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IGSF6_RAT
ID   IGSF6_RAT               Reviewed;         238 AA.
AC   Q9Z0K5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Immunoglobulin superfamily member 6;
DE            Short=IgSF6;
DE   AltName: Full=Protein DORA;
DE   Flags: Precursor;
GN   Name=Igsf6; Synonyms=Dora;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9809579; DOI=10.1016/s0161-5890(98)00045-5;
RA   Bates E.E.M., Dieu M.-C., Ravel O., Zurawski S.M., Patel S., Bridon J.-M.,
RA   Ait-Yahia S., Vega F. Jr., Banchereau J., Lebecque S.;
RT   "CD40L activation of dendritic cells down-regulates DORA, a novel member of
RT   the immunoglobulin superfamily.";
RL   Mol. Immunol. 35:513-524(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: This gene is coded entirely within the intron of Mettl9
CC       which is transcribed in the opposite strand of the DNA.
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DR   EMBL; AJ223184; CAA11156.1; -; mRNA.
DR   RefSeq; NP_598226.1; NM_133542.2.
DR   AlphaFoldDB; Q9Z0K5; -.
DR   SMR; Q9Z0K5; -.
DR   STRING; 10116.ENSRNOP00000023262; -.
DR   PaxDb; Q9Z0K5; -.
DR   GeneID; 171064; -.
DR   KEGG; rno:171064; -.
DR   UCSC; RGD:620663; rat.
DR   CTD; 10261; -.
DR   RGD; 620663; Igsf6.
DR   eggNOG; ENOG502S4JY; Eukaryota.
DR   InParanoid; Q9Z0K5; -.
DR   OrthoDB; 1230760at2759; -.
DR   PhylomeDB; Q9Z0K5; -.
DR   PRO; PR:Q9Z0K5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR039089; IGSF6.
DR   PANTHER; PTHR15297; PTHR15297; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..238
FT                   /note="Immunoglobulin superfamily member 6"
FT                   /id="PRO_5000065015"
FT   TOPO_DOM        28..153
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..134
FT                   /note="Ig-like C2-type"
FT   REGION          215..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        51..118
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   238 AA;  26433 MW;  02C661D53755DECC CRC64;
     MGPVSTSRRG LRLGISLILL QVGVVGACTV SVLQPGYLEV DYTSQTVTME CTFSTTGCPA
     VQPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDQNR VSLTVNRLSP NDSAIYICGI
     AFPNEPVPTA KQTGDGTTLV VRERLFSREV HSLLIVLLAL LAVYVTGVCV IFIVLFRSKS
     NTPRSRETKE DSKKKSARRI FQEIAQELYH KRYVETSHQP EQDGNYENRK ALPSPGRP
 
 
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