IGLO5_MOUSE
ID IGLO5_MOUSE Reviewed; 336 AA.
AC Q8HW98; A7E1X9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=IgLON family member 5;
DE Flags: Precursor;
GN Name=Iglon5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-336.
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-336.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family.
CC {ECO:0000305}.
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DR EMBL; AC154108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK039193; BAC30273.1; -; mRNA.
DR EMBL; BC116421; AAI16422.1; -; mRNA.
DR EMBL; BC116422; AAI16423.1; -; mRNA.
DR CCDS; CCDS52223.1; -.
DR RefSeq; NP_001157990.1; NM_001164518.1.
DR AlphaFoldDB; Q8HW98; -.
DR SMR; Q8HW98; -.
DR IntAct; Q8HW98; 1.
DR MINT; Q8HW98; -.
DR STRING; 10090.ENSMUSP00000103608; -.
DR GlyConnect; 2378; 3 N-Linked glycans (2 sites).
DR GlyGen; Q8HW98; 6 sites, 3 N-linked glycans (2 sites).
DR PhosphoSitePlus; Q8HW98; -.
DR MaxQB; Q8HW98; -.
DR PaxDb; Q8HW98; -.
DR PeptideAtlas; Q8HW98; -.
DR PRIDE; Q8HW98; -.
DR ProteomicsDB; 267296; -.
DR Antibodypedia; 49473; 25 antibodies from 11 providers.
DR Ensembl; ENSMUST00000107974; ENSMUSP00000103608; ENSMUSG00000013367.
DR GeneID; 210094; -.
DR KEGG; mmu:210094; -.
DR UCSC; uc009gmv.2; mouse.
DR CTD; 402665; -.
DR MGI; MGI:2686277; Iglon5.
DR VEuPathDB; HostDB:ENSMUSG00000013367; -.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160467; -.
DR HOGENOM; CLU_027228_2_3_1; -.
DR InParanoid; Q8HW98; -.
DR OMA; QKHEERW; -.
DR OrthoDB; 583722at2759; -.
DR PhylomeDB; Q8HW98; -.
DR TreeFam; TF325565; -.
DR BioGRID-ORCS; 210094; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8HW98; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8HW98; protein.
DR Bgee; ENSMUSG00000013367; Expressed in embryonic brain and 84 other tissues.
DR ExpressionAtlas; Q8HW98; baseline and differential.
DR Genevisible; Q8HW98; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..336
FT /note="IgLON family member 5"
FT /id="PRO_0000332302"
FT DOMAIN 33..122
FT /note="Ig-like C2-type 1"
FT DOMAIN 132..213
FT /note="Ig-like C2-type 2"
FT DOMAIN 218..307
FT /note="Ig-like C2-type 3"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 154..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 238..291
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 12
FT /note="L -> V (in Ref. 2; BAC30273)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="N -> D (in Ref. 2; BAC30273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 36767 MW; FF41D4EFE02ED8A9 CRC64;
MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFSSPAD NYTVCEGDNA TLSCFIDEHV
TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT QVGLGDEGLY TCSFQTRHQP
YTTQVYLIVH VPARIVNISS PVAVNEGGNV NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL
EISDIQRGQA GEYECVTHNG VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA
MAVPPADFQW YKDDRLLSSG SAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
SASMRLLRPG SLENSAPRPP GPLTLLSALS WLWWRM
