ID   API5B_XENLA             Reviewed;         523 AA.
AC   Q7ZY79;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Apoptosis inhibitor 5-B;
DE            Short=API-5B;
GN   Name=api5-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be an antiapoptotic factor.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
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DR   EMBL; BC043906; AAH43906.1; -; mRNA.
DR   RefSeq; NP_001080226.1; NM_001086757.1.
DR   AlphaFoldDB; Q7ZY79; -.
DR   SMR; Q7ZY79; -.
DR   DNASU; 379918; -.
DR   GeneID; 379918; -.
DR   KEGG; xla:379918; -.
DR   CTD; 379918; -.
DR   Xenbase; XB-GENE-963042; api5.S.
DR   OMA; FIQCATA; -.
DR   OrthoDB; 1385954at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 379918; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR008383; API5.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR12758; PTHR12758; 1.
DR   Pfam; PF05918; API5; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..523
FT                   /note="Apoptosis inhibitor 5-B"
FT                   /id="PRO_0000378096"
FT   REGION          1..360
FT                   /note="ARM-like and Heat-like helical repeats"
FT                   /evidence="ECO:0000250"
FT   REGION          446..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           454..475
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        446..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  58632 MW;  099A85A43B59EAEC CRC64;
     MPTVEELYRN YGILADAKDD VGQHKSAYQV ILDGVKGGPK EKRLAAQFIP KFFKHFPDLS
     DAALNAQLDL CEDEDVSIRR QAIKELSQFA TGENLPRVAD ILTQLLQSDD SAEFNLVNNA
     LLSIFKMDAK GTLGGLFSQI LQGEDVVRER AIKFLATKMK TLPEDILTKE VDDYIFSESK
     KVLYDVTGEE FVLFMKILSA LKNLQTVSGR QQLVDLVSEQ AGLHQTLNPA DPDSVDRLLQ
     CMRQAVPLFS KNVHSTKFVT YFCEQVLPIL SSLTSPAEGI DVQLEVLKLL AEMSSFCGDM
     DKLESNLNKL FDKLLEFMPL PPEEVENGDS AANEEPKLQF SYVECLLFSF HQLGRKLPDF
     LIAKVDAEKL KDFKIRLQYF ARGLQVYIRQ LRLTLQGKSG DALKTEENKI KVVALKITNN
     INVLIKDLFH NPPSYKSTVT LSWKPVQKTD SGQKRMSDET SSTSPPKKPV VGPKRDSRQI
     YNPPSGKYSG NVGAFSYEQR GGFQGGRGRG WGGRGNRSRG RIY