ID   API5A_XENLA             Reviewed;         524 AA.
AC   Q6DDM4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Apoptosis inhibitor 5-A;
DE            Short=API-5A;
GN   Name=api5-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be an antiapoptotic factor.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
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DR   EMBL; BC077529; AAH77529.1; -; mRNA.
DR   RefSeq; NP_001086837.1; NM_001093368.1.
DR   AlphaFoldDB; Q6DDM4; -.
DR   SMR; Q6DDM4; -.
DR   PRIDE; Q6DDM4; -.
DR   DNASU; 446672; -.
DR   GeneID; 446672; -.
DR   KEGG; xla:446672; -.
DR   CTD; 446672; -.
DR   Xenbase; XB-GENE-6256666; api5.L.
DR   OrthoDB; 1385954at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446672; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR008383; API5.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR12758; PTHR12758; 1.
DR   Pfam; PF05918; API5; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..524
FT                   /note="Apoptosis inhibitor 5-A"
FT                   /id="PRO_0000378095"
FT   REGION          1..360
FT                   /note="ARM-like and Heat-like helical repeats"
FT                   /evidence="ECO:0000250"
FT   REGION          440..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           455..476
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        440..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  58709 MW;  2E15BF5EC9BEF600 CRC64;
     MATVEELYRS YGILADAKDD VGQHKSAYQV IIDGVKGGAK EKRLAAQFIP KFFKHFPDLS
     DSALNAQLDL CEDEDVSIRR QAIKELSQFA TGENLPRVAD ILTQLLQSDD SAEFNLVNNA
     LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLATKMK TLPEETLTKE VDDYIFSESK
     KVLYDVTGEE FVLFMKILSA LKNLQTVSGR QQLVDLVSEQ AGLHQTLNPA DPDSVDRLLQ
     CMRQAVPLFS KNVHSTKFVT YFCEQVLPIL STLTSPAESI DVQLEVLKLL AEMSSFCGDM
     DKLESNLNKL FDKLLEFMPL PPEEVENGDT AANEEPKLQF SYVECLLFSF HQLGRKLPDF
     LIAKVDAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKSG DALKTEENKI KVVALKITNN
     INVLIKDLFH NPPSYKSTVT LSWKPVQRTP DSGQKRTSDE TSSTSPPKKP IVGPKRDSRQ
     IYNPPSGKYS ASVGAFSYEQ RGGFQGGRGR GWGGRGNRSR GRIY