ID   IGS23_HUMAN             Reviewed;         192 AA.
AC   A1L1A6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Immunoglobulin superfamily member 23;
GN   Name=IGSF23;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC138472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC127928; AAI27929.1; -; mRNA.
DR   EMBL; BC127929; AAI27930.1; -; mRNA.
DR   CCDS; CCDS54277.1; -.
DR   RefSeq; NP_001192209.1; NM_001205280.1.
DR   AlphaFoldDB; A1L1A6; -.
DR   STRING; 9606.ENSP00000385592; -.
DR   GlyGen; A1L1A6; 1 site.
DR   BioMuta; IGSF23; -.
DR   jPOST; A1L1A6; -.
DR   PaxDb; A1L1A6; -.
DR   PeptideAtlas; A1L1A6; -.
DR   PRIDE; A1L1A6; -.
DR   Antibodypedia; 70970; 8 antibodies from 4 providers.
DR   DNASU; 147710; -.
DR   Ensembl; ENST00000402988.6; ENSP00000385592.1; ENSG00000216588.9.
DR   GeneID; 147710; -.
DR   KEGG; hsa:147710; -.
DR   MANE-Select; ENST00000402988.6; ENSP00000385592.1; NM_001205280.2; NP_001192209.1.
DR   UCSC; uc021uvj.1; human.
DR   CTD; 147710; -.
DR   DisGeNET; 147710; -.
DR   GeneCards; IGSF23; -.
DR   HGNC; HGNC:40040; IGSF23.
DR   HPA; ENSG00000216588; Group enriched (intestine, liver).
DR   neXtProt; NX_A1L1A6; -.
DR   OpenTargets; ENSG00000216588; -.
DR   VEuPathDB; HostDB:ENSG00000216588; -.
DR   eggNOG; ENOG502RU2R; Eukaryota.
DR   GeneTree; ENSGT00390000015308; -.
DR   InParanoid; A1L1A6; -.
DR   OMA; MRAKPQS; -.
DR   OrthoDB; 1362674at2759; -.
DR   TreeFam; TF339455; -.
DR   PathwayCommons; A1L1A6; -.
DR   SignaLink; A1L1A6; -.
DR   BioGRID-ORCS; 147710; 8 hits in 1065 CRISPR screens.
DR   ChiTaRS; IGSF23; human.
DR   GenomeRNAi; 147710; -.
DR   Pharos; A1L1A6; Tdark.
DR   PRO; PR:A1L1A6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A1L1A6; protein.
DR   Bgee; ENSG00000216588; Expressed in right lobe of liver and 78 other tissues.
DR   ExpressionAtlas; A1L1A6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..192
FT                   /note="Immunoglobulin superfamily member 23"
FT                   /id="PRO_0000410772"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..128
FT                   /note="Ig-like"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   192 AA;  20591 MW;  0B965768293F6B37 CRC64;
     MRAKPQSPLP RNPVPAWSPP TTTTDPMLEK DAAGGDFPAN LVLQLMPLKT FPAAIRGVIQ
     SELNYSVILQ WVVTMDPEPV LSWTFSGVPC GMGEKLFIRR LSCEQLGTYM CIATNSKKQL
     VSEPVTISLP KPIMQPTEAE PMEPDPTLSL SGGSAIGLLA AGILGAGALI AGMCFIIIQS
     LRTDRQRIGI CS