IGS10_MOUSE
ID IGS10_MOUSE Reviewed; 2594 AA.
AC Q3V1M1; Q3UPM4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Immunoglobulin superfamily member 10;
DE Short=IgSF10;
DE Flags: Precursor;
GN Name=Igsf10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1196 AND 1297-2594.
RC STRAIN=C57BL/6J; TISSUE=Head, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=27137492; DOI=10.15252/emmm.201606250;
RA Howard S.R., Guasti L., Ruiz-Babot G., Mancini A., David A., Storr H.L.,
RA Metherell L.A., Sternberg M.J., Cabrera C.P., Warren H.R., Barnes M.R.,
RA Quinton R., de Roux N., Young J., Guiochon-Mantel A., Wehkalampi K.,
RA Andre V., Gothilf Y., Cariboni A., Dunkel L.;
RT "IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal
RT migration resulting in delayed puberty.";
RL EMBO Mol. Med. 8:626-642(2016).
CC -!- FUNCTION: Involved in the control of early migration of neurons
CC expressing gonadotropin-releasing hormone (GNRH neurons)
CC (PubMed:27137492). May be involved in the maintenance of
CC osteochondroprogenitor cells pool (By similarity).
CC {ECO:0000250|UniProtKB:Q6WRH9, ECO:0000269|PubMed:27137492}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6WRI0}.
CC -!- TISSUE SPECIFICITY: In the embryo, expressed in the nasal mesenchyme.
CC {ECO:0000269|PubMed:27137492}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK081990; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC122038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK143421; BAE25371.1; -; mRNA.
DR EMBL; AC135238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK132367; BAE21129.1; -; mRNA.
DR EMBL; AK081990; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS50915.1; -.
DR RefSeq; NP_001156356.1; NM_001162884.1.
DR RefSeq; XP_006501528.1; XM_006501465.3.
DR RefSeq; XP_006501529.1; XM_006501466.3.
DR RefSeq; XP_006501530.1; XM_006501467.3.
DR RefSeq; XP_011238419.1; XM_011240117.2.
DR AlphaFoldDB; Q3V1M1; -.
DR SMR; Q3V1M1; -.
DR BioGRID; 232370; 1.
DR STRING; 10090.ENSMUSP00000037246; -.
DR GlyGen; Q3V1M1; 9 sites.
DR iPTMnet; Q3V1M1; -.
DR PhosphoSitePlus; Q3V1M1; -.
DR MaxQB; Q3V1M1; -.
DR PaxDb; Q3V1M1; -.
DR PeptideAtlas; Q3V1M1; -.
DR PRIDE; Q3V1M1; -.
DR ProteomicsDB; 267204; -.
DR Antibodypedia; 2541; 66 antibodies from 14 providers.
DR Ensembl; ENSMUST00000039419; ENSMUSP00000037246; ENSMUSG00000036334.
DR Ensembl; ENSMUST00000193455; ENSMUSP00000141971; ENSMUSG00000036334.
DR Ensembl; ENSMUST00000194546; ENSMUSP00000141391; ENSMUSG00000036334.
DR GeneID; 242050; -.
DR KEGG; mmu:242050; -.
DR UCSC; uc008piu.2; mouse.
DR CTD; 285313; -.
DR MGI; MGI:1923481; Igsf10.
DR VEuPathDB; HostDB:ENSMUSG00000036334; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158290; -.
DR HOGENOM; CLU_000580_0_0_1; -.
DR InParanoid; Q3V1M1; -.
DR OMA; IWGRGRI; -.
DR OrthoDB; 8971at2759; -.
DR PhylomeDB; Q3V1M1; -.
DR TreeFam; TF326318; -.
DR BioGRID-ORCS; 242050; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Igsf10; mouse.
DR PRO; PR:Q3V1M1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3V1M1; protein.
DR Bgee; ENSMUSG00000036334; Expressed in skin epidermis and 108 other tissues.
DR ExpressionAtlas; Q3V1M1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0001503; P:ossification; ISO:MGI.
DR GO; GO:2001222; P:regulation of neuron migration; IMP:UniProtKB.
DR GO; GO:0042246; P:tissue regeneration; ISO:MGI.
DR Gene3D; 2.60.40.10; -; 12.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 9.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 12.
DR SMART; SM00408; IGc2; 12.
