ID   API5_CHICK              Reviewed;         523 AA.
AC   Q5ZMW3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Apoptosis inhibitor 5;
DE            Short=API-5;
GN   Name=API5; ORFNames=RCJMB04_1a12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Antiapoptotic factor that may have a role in protein
CC       assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Mainly nuclear.
CC   -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
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DR   EMBL; AJ719271; CAG30930.1; -; mRNA.
DR   RefSeq; NP_001006474.1; NM_001006474.1.
DR   AlphaFoldDB; Q5ZMW3; -.
DR   SMR; Q5ZMW3; -.
DR   STRING; 9031.ENSGALP00000012938; -.
DR   PaxDb; Q5ZMW3; -.
DR   Ensembl; ENSGALT00000061756; ENSGALP00000054380; ENSGALG00000037968.
DR   GeneID; 423168; -.
DR   KEGG; gga:423168; -.
DR   CTD; 8539; -.
DR   VEuPathDB; HostDB:geneid_423168; -.
DR   eggNOG; KOG2213; Eukaryota.
DR   GeneTree; ENSGT00390000010991; -.
DR   HOGENOM; CLU_037809_1_0_1; -.
DR   InParanoid; Q5ZMW3; -.
DR   OMA; FIQCATA; -.
DR   OrthoDB; 1385954at2759; -.
DR   PhylomeDB; Q5ZMW3; -.
DR   PRO; PR:Q5ZMW3; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000037968; Expressed in lung and 13 other tissues.
DR   ExpressionAtlas; Q5ZMW3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR008383; API5.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR12758; PTHR12758; 1.
DR   Pfam; PF05918; API5; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..523
FT                   /note="Apoptosis inhibitor 5"
FT                   /id="PRO_0000064633"
FT   REGION          1..360
FT                   /note="ARM-like and Heat-like helical repeats"
FT                   /evidence="ECO:0000250"
FT   REGION          446..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           454..475
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        446..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  58609 MW;  976156E4AFFB8ABC CRC64;
     MPTVEELYRN YGILADATET AGQHKDAYQV ILDGVKGGAK EKRLAAQFIP KFFKHFPELA
     DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGDNLPRVAD ILTQLLQSDD SAEFNLVNNA
     LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPEEVLTKE VEEFILAESK
     KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
     CTRQAVPLFS KNVHSTKFVT YFCEHVLPNL SALTTPVEGL DIQLEVLKLL AEMSSFCGDM
     EKLESNLKKL FDKLLEYMPL PPEEAENGEN AGGEEPKLQF SYVECLLYSF HQLGRKLPDF
     LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
     INVLIKDLFH IPPSYKSTVT LSWKPVQKAD ANQKRTSEDT TSSSPPKKAS AGPKRDARQI
     YNPPSGKYSS NLGSFSYEQR GGFRGGRGRG WGGRGNRSRG RIY