ID   IGSF6_MOUSE             Reviewed;         237 AA.
AC   P0C6B7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Immunoglobulin superfamily member 6;
DE            Short=IgSF6;
DE   Flags: Precursor;
GN   Name=Igsf6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=11132146; DOI=10.1007/s002510000259;
RA   Bates E.E.M., Kissenpfennig A., Peronne C., Mattei M.-G., Fossiez F.,
RA   Malissen B., Lebecque S.;
RT   "The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel
RT   disease 1 locus and are embedded in an intron of a gene of unknown
RT   function.";
RL   Immunogenetics 52:112-120(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous with higher expression in immune tissue.
CC       {ECO:0000269|PubMed:11132146}.
CC   -!- MISCELLANEOUS: This gene is coded entirely within the intron of Mettl9
CC       which is transcribed in the opposite strand of the DNA.
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DR   EMBL; AJ278574; CAC20696.1; -; Genomic_DNA.
DR   EMBL; AJ278575; CAC20697.1; -; mRNA.
DR   CCDS; CCDS21801.1; -.
DR   RefSeq; NP_109616.1; NM_030691.1.
DR   AlphaFoldDB; P0C6B7; -.
DR   SMR; P0C6B7; -.
DR   STRING; 10090.ENSMUSP00000039059; -.
DR   MaxQB; P0C6B7; -.
DR   PaxDb; P0C6B7; -.
DR   PeptideAtlas; P0C6B7; -.
DR   PRIDE; P0C6B7; -.
DR   ProteomicsDB; 269545; -.
DR   Antibodypedia; 25724; 200 antibodies from 23 providers.
DR   DNASU; 80719; -.
DR   Ensembl; ENSMUST00000047194; ENSMUSP00000039059; ENSMUSG00000035004.
DR   GeneID; 80719; -.
DR   KEGG; mmu:80719; -.
DR   UCSC; uc009jnm.1; mouse.
DR   CTD; 10261; -.
DR   MGI; MGI:1891393; Igsf6.
DR   VEuPathDB; HostDB:ENSMUSG00000035004; -.
DR   eggNOG; ENOG502S4JY; Eukaryota.
DR   GeneTree; ENSGT00390000014131; -.
DR   HOGENOM; CLU_1160783_0_0_1; -.
DR   InParanoid; P0C6B7; -.
DR   OMA; TSLWFRY; -.
DR   OrthoDB; 1230760at2759; -.
DR   PhylomeDB; P0C6B7; -.
DR   TreeFam; TF335767; -.
DR   BioGRID-ORCS; 80719; 2 hits in 71 CRISPR screens.
DR   PRO; PR:P0C6B7; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P0C6B7; protein.
DR   Bgee; ENSMUSG00000035004; Expressed in granulocyte and 53 other tissues.
DR   Genevisible; P0C6B7; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR039089; IGSF6.
DR   PANTHER; PTHR15297; PTHR15297; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..237
FT                   /note="Immunoglobulin superfamily member 6"
FT                   /id="PRO_0000320138"
FT   TOPO_DOM        28..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..134
FT                   /note="Ig-like C2-type"
FT   REGION          215..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        51..118
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   237 AA;  26354 MW;  838097E701C73FC0 CRC64;
     MGPVSARRSR LRPEISLILF QVGMVGACTV YVLQPGYLEV DYGSDAVTME CNFSTVGCPP
     VPPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDPDQ VFLTVNRLSP NDSAIYICGI
     AFPNELSPSA KHVGKGTTLV VRERLFSKEV RSFLIVLLAL LSVYITGVCV TFIVLFKSKS
     NGPRSRETKG SKKKSARRIF QEIAQELYHK RYVETSHLPE QEGTDENRKA LPNPGRA