ID   API_ACAVI               Reviewed;         234 AA.
AC   Q9TXA7;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2003, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Filarial antigen Av33;
DE   Flags: Precursor;
OS   Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX   NCBI_TaxID=6277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8433724; DOI=10.1016/0166-6851(93)90212-g;
RA   Willenbucher J., Hofle W., Lucius R.;
RT   "The filarial antigens Av33/Ov33-3 show striking similarities to the major
RT   pepsin inhibitor from Ascaris suum.";
RL   Mol. Biochem. Parasitol. 57:349-351(1993).
CC   -!- FUNCTION: Aspartyl protease inhibitor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I33 family.
CC       {ECO:0000305}.
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DR   PIR; A48577; A48577.
DR   AlphaFoldDB; Q9TXA7; -.
DR   SMR; Q9TXA7; -.
DR   MEROPS; I33.002; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1120.50; -; 2.
DR   InterPro; IPR010480; Pepsin-I3.
DR   InterPro; IPR038412; Pepsin-I3_sf.
DR   Pfam; PF06394; Pepsin-I3; 2.
PE   3: Inferred from homology;
KW   Aspartic protease inhibitor; Disulfide bond; Protease inhibitor; Secreted;
KW   Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..234
FT                   /note="Filarial antigen Av33"
FT                   /id="PRO_0000002395"
FT   REGION          204..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        135..230
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   234 AA;  26275 MW;  883E0728919E2122 CRC64;
     MKILSCLLLC TITVLEGNVM NRHNKRFAGF NVAGIGGTAG CVVVDNKLFA NGFFLRELTA
     EEQREFAQYV EESNKYKEEL KVSLEERRKG WQIARQSEKG AKILSTITEK NLPKPPKKPS
     FCTAADTTQY YFDGCMVQNN KIFVGQSYVR DLTADEAKEL KSFDVKMTAY QKYLSSSIQQ
     QMNSLFGDKT NLLNLFTNTH LESTSQASEA TTIPTTTQTP VEAPETPSFC VPIY