IHFA_VIBC3
ID IHFA_VIBC3 Reviewed; 98 AA.
AC A5F1W7; C3LZY3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Integration host factor subunit alpha {ECO:0000255|HAMAP-Rule:MF_00380};
DE Short=IHF-alpha {ECO:0000255|HAMAP-Rule:MF_00380};
GN Name=ihfA {ECO:0000255|HAMAP-Rule:MF_00380};
GN Synonyms=himA {ECO:0000255|HAMAP-Rule:MF_00380};
GN OrderedLocusNames=VC0395_A0846, VC395_1341;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: This protein is one of the two subunits of integration host
CC factor, a specific DNA-binding protein that functions in genetic
CC recombination as well as in transcriptional and translational control.
CC {ECO:0000255|HAMAP-Rule:MF_00380}.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000255|HAMAP-
CC Rule:MF_00380}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000255|HAMAP-Rule:MF_00380}.
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DR EMBL; CP000627; ABQ19858.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP09349.1; -; Genomic_DNA.
DR RefSeq; WP_001229260.1; NZ_JAACZH010000002.1.
DR AlphaFoldDB; A5F1W7; -.
DR SMR; A5F1W7; -.
DR STRING; 345073.VC395_1341; -.
DR EnsemblBacteria; ABQ19858; ABQ19858; VC0395_A0846.
DR GeneID; 57739897; -.
DR KEGG; vco:VC0395_A0846; -.
DR KEGG; vcr:VC395_1341; -.
DR PATRIC; fig|345073.21.peg.1305; -.
DR eggNOG; COG0776; Bacteria.
DR HOGENOM; CLU_105066_1_3_6; -.
DR OMA; IYVRGFG; -.
DR Proteomes; UP000000249; Chromosome 2.
DR CollecTF; EXPREG_00000230; -.
DR GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IPI:CollecTF.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:CollecTF.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR CDD; cd13835; IHF_A; 1.
DR Gene3D; 4.10.520.10; -; 1.
DR HAMAP; MF_00380; IHF_alpha; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR InterPro; IPR005684; IHF_alpha.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR TIGRFAMs; TIGR00987; himA; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 3: Inferred from homology;
KW DNA recombination; DNA-binding; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..98
FT /note="Integration host factor subunit alpha"
FT /id="PRO_1000072174"
FT REGION 51..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 11120 MW; 69462CF6BB124906 CRC64;
MALTKAELAE ALFEQLGMSK RDAKDTVEVF FEEIRKALES GEQVKLSGFG NFDLRDKNER
PGRNPKTGED IPITARRVVT FRPGQKLKAR VENIKVEK
