IHD1_CANAL
ID IHD1_CANAL Reviewed; 392 AA.
AC Q5A8I8; A0A1D8PQA4;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Induced during hyphae development protein 1;
DE AltName: Full=GPI-anchored protein 36;
DE Flags: Precursor;
GN Name=IHD1; Synonyms=PGA36; OrderedLocusNames=CAALFM_C603850CA;
GN ORFNames=CaO19.13183, CaO19.5760;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=12388749; DOI=10.1091/mbc.e02-05-0272;
RA Nantel A., Dignard D., Bachewich C., Harcus D., Marcil A., Bouin A.P.,
RA Sensen C.W., Hogues H., van het Hoog M., Gordon P., Rigby T., Benoit F.,
RA Tessier D.C., Thomas D.Y., Whiteway M.;
RT "Transcription profiling of Candida albicans cells undergoing the yeast-to-
RT hyphal transition.";
RL Mol. Biol. Cell 13:3452-3465(2002).
RN [5]
RP INDUCTION.
RX PubMed=15554973; DOI=10.1111/j.1365-2958.2004.04350.x;
RA Bensen E.S., Martin S.J., Li M., Berman J., Davis D.A.;
RT "Transcriptional profiling in Candida albicans reveals new adaptive
RT responses to extracellular pH and functions for Rim101p.";
RL Mol. Microbiol. 54:1335-1351(2004).
RN [6]
RP INDUCTION.
RX PubMed=16151249; DOI=10.1128/ec.4.9.1562-1573.2005;
RA Murillo L.A., Newport G., Lan C.Y., Habelitz S., Dungan J., Agabian N.M.;
RT "Genome-wide transcription profiling of the early phase of biofilm
RT formation by Candida albicans.";
RL Eukaryot. Cell 4:1562-1573(2005).
RN [7]
RP INDUCTION.
RX PubMed=15814840; DOI=10.1091/mbc.e05-01-0073;
RA Kadosh D., Johnson A.D.;
RT "Induction of the Candida albicans filamentous growth program by relief of
RT transcriptional repression: a genome-wide analysis.";
RL Mol. Biol. Cell 16:2903-2912(2005).
RN [8]
RP INDUCTION.
RX PubMed=16102003; DOI=10.1111/j.1365-2958.2005.04771.x;
RA Urban C., Xiong X., Sohn K., Schroppel K., Brunner H., Rupp S.;
RT "The moonlighting protein Tsa1p is implicated in oxidative stress response
RT and in cell wall biogenesis in Candida albicans.";
RL Mol. Microbiol. 57:1318-1341(2005).
RN [9]
RP INDUCTION.
RX PubMed=16267276; DOI=10.1091/mbc.e05-06-0502;
RA Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J., Liu H.;
RT "The Flo8 transcription factor is essential for hyphal development and
RT virulence in Candida albicans.";
RL Mol. Biol. Cell 17:295-307(2006).
RN [10]
RP INDUCTION.
RX PubMed=17605131; DOI=10.1002/yea.1514;
RA Sexton J.A., Brown V., Johnston M.;
RT "Regulation of sugar transport and metabolism by the Candida albicans Rgt1
RT transcriptional repressor.";
RL Yeast 24:847-860(2007).
RN [11]
RP INDUCTION.
RX PubMed=19032986; DOI=10.1016/j.fgb.2008.10.012;
RA Walker L.A., Maccallum D.M., Bertram G., Gow N.A., Odds F.C., Brown A.J.;
RT "Genome-wide analysis of Candida albicans gene expression patterns during
RT infection of the mammalian kidney.";
RL Fungal Genet. Biol. 46:210-219(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=20864472; DOI=10.1099/mic.0.044206-0;
RA Sosinska G.J., de Koning L.J., de Groot P.W., Manders E.M., Dekker H.L.,
RA Hellingwerf K.J., de Koster C.G., Klis F.M.;
RT "Mass spectrometric quantification of the adaptations in the wall proteome
RT of Candida albicans in response to ambient pH.";
RL Microbiology 157:136-146(2011).
RN [13]
RP INDUCTION.
