IHFA_SALTI
ID IHFA_SALTI Reviewed; 99 AA.
AC P0A1S1; P15430;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Integration host factor subunit alpha;
DE Short=IHF-alpha;
GN Name=ihfA; Synonyms=himA; OrderedLocusNames=STY1771, t1220;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: This protein is one of the two subunits of integration host
CC factor, a specific DNA-binding protein that functions in genetic
CC recombination as well as in transcriptional and translational control.
CC {ECO:0000250}.
CC -!- FUNCTION: IHF also plays a crucial role in the lysogenic life cycle of
CC bacteriophage lambda, as it is required not only in the recombination
CC reaction, which inserts lambda DNA into the E.coli chromosome, but also
CC for the synthesis of int and cI repressor, two phage proteins necessary
CC for DNA insertion and repression, respectively. The synthesis of int
CC and cI proteins is regulated indirectly by IHF via translational
CC control of the lambda cII protein (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; AL513382; CAD02013.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68875.1; -; Genomic_DNA.
DR RefSeq; NP_456172.1; NC_003198.1.
DR RefSeq; WP_001229266.1; NZ_WSUR01000011.1.
DR AlphaFoldDB; P0A1S1; -.
DR SMR; P0A1S1; -.
DR STRING; 220341.16502851; -.
DR EnsemblBacteria; AAO68875; AAO68875; t1220.
DR GeneID; 66755750; -.
DR KEGG; stt:t1220; -.
DR KEGG; sty:STY1771; -.
DR PATRIC; fig|220341.7.peg.1783; -.
DR eggNOG; COG0776; Bacteria.
DR HOGENOM; CLU_105066_1_3_6; -.
DR OMA; IYVRGFG; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR CDD; cd13835; IHF_A; 1.
DR Gene3D; 4.10.520.10; -; 1.
DR HAMAP; MF_00380; IHF_alpha; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR InterPro; IPR005684; IHF_alpha.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR TIGRFAMs; TIGR00987; himA; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 3: Inferred from homology;
KW DNA recombination; DNA-binding; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..99
FT /note="Integration host factor subunit alpha"
FT /id="PRO_0000105025"
FT REGION 49..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 11368 MW; 278B782BCD79D754 CRC64;
MALTKAEMSE YLFDKLGLSK RDAKELVELF FEEIRRALEN GEQVKLSGFG NFDLRDKNQR
PGRNPKTGED IPITARRVVT FRPGQKLKSR VENASPKEE