ID   API_ONCVO               Reviewed;         235 AA.
AC   P21250;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Immunodominant antigen Ov33-3;
DE   Flags: Precursor;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3171478; DOI=10.1084/jem.168.3.1199;
RA   Lucius R., Erondu N., Kern A., Donelson J.E.;
RT   "Molecular cloning of an immunodominant antigen of Onchocerca volvulus.";
RL   J. Exp. Med. 168:1199-1204(1988).
CC   -!- FUNCTION: Aspartyl protease inhibitor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Reproductive organs and muscle.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I33 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA31690.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X13313; CAA31690.1; ALT_INIT; mRNA.
DR   PIR; JL0075; JL0075.
DR   AlphaFoldDB; P21250; -.
DR   SMR; P21250; -.
DR   STRING; 6282.P21250; -.
DR   MEROPS; I33.002; -.
DR   HOGENOM; CLU_099985_0_0_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1120.50; -; 2.
DR   InterPro; IPR010480; Pepsin-I3.
DR   InterPro; IPR038412; Pepsin-I3_sf.
DR   Pfam; PF06394; Pepsin-I3; 2.
PE   2: Evidence at transcript level;
KW   Aspartic protease inhibitor; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..235
FT                   /note="Immunodominant antigen Ov33-3"
FT                   /id="PRO_0000002397"
FT   DISULFID        135..231
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   235 AA;  26277 MW;  5186D4934DCF2643 CRC64;
     MKILFCLLLL AITALEAGVV KRYNKRFAGF NVAGIGGNAG CVVVDNKLFA NSFFLRELTT
     EEQRELAQYI EDSNRYKEEV KESLEERRKG WQLARDGKED SKVLSALAEK KLPKPPKKPS
     FCSAGDTTQY YFDGCMVQND KIYVGRAYVR DLTPDEVTQL KTFDAKMTAY QKYLSSTIQK
     QVDSLFGEKS NLFNLFADTR TEATSQASDD ATAGATTTQA PVEAPEPPHF CVAIY