ID   IGSF3_XENTR             Reviewed;        1161 AA.
AC   A0JPB1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Immunoglobulin superfamily member 3;
DE            Short=IgSF3;
DE   Flags: Precursor;
GN   Name=igsf3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC127336; AAI27337.1; -; mRNA.
DR   RefSeq; NP_001090681.1; NM_001097212.1.
DR   AlphaFoldDB; A0JPB1; -.
DR   PRIDE; A0JPB1; -.
DR   DNASU; 100036654; -.
DR   GeneID; 100036654; -.
DR   KEGG; xtr:100036654; -.
DR   CTD; 3321; -.
DR   Xenbase; XB-GENE-18006038; igsf3.
DR   InParanoid; A0JPB1; -.
DR   OrthoDB; 180654at2759; -.
DR   Reactome; R-XTR-202433; Generation of second messenger molecules.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 8.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 4.
DR   SMART; SM00409; IG; 8.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00406; IGv; 7.
DR   SUPFAM; SSF48726; SSF48726; 8.
DR   PROSITE; PS50835; IG_LIKE; 7.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..1161
FT                   /note="Immunoglobulin superfamily member 3"
FT                   /id="PRO_0000320137"
FT   TOPO_DOM        17..1091
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1092..1112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1113..1161
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          18..135
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          140..258
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          272..382
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          402..523
FT                   /note="Ig-like C2-type 4"
FT   DOMAIN          541..651
FT                   /note="Ig-like C2-type 5"
FT   DOMAIN          674..796
FT                   /note="Ig-like C2-type 6"
FT   DOMAIN          806..930
FT                   /note="Ig-like C2-type 7"
FT   DOMAIN          947..1063
FT                   /note="Ig-like C2-type 8"
FT   MOTIF           246..248
FT                   /note="EWI motif"
FT   DISULFID        39..117
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        164..242
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        298..372
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        428..507
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        562..641
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        697..775
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        831..914
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        970..1047
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   1161 AA;  128475 MW;  997BCBB9C72875B0 CRC64;
     MGTAALLILL AGVSWAQREV AIQPGPLYRA EGSQISIWCN VRGYQGPSEQ NFLWSIYLPT
     APEKEIQIVG TNDPSFSYAI YSQRVRSGGI YVERVSGDRA LLHIRQLQDQ DTGEYECHTP
     NTDPSYHGSY SAKVNLQVIP DTLTVSSPAQ TIQKVEGGSL QVTCEVSQNS SRHTHLSVSW
     LRLSEGEATE IISVTQNFSV RPGPSYAQKH SVGDVRLDKV GDSTFRLTLY NLHPSDQGDI
     YCEGTEWIQD PDGTWFPLTQ KRSEGTSVTV LPTDKEFNVR LETERRTYNG GDTATLRCII
     EAQNPGDRLF AVSWAFNSSL IASQSPGGVP SLTGEYARRE DGGELRVGKD SDSVFSLKIF
     RLRPEDSGKY NCRVTERERG PSGELIDRES KRPKNIPISV LPLRTSLTVT VTANSSSVLE
     GVRLSLSCSV ASLAGPQSRV SASWHLQDKQ GRQRDVVRQD RDGVTWAGEQ YRERLGTGGL
     RLLRSGSDTF SLELEGSQRT DAGSYECRVA EWVPAPDGEW QLLGERSAQA NVDILALETG
     FAVTAITRTP GVTYFDSFDL QCILKPHYPP WVGVSVTWRF QPAGGGDTHD LVTFSRSGGV
     QWGERAGSFR GRSIVEKGDS THTVRLSVSR ASDSEAGKYQ CVAELWRRET SGMWARLAER
     ASNLLEIRVQ RPVPRLQVTK VTRTLSVVEG SPVTLSCSIR SQSGPDSRFA VLWLVQQPSG
     AEGKLIGRSD AGTEFGTYPE GALLKGRLQL GVTAPGQYAL TLQGARTDDS GSYYCQVEEW
     AMDPNQAWYR LAEETSGLTE IRVRPPDANL QLDQLPRNVS ALEGQSVTVT CHVLNRTLPD
     SRLSLEWLCW RAGHMERRGL ARLTVDGVLG SVEEEPGDVA PGLPSRVQVS QPSLGLYALT
     LRGTEVRDSG TYSCLVQEWL RDPRGQWYRR TEERSGATYV SVRQPDPQLQ LDPSLLNVSV
     MEGGHFDLDC MVSSRSRPDS QLAISWSLQG TSRGAEPETL LNVDRSGVWA PLAPRWEGRL
     QQLQLSPTLF RLHVPRVGPG DSGNYTCLVQ EWLLGPRGDW YLLAQDEAVI GWIRVQRKES
     NLQSTICAND ALFYLVFFYP FPIFGILIIT ILLVRFRHRP TGKPGEGKNG VPLLWIKEPH
     LNYSPTCLEP PVLSIHPGTI D