IGSF6_RAT
ID IGSF6_RAT Reviewed; 238 AA.
AC Q9Z0K5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Immunoglobulin superfamily member 6;
DE Short=IgSF6;
DE AltName: Full=Protein DORA;
DE Flags: Precursor;
GN Name=Igsf6; Synonyms=Dora;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9809579; DOI=10.1016/s0161-5890(98)00045-5;
RA Bates E.E.M., Dieu M.-C., Ravel O., Zurawski S.M., Patel S., Bridon J.-M.,
RA Ait-Yahia S., Vega F. Jr., Banchereau J., Lebecque S.;
RT "CD40L activation of dendritic cells down-regulates DORA, a novel member of
RT the immunoglobulin superfamily.";
RL Mol. Immunol. 35:513-524(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: This gene is coded entirely within the intron of Mettl9
CC which is transcribed in the opposite strand of the DNA.
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DR EMBL; AJ223184; CAA11156.1; -; mRNA.
DR RefSeq; NP_598226.1; NM_133542.2.
DR AlphaFoldDB; Q9Z0K5; -.
DR SMR; Q9Z0K5; -.
DR STRING; 10116.ENSRNOP00000023262; -.
DR PaxDb; Q9Z0K5; -.
DR GeneID; 171064; -.
DR KEGG; rno:171064; -.
DR UCSC; RGD:620663; rat.
DR CTD; 10261; -.
DR RGD; 620663; Igsf6.
DR eggNOG; ENOG502S4JY; Eukaryota.
DR InParanoid; Q9Z0K5; -.
DR OrthoDB; 1230760at2759; -.
DR PhylomeDB; Q9Z0K5; -.
DR PRO; PR:Q9Z0K5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR039089; IGSF6.
DR PANTHER; PTHR15297; PTHR15297; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..238
FT /note="Immunoglobulin superfamily member 6"
FT /id="PRO_5000065015"
FT TOPO_DOM 28..153
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..134
FT /note="Ig-like C2-type"
FT REGION 215..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 51..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 238 AA; 26433 MW; 02C661D53755DECC CRC64;
MGPVSTSRRG LRLGISLILL QVGVVGACTV SVLQPGYLEV DYTSQTVTME CTFSTTGCPA
VQPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDQNR VSLTVNRLSP NDSAIYICGI
AFPNEPVPTA KQTGDGTTLV VRERLFSREV HSLLIVLLAL LAVYVTGVCV IFIVLFRSKS
NTPRSRETKE DSKKKSARRI FQEIAQELYH KRYVETSHQP EQDGNYENRK ALPSPGRP