ID   IHFA_PSEAE              Reviewed;         100 AA.
AC   Q51472;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Integration host factor subunit alpha;
DE            Short=IHF-alpha;
GN   Name=ihfA; Synonyms=himA; OrderedLocusNames=PA2738;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7867950; DOI=10.1016/0378-1119(94)00875-s;
RA   Delic-Attree I., Toussaint B., Vignais P.M.;
RT   "Cloning and sequence analyses of the genes coding for the integration host
RT   factor (IHF) and HU proteins of Pseudomonas aeruginosa.";
RL   Gene 154:61-64(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-16.
RC   STRAIN=CHA;
RX   PubMed=8216322; DOI=10.1006/bbrc.1993.2265;
RA   Toussaint B., Delic-Attree I., Vignais P.M.;
RT   "Pseudomonas aeruginosa contains an IHF-like protein that binds to the algD
RT   promoter.";
RL   Biochem. Biophys. Res. Commun. 196:416-421(1993).
CC   -!- FUNCTION: This protein is one of the two subunits of integration host
CC       factor, a specific DNA-binding protein that functions in genetic
CC       recombination as well as in transcriptional and translational control.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- MISCELLANEOUS: In vitro, binds to the algD promoter.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; L35258; AAA65949.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06126.1; -; Genomic_DNA.
DR   PIR; JC4062; JC4062.
DR   RefSeq; NP_251428.1; NC_002516.2.
DR   RefSeq; WP_003090661.1; NZ_QZGE01000011.1.
DR   AlphaFoldDB; Q51472; -.
DR   SMR; Q51472; -.
DR   STRING; 287.DR97_5224; -.
DR   PaxDb; Q51472; -.
DR   PRIDE; Q51472; -.
DR   DNASU; 882954; -.
DR   EnsemblBacteria; AAG06126; AAG06126; PA2738.
DR   GeneID; 61671669; -.
DR   GeneID; 882954; -.
DR   KEGG; pae:PA2738; -.
DR   PATRIC; fig|208964.12.peg.2863; -.
DR   PseudoCAP; PA2738; -.
DR   HOGENOM; CLU_105066_1_3_6; -.
DR   InParanoid; Q51472; -.
DR   OMA; IYVRGFG; -.
DR   PhylomeDB; Q51472; -.
DR   BioCyc; PAER208964:G1FZ6-2777-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   CollecTF; EXPREG_00000e50; -.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEP:CollecTF.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   CDD; cd13835; IHF_A; 1.
DR   Gene3D; 4.10.520.10; -; 1.
DR   HAMAP; MF_00380; IHF_alpha; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   InterPro; IPR005684; IHF_alpha.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   TIGRFAMs; TIGR00987; himA; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA recombination; DNA-binding;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8216322"
FT   CHAIN           2..100
FT                   /note="Integration host factor subunit alpha"
FT                   /id="PRO_0000105017"
FT   REGION          54..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   100 AA;  11471 MW;  7F74B2726E57E95E CRC64;
     MGALTKAEIA ERLYEELGLN KREAKELVEL FFEEIRQALE HNEQVKLSGF GNFDLRDKRQ
     RPGRNPKTGE EIPITARRVV TFRPGQKLKA RVEAYAGTKS