API5_ORYSJ
ID API5_ORYSJ Reviewed; 537 AA.
AC Q6Z6S1; Q0E1R8;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Apoptosis inhibitor 5-like protein API5;
DE AltName: Full=Protein APOPTOSIS INHIBITOR 5 {ECO:0000303|PubMed:21467577};
GN Name=API5 {ECO:0000303|PubMed:21467577};
GN OrderedLocusNames=Os02g0313400 {ECO:0000312|EMBL:BAF08570.1},
GN LOC_Os02g20930 {ECO:0000305};
GN ORFNames=OsJ_06432 {ECO:0000312|EMBL:EAZ22757.1},
GN P0705A04.11 {ECO:0000312|EMBL:BAD15974.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP FUNCTION, INTERACTION WITH AIP1 AND AIP2, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=21467577; DOI=10.1105/tpc.110.082636;
RA Li X., Gao X., Wei Y., Deng L., Ouyang Y., Chen G., Li X., Zhang Q., Wu C.;
RT "Rice APOPTOSIS INHIBITOR5 coupled with two DEAD-box adenosine 5'-
RT triphosphate-dependent RNA helicases regulates tapetum degeneration.";
RL Plant Cell 23:1416-1434(2011).
CC -!- FUNCTION: Putative anti-apoptotic factor involved in the regulation of
CC tapetal programmed cell death (PCD) and degeneration during anther
CC development. Interacts directly with the DEAD-box ATP-dependent RNA
CC helicases AIP1 and AIP2 that form dimers and bind the promoter region
CC of the cysteine protease CP1 involved in tapetum PCD.
CC {ECO:0000269|PubMed:21467577}.
CC -!- SUBUNIT: Interacts with AIP1 and AIP2. {ECO:0000269|PubMed:21467577}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21467577}.
CC -!- DEVELOPMENTAL STAGE: During anther development, expressed in tapetal
CC cells, parietal anther wall layers and microsporocytes from late stages
CC 8 to stage 10. {ECO:0000269|PubMed:21467577}.
CC -!- DISRUPTION PHENOTYPE: Male sterility due to lack of tapetal programmed
CC cell death (PCD) and degeneration, leading to defects in formation of
CC male gametophytes. {ECO:0000269|PubMed:21467577}.
CC -!- SIMILARITY: Belongs to the API5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF08570.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAS78330.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP004891; BAD15974.1; -; Genomic_DNA.
DR EMBL; AP008208; BAF08570.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014958; BAS78330.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM000139; EAZ22757.1; -; Genomic_DNA.
DR RefSeq; XP_015627484.1; XM_015771998.1.
DR AlphaFoldDB; Q6Z6S1; -.
DR SMR; Q6Z6S1; -.
DR STRING; 4530.OS02T0313400-01; -.
DR PRIDE; Q6Z6S1; -.
DR GeneID; 4329135; -.
DR KEGG; osa:4329135; -.
DR eggNOG; KOG2213; Eukaryota.
DR InParanoid; Q6Z6S1; -.
DR OrthoDB; 1385954at2759; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000007752; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0009555; P:pollen development; IMP:UniProtKB.
DR GO; GO:0043067; P:regulation of programmed cell death; IMP:UniProtKB.
DR InterPro; IPR008383; API5.
DR InterPro; IPR016024; ARM-type_fold.
DR PANTHER; PTHR12758; PTHR12758; 1.
DR Pfam; PF05918; API5; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..537
FT /note="Apoptosis inhibitor 5-like protein API5"
FT /id="PRO_0000436460"
FT REGION 9..363
FT /note="ARM-like and Heat-like helical repeats"
FT /evidence="ECO:0000305"
FT REGION 465..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 59986 MW; D5C600D408E00883 CRC64;
MAASDADAAE VERLYELGER LSSAKDKSQH AADYEAIISA VKGQSVKAKQ LAAQLIPRFF
RSFPALAPRA MEAMFDLVDM EELATRIQAI RGFPLLAKDA EFVSKIADIL GQLLASEENV
ERDAVHKALM SLIRQDVKSS LQPLFKHVES GSEIREKVIC FLKDKVFPVK AELLKPQAEM
ERYITDLIKK SVLDVTGLEF KLFMDFLRSL SIFGDSAPRE SFQELIEIIQ AQADLDAQFN
VSDIDHIERW TSCMYMALPI FMRGGSSSKF LNYFVKQIVP VFDKIPEEKK LDLLKTVAAS
SPYATAQDAR QLLPPVVQLL KKYMPGKKVE DINHNYVECL MYIFHHLAHK TPNTTNSLCG
YKIVTGQPSD RLGEDFSEHY KDFTERLTGT EETVRAVSKR LTQGMADFNK AISSAKTEEE
KTKIKSDQQK STMTMRAYNN ILAMAQPLRA KSPLFIGDKK ITLSWMEQPK KPAPTTTGGK
RSQPATNGNT PASKKGRGEG AARNQLVNRA FEGLSRGGRG SGRGRGRGGR GRGWGYR
