ID   APIBP_ACTSZ             Reviewed;         310 AA.
AC   A6VKQ8;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=D-apiose import binding protein {ECO:0000305};
DE   AltName: Full=D-apiose binding SBP {ECO:0000303|PubMed:29867142};
DE   Flags: Precursor;
GN   OrderedLocusNames=Asuc_0175 {ECO:0000312|EMBL:ABR73555.1};
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
RN   [2]
RP   FUNCTION, AND SUBSTRATE-BINDING.
RX   PubMed=29867142; DOI=10.1038/s41589-018-0067-7;
RA   Carter M.S., Zhang X., Huang H., Bouvier J.T., Francisco B.S.,
RA   Vetting M.W., Al-Obaidi N., Bonanno J.B., Ghosh A., Zallot R.G.,
RA   Andersen H.M., Almo S.C., Gerlt J.A.;
RT   "Functional assignment of multiple catabolic pathways for D-apiose.";
RL   Nat. Chem. Biol. 14:696-705(2018).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in D-apiose
CC       import (Probable). Binds D-apiose, D-ribose and D-ribulose
CC       (PubMed:29867142). {ECO:0000269|PubMed:29867142,
CC       ECO:0000305|PubMed:29867142}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000746; ABR73555.1; -; Genomic_DNA.
DR   RefSeq; WP_011978831.1; NC_009655.1.
DR   AlphaFoldDB; A6VKQ8; -.
DR   SMR; A6VKQ8; -.
DR   STRING; 339671.Asuc_0175; -.
DR   EnsemblBacteria; ABR73555; ABR73555; Asuc_0175.
DR   KEGG; asu:Asuc_0175; -.
DR   eggNOG; COG1879; Bacteria.
DR   HOGENOM; CLU_037628_3_2_6; -.
DR   OMA; YPEMKMV; -.
DR   OrthoDB; 1378040at2; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Reference proteome; Signal; Sugar transport; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..310
FT                   /note="D-apiose import binding protein"
FT                   /id="PRO_5002701886"
FT   BINDING         35
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         111..112
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         158..160
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         164
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         214
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         239
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
FT   BINDING         260
FT                   /ligand="D-apiofuranose"
FT                   /ligand_id="ChEBI:CHEBI:141215"
FT                   /evidence="ECO:0000250|UniProtKB:Q2JZQ5"
SQ   SEQUENCE   310 AA;  33123 MW;  3E02C228F3327073 CRC64;
     MKLLKASLVA LSLAASTFVY ADNGLIAIIT PSHDNPFFKA EADGAKQKAE ELGYTTLVAS
     HDDDANKQDQ LISTAVSRKA KAIILDNAGS DVTVGALEKA KAAGVPAFLI DREINKTGVA
     VSQIVSNNYQ GAQLSAEKFV ELMGEKGQYV ELLGRESDTN ASVRSQGFHE IIDEYPEMKM
     VAQQTANWSQ TEGFSRMESI LQANPNIKGV ISGNDTMALG AEAALKAAGR TDVIVVGFDG
     SDYVRDSILA GGNIKATALQ PAWDQAQEAV VQADKYIRTG STGKEEKQLM DCILIDSSNA
     KKLNKFSLSK