ID   API5_DICDI              Reviewed;         606 AA.
AC   Q54CL0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Apoptosis inhibitor 5 homolog;
DE            Short=API-5;
GN   Name=api5; ORFNames=DDB_G0292876;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May be an antiapoptotic factor.
CC   -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
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DR   EMBL; AAFI02000197; EAL60987.1; -; Genomic_DNA.
DR   RefSeq; XP_629406.1; XM_629404.1.
DR   AlphaFoldDB; Q54CL0; -.
DR   SMR; Q54CL0; -.
DR   STRING; 44689.DDB0191665; -.
DR   PaxDb; Q54CL0; -.
DR   EnsemblProtists; EAL60987; EAL60987; DDB_G0292876.
DR   GeneID; 8628925; -.
DR   KEGG; ddi:DDB_G0292876; -.
DR   dictyBase; DDB_G0292876; -.
DR   eggNOG; KOG2213; Eukaryota.
DR   HOGENOM; CLU_450893_0_0_1; -.
DR   InParanoid; Q54CL0; -.
DR   OMA; FIQCATA; -.
DR   PhylomeDB; Q54CL0; -.
DR   PRO; PR:Q54CL0; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR008383; API5.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR12758; PTHR12758; 1.
DR   Pfam; PF05918; API5; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Reference proteome.
FT   CHAIN           1..606
FT                   /note="Apoptosis inhibitor 5 homolog"
FT                   /id="PRO_0000378098"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..597
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  68973 MW;  84EF2E4B67C1EF08 CRC64;
     METTTTTTTA AATKGTNDAM ETSSSTTATP TTATVVPQVV RNDEYINTFY DIANKLDTNP
     SFPDDDKLFS KIIELSSKTK QTKKLSPQFI SKYFKRFPTL QEKAIDCLID LFDSSDEDVI
     MRVNALKAIP TICRDNPDHI AKLVDILSQL LNTDSKVEAE HTKNSLIELY KLNSVTTLNS
     FLTFLESEES SMEDQPASST LLSFLKESII PLVRTEYSKS SIETQTFFRV RILKLIAKCT
     STTELDLLFQ LLECFTQYKV QETITDLETN VLPVIESQSL DTIRKKLINF TKILLFKSKK
     PHTEINSNKL FDLYLNKIFP KVNELDETNK TELVSVFSQV TPHMTQEISM QFLEPVYNLF
     KATVPSKTTT PVADVDLQFT IVEALLFALS SIGSKSTSSL CKLCGFKLVT GQPSDMNADP
     VKYEDFLGRH RFLDEKCRET LGKAKKAIPN LGNPKDKAQL KLAQKTLLST QNILTIMQNL
     LKSPPVTNIN NLVISSTIFK GKQNLIHNVS PVFKPQQHQH QHQQQQVQQK QYQKYQAQQQ
     QQQNIPIQRN QQQQQQQKSN RYQPYVTPGR RHQDLDKPKQ DGVEVHYYSE KHNKPSSFKG
     RGPKSY