ID   IHFA_SALTY              Reviewed;          99 AA.
AC   P0A1S0; P15430;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Integration host factor subunit alpha;
DE            Short=IHF-alpha;
GN   Name=ihfA; Synonyms=himA; OrderedLocusNames=STM1339;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2685752; DOI=10.1093/nar/17.21.8880;
RA   Li Z.J., Hillyard D., Higgins P.;
RT   "Nucleotide sequence of the Salmonella typhimurium himA gene.";
RL   Nucleic Acids Res. 17:8880-8880(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: This protein is one of the two subunits of integration host
CC       factor, a specific DNA-binding protein that functions in genetic
CC       recombination as well as in transcriptional and translational control.
CC   -!- FUNCTION: IHF also plays a crucial role in the lysogenic life cycle of
CC       bacteriophage lambda, as it is required not only in the recombination
CC       reaction, which inserts lambda DNA into the E.coli chromosome, but also
CC       for the synthesis of int and cI repressor, two phage proteins necessary
CC       for DNA insertion and repression, respectively. The synthesis of int
CC       and cI proteins is regulated indirectly by IHF via translational
CC       control of the lambda cII protein.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; X16739; CAA34713.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20264.1; -; Genomic_DNA.
DR   PIR; S09608; S09608.
DR   RefSeq; NP_460305.1; NC_003197.2.
DR   RefSeq; WP_001229266.1; NC_003197.2.
DR   AlphaFoldDB; P0A1S0; -.
DR   SMR; P0A1S0; -.
DR   STRING; 99287.STM1339; -.
DR   PaxDb; P0A1S0; -.
DR   EnsemblBacteria; AAL20264; AAL20264; STM1339.
DR   GeneID; 1252857; -.
DR   GeneID; 66755750; -.
DR   KEGG; stm:STM1339; -.
DR   PATRIC; fig|99287.12.peg.1422; -.
DR   HOGENOM; CLU_105066_1_3_6; -.
DR   OMA; IYVRGFG; -.
DR   PhylomeDB; P0A1S0; -.
DR   BioCyc; SENT99287:STM1339-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   CDD; cd13835; IHF_A; 1.
DR   Gene3D; 4.10.520.10; -; 1.
DR   HAMAP; MF_00380; IHF_alpha; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   InterPro; IPR005684; IHF_alpha.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   TIGRFAMs; TIGR00987; himA; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Translation regulation.
FT   CHAIN           1..99
FT                   /note="Integration host factor subunit alpha"
FT                   /id="PRO_0000105026"
FT   REGION          49..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        53
FT                   /note="D -> G (in Ref. 1; CAA34713)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93
FT                   /note="N -> S (in Ref. 1; CAA34713)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   99 AA;  11368 MW;  278B782BCD79D754 CRC64;
     MALTKAEMSE YLFDKLGLSK RDAKELVELF FEEIRRALEN GEQVKLSGFG NFDLRDKNQR
     PGRNPKTGED IPITARRVVT FRPGQKLKSR VENASPKEE