN9; protein.
DR Bgee; ENSG00000142549; Expressed in ganglionic eminence and 124 other tissues.
DR Genevisible; A6NGN9; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..336
FT /note="IgLON family member 5"
FT /id="PRO_0000332301"
FT DOMAIN 33..122
FT /note="Ig-like C2-type 1"
FT DOMAIN 132..217
FT /note="Ig-like C2-type 2"
FT DOMAIN 218..307
FT /note="Ig-like C2-type 3"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 154..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 238..291
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT STRAND 38..45
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 50..55
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 62..67
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 70..74
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 94..101
FT /evidence="ECO:0007829|PDB:6DLD"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 108..115
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 120..138
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 149..160
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 163..171
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 177..184
FT /evidence="ECO:0007829|PDB:6DLD"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 191..198
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 208..224
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 234..244
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 247..252
FT /evidence="ECO:0007829|PDB:6DLD"
FT HELIX 262..264
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 265..269
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 271..278
FT /evidence="ECO:0007829|PDB:6DLD"
FT TURN 283..285
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 287..294
FT /evidence="ECO:0007829|PDB:6DLD"
FT STRAND 299..307
FT /evidence="ECO:0007829|PDB:6DLD"
SQ SEQUENCE 336 AA; 36795 MW; 9C1AD42E4BDC562B CRC64;
MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFNSPAD NYTVCEGDNA TLSCFIDEHV
TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT EVGLGDEGLY TCSFQTRHQP
YTTQVYLIVH VPARIVNISS PVTVNEGGNV NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL
EISDIQRGQA GEYECVTHNG VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA
MAVPPADFQW YKDDRLLSSG TAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
SASMRLLRPG SLENSAPRPP GLLALLSALG WLWWRM