RX PubMed=22544909; DOI=10.1128/ec.00103-12;
RA Fanning S., Xu W., Solis N., Woolford C.A., Filler S.G., Mitchell A.P.;
RT "Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and
RT in vivo.";
RL Eukaryot. Cell 11:896-904(2012).
RN [14]
RP INDUCTION.
RX PubMed=23242994; DOI=10.1091/mbc.e12-01-0065;
RA Carlisle P.L., Kadosh D.;
RT "A genome-wide transcriptional analysis of morphology determination in
RT Candida albicans.";
RL Mol. Biol. Cell 24:246-260(2013).
RN [15]
RP INDUCTION, AND FUNCTION.
RX PubMed=23516516; DOI=10.1371/journal.pone.0058613;
RA Martin R., Albrecht-Eckardt D., Brunke S., Hube B., Hunniger K., Kurzai O.;
RT "A core filamentation response network in Candida albicans is restricted to
RT eight genes.";
RL PLoS ONE 8:E58613-E58613(2013).
CC -!- FUNCTION: GPI-anchored cell wall protein that may be involved in cell
CC wall organization, hyphal growth, as well as in virulence.
CC {ECO:0000269|PubMed:23516516}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000269|PubMed:20864472}. Membrane {ECO:0000305}; Lipid-anchor,
CC GPI-anchor {ECO:0000305}.
CC -!- INDUCTION: Induced during yeast to hyphae transition, during biofilm
CC formation, during oralpharyngeal candidasis, and in response to serum.
CC Regulated BY FLO8, NRG1, RFG1, RGT1, TUP1, TSA1, and UME6.
CC {ECO:0000269|PubMed:12388749, ECO:0000269|PubMed:15554973,
CC ECO:0000269|PubMed:15814840, ECO:0000269|PubMed:16102003,
CC ECO:0000269|PubMed:16151249, ECO:0000269|PubMed:16267276,
CC ECO:0000269|PubMed:17605131, ECO:0000269|PubMed:19032986,
CC ECO:0000269|PubMed:22544909, ECO:0000269|PubMed:23242994,
CC ECO:0000269|PubMed:23516516}.
CC -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC reticulum and serves to target the protein to the cell surface. There,
CC the glucosamine-inositol phospholipid moiety is cleaved off and the
CC GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
CC -!- SIMILARITY: Belongs to the IHD1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017628; AOW30312.1; -; Genomic_DNA.
DR RefSeq; XP_718096.1; XM_713003.1.
DR AlphaFoldDB; Q5A8I8; -.
DR STRING; 237561.Q5A8I8; -.
DR PRIDE; Q5A8I8; -.
DR GeneID; 3640291; -.
DR KEGG; cal:CAALFM_C603850CA; -.
DR CGD; CAL0000194292; IHD1.
DR VEuPathDB; FungiDB:C6_03850C_A; -.
DR eggNOG; ENOG502SFRC; Eukaryota.
DR HOGENOM; CLU_703979_0_0_1; -.
DR OrthoDB; 1606124at2759; -.
DR PRO; PR:Q5A8I8; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..363
FT /note="Induced during hyphae development protein 1"
FT /id="PRO_0000424735"
FT PROPEP 364..392
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424736"
FT REGION 95..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 363
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 392 AA; 36945 MW; 8D504689B4DE290A CRC64;
MRPTPLFFAL LQIALAAKRA DQICNDHCSN AYQKQQSCGG TDDVSSQSAT LKCLCADESY
WSELASCDCS SYDSNVSAQD LRAYYCNVGV TGGSQGQSTS GDANAATNSN DATGTATDAA
AATNGNDGAS GTADANNANN TDGSGATDAS NTNNNGSTDT VNTNTAGSGS SETTAAAGAA
AGTAAGTNSA SDQANETGSD ATNAATGSDA SGTAATNTAS TASGATSGSG SDAAKKTGTN
TDSDSDTATK GSDATAGSMT TAASGLGATN GTSNSTGSHS GSMTSITTGS GFTNGTSSRS
GSGSGSSTRS GSNSDSSSSG SGSRSSSSAD SSDSDSGSGS SSTESGSGSG SGSSTSSGSG
SGSGSSTRSG GFAATIPTVT FGSLVALALN LL
