API5_DROME
ID API5_DROME Reviewed; 536 AA.
AC Q9V431;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Apoptosis inhibitor 5 homolog {ECO:0000303|PubMed:17112319};
DE Short=API-5 {ECO:0000303|PubMed:17112319};
DE AltName: Full=Antiapoptosis clone 11 protein homolog {ECO:0000303|PubMed:17112319};
DE Short=AAC-11 {ECO:0000303|PubMed:17112319};
DE AltName: Full=Protein cassowary {ECO:0000312|FlyBase:FBgn0286781};
GN Name=cass {ECO:0000312|FlyBase:FBgn0286781};
GN Synonyms=Aac11 {ECO:0000303|PubMed:17112319};
GN ORFNames=CG6582 {ECO:0000312|FlyBase:FBgn0286781};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17112319; DOI=10.1371/journal.pgen.0020196;
RA Morris E.J., Michaud W.A., Ji J.Y., Moon N.S., Rocco J.W., Dyson N.J.;
RT "Functional identification of Api5 as a suppressor of E2F-dependent
RT apoptosis in vivo.";
RL PLoS Genet. 2:E196-E196(2006).
CC -!- FUNCTION: Antiapoptotic factor. Also known to efficiently suppress
CC E2F1-induced apoptosis. {ECO:0000269|PubMed:17112319}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Enhanced E2f1-induced apoptosis.
CC {ECO:0000269|PubMed:17112319}.
CC -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF160921; AAD46861.1; -; mRNA.
DR EMBL; AE014134; AAF53618.1; -; Genomic_DNA.
DR RefSeq; NP_477454.1; NM_058106.5.
DR AlphaFoldDB; Q9V431; -.
DR SMR; Q9V431; -.
DR BioGRID; 61049; 5.
DR IntAct; Q9V431; 2.
DR MINT; Q9V431; -.
DR STRING; 7227.FBpp0080554; -.
DR PaxDb; Q9V431; -.
DR PRIDE; Q9V431; -.
DR EnsemblMetazoa; FBtr0081001; FBpp0080554; FBgn0286781.
DR GeneID; 35053; -.
DR KEGG; dme:Dmel_CG6582; -.
DR UCSC; CG6582-RA; d. melanogaster.
DR CTD; 35053; -.
DR FlyBase; FBgn0286781; cass.
DR VEuPathDB; VectorBase:FBgn0286781; -.
DR eggNOG; KOG2213; Eukaryota.
DR GeneTree; ENSGT00390000010991; -.
DR HOGENOM; CLU_037809_1_0_1; -.
DR InParanoid; Q9V431; -.
DR OMA; FIQCATA; -.
DR OrthoDB; 1385954at2759; -.
DR PhylomeDB; Q9V431; -.
DR BioGRID-ORCS; 35053; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Aac11; fly.
DR GenomeRNAi; 35053; -.
DR PRO; PR:Q9V431; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0286781; Expressed in brain and 25 other tissues.
DR Genevisible; Q9V431; DM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR008383; API5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR PANTHER; PTHR12758; PTHR12758; 1.
DR Pfam; PF05918; API5; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Nucleus; Reference proteome.
FT CHAIN 1..536
FT /note="Apoptosis inhibitor 5 homolog"
FT /id="PRO_0000378097"
FT REGION 462..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 59930 MW; 207BCC1F52BB69BF CRC64;
MDNIERLYKC YEILSEAGDK ISEHVDEYKE ILKAVKGTSK EKRLASQFIG NFFKHFPDLA
DTAIDAQFDL CEDDDTQIRR QAIKDLPKLC QGNADATIRV GDTLAQLLIL DDPTELQQVN
NSLLAIIKLD TKSSIAGLFQ QISTGDETTR ERCLKFIATK LLTMGPTVIT KEIEDYIVEE
IKKALQDVTA DEFHLCMTIL GATKLGSTIT GHAELVKLAT EQAELNNTDA DIIAVDDEVV
ERFIQCASAA APYFSKTIKS TAFVAHVCDK LLPIKTWNMI ATAVSQDQIQ LRLLKVFAEM
ITNTDKLDNA SERINAVYNV LLEYMPLPKL SDEDLGDTPP SFQFSHAECL LYALHTLGKN
HPNSLSFVED AEKLKDFRAR LQYLARGTQG YIKKLEESLK GKTGEELKTE ENQLKQTALK
TTSNINILIR DLFHSPPIFK HDIVLSWIVP KNNKLGKRHA PITFGEKAAA NGKDKDQEPE
KKSRPSNDQK FYSPPSGKYS NKVNQSYGNN NRTRQRGGGG GGGSGGGYRN RRFNKY
