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APJB_XENLA
ID   APJB_XENLA              Reviewed;         363 AA.
AC   Q2TAD5; A1XP43; Q05BH5; Q