DR SMART; SM00406; IGv; 6.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 12.
DR PROSITE; PS50835; IG_LIKE; 12.
DR PROSITE; PS51450; LRR; 7.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..2594
FT /note="Immunoglobulin superfamily member 10"
FT /id="PRO_0000286818"
FT DOMAIN 29..56
FT /note="LRRNT"
FT REPEAT 58..79
FT /note="LRR 1"
FT REPEAT 82..103
FT /note="LRR 2"
FT REPEAT 106..127
FT /note="LRR 3"
FT REPEAT 130..151
FT /note="LRR 4"
FT REPEAT 154..175
FT /note="LRR 5"
FT REPEAT 186..207
FT /note="LRR 6"
FT DOMAIN 219..281
FT /note="LRRCT"
FT DOMAIN 461..567
FT /note="Ig-like C2-type 1"
FT DOMAIN 571..661
FT /note="Ig-like C2-type 2"
FT DOMAIN 1619..1710
FT /note="Ig-like C2-type 3"
FT REPEAT 1658..1681
FT /note="LRR 11"
FT DOMAIN 1715..1807
FT /note="Ig-like C2-type 4"
FT DOMAIN 1812..1901
FT /note="Ig-like C2-type 5"
FT DOMAIN 1912..2005
FT /note="Ig-like C2-type 6"
FT DOMAIN 2008..2106
FT /note="Ig-like C2-type 7"
FT DOMAIN 2112..2200
FT /note="Ig-like C2-type 8"
FT DOMAIN 2205..2302
FT /note="Ig-like C2-type 9"
FT DOMAIN 2308..2398
FT /note="Ig-like C2-type 10"
FT DOMAIN 2403..2493
FT /note="Ig-like C2-type 11"
FT DOMAIN 2499..2592
FT /note="Ig-like C2-type 12"
FT REGION 670..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2574
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q6WRH9"
FT CARBOHYD 439
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 627
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1044
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1676
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1780
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1870
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1933
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2072
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 497..551
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 595..645
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1641..1694
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1738..1791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1835..1888
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1934..1987
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2031..2090
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2134..2184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2232..2284
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2330..2382
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2425..2477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2521..2576
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 150
FT /note="Y -> C (in Ref. 2; BAE25371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2594 AA; 285598 MW; A37D90B7FD255DB6 CRC64;
MQKRGREVSC LLISLTAICL VVTPGSRVCP RRCACYVPTE VHCTFRYLTS IPDGIPANVE
RVNLGYNSLT RLTENDFSGL SRLELLMLHS NGIHRVSDKT FSGLQSLQVL KMSYNKVQII
EKDTLYGLRS LTRLHLDHNN IEFINPEAFY GLTLLRLVHL EGNRLTKLHP DTFVSLSYLQ
IFKTSFIKYL YLSDNFLTSL PKEMVSSMPN LESLYLHGNP WTCDCHLKWL SEWMQGNPDI
IKCKKERIPS SPQQCPLCMN PRISKGRSIA MVPSGSFLCT KPTIDPSLKS KSLGIQEDNG
SASVSPQDFI EPFGSLSLNM TDLSGNKANV ICSIQKPSRT LPIAFTEEND YIMLNMSFST
NLVCSVNYNH IQPVWQLLAL YSDSPLILER KPQHTETPLL SPKYQQVALR PEDTFTNIEA
DFKADPFWFQ QEKISLQLNR TATTLSTLQI QFSTDAQITL PKAEMRPVKR KWTMILMMNN
TRLEHTVLVG GTIALDCPGK GDPSPHLEWV LADGSKVRAP YVSEDGRILI DKKGKLELQM
ADTFDAGLYH CISTNDADAD ILTYRITVVE PYVENKHENG ALHTVIMGEI LDLPCLSTGI
PDASISWILP RNTVFSQSSR DMQILNNGTL RILQATPKDQ GHYRCVAANP SGADFSSFQV
SVQMKGQRTI EHDRDIDGSG LEEPKPSVLL KQPPSLKLPA SSLTGTEAGK QVSGIHKKNK
HRDLTHRRRG DSTLRRFREH RRQLPLSARR IDPQHWAALL EKAKKNSVLR KQENTTVKPT
PLAIPLVELA GEEKDASGLT PPDEEFTVLK TKAFGVPERS PTADSRPVNH GFVTSSASGT
EVSSTVNPQT LLPTHLPDFK LFNVVDSAAV SKSMNRPVTS KIEDTTHQNP IIIFPSVAEI
QDSAQVGRTS SQSAHPATGG AMATYGYTTM LSSFTNKANT VLQSANPTES YGPQIPLTEV
SRVSSNNSLA HTTKDPGFSK RPSDSHTTAP SLFQTPRNNS TGNVGRERTI WSRGRAISPY
RTPVLRRHRH RIVRPALKGP ANRNISQVSA TEPPGMCRTC SSTERLTMAT AALSVTGSSH
TTLPKANNVG IISEESTTVV KKPSLLLKNK QDVDIETITT TINYFRSEST HMTPTEASMI
SAPTSISLGK TPIDTSGHLS MPRTIQAGTD LVVTPPLSSP LSQPSIPTKA TSTKLSRRKI
PWHPIFANNH NKEGMLKNLH QFGLQKNTAT KPPEKAPLLP TDHGSSSPST TLLASLTPAQ
SATMAATRRN GTEVQGARSL SAGKEQPFIN SFLVLPSTTR KRSSTLSFLS VETPTVTTPP
VIASAIISET QEVRSKKAKD QTKGSLKNRK GPTITPRQIS GYSTYSVPTT TDTPLAFSHS
PGKVTGRTVS TAAPHSAASL LGITELPQKC THTSGNITAS ETTLLSKSQE STAMKRASAT
PPLLSSGAPR MPTPSPPPFT KVVVTDSEVP AVFKMMSNRM VTIYESSRHD IDLQQPSAEA
SPNPEILTGS TDFPLSSLLT STPMPAPRVD KPQDSQWKPS PWPENKFQLR SYSETIEKGK
RPEISLSPHL SFPEASTHAL HWNAQRHAEK SVFDKKPAQN PTSKHLPYDS LPKTILKKPR
IIGGKAASFT VPTNSDVLLP CEAVGDPKPT IHWTRVSSGR EISRGIQKTR FHVLPNGTLS
IQRVSIQDRG QYLCAASNPL GVDHLHVTLS VVSYPARILE SHVKEITAHS GSTVKLKCRV
EGMPRPTISW ILANQTVVSE TPEGSRKVWV TPDGTLIIHN LSLYDRGFYK CVANNPSGQD
SLLVKIQVIT APPVIIEQKR QAIVGVLGES LKLPCTAKGT PQPSVHWVLY DGTELKPLQL
THSRFFLYPN GTLYIRNIVS SVRGTYECIA TSSSGSERRV VILRVEEQET VPRIETASQK
WTEVNLGEKL LLNCSATGDP KPTIIWKLPS KVVIDQWHRM GSRIHVYPNG SLVIGSVTEK
DGGDYLCVAR NKMGDDLVLM HVRLRLTPAK IEHKQHFKKQ VLHGKDFQVD CKASGSPVPE
VSWSLPDGTV VNNVAQADDS GYRTKRYTLF HNGTLYFNKV GMAEEGDYIC SAQNTLGKDE
MKVHLTVLTA IPRIRQNYRS NVRIKAGDTA VLDCEVTGEP KPNVFWLLPS NNVISFSNDR
FIFHANGTLS INKVKPLDSG KYVCVAQNPS GDDTKTYKLD IVSRPPLING LYANKTVIKA
TAIQHSKKHL DCRADGVPPP QITWIMPDNI FLTAPYYGGR ITVHQNGTLE IRNIRLSDSA
DFTCVVRSEG GESVLVVQLK VLEMLRRPTF RNPFNEKVVA QVGKPVAMNC SVDGNPTPEI
IWILPDGTQF ANGPQNSPYL MASNGSLIVY KATRNKSGKY RCTARNKVGY IEKLILLEIG
QKPVILTYEP GMIKSAGGES LSLHCVSDGI PKPNVKWTTP GGLVIDRPQV GGKYILHENG
TLVIKETTAH DRGNYICKAQ NSVGQAVISV PVTIVAYPPR IINYLPRSML RRTGEAMQLH
CVALGVPKPQ ITWETPGYSL LSTATERRPH RSEMLPLQGT LVIQNLRASD SGVYKCRAQN
VLGADYATTY IQVL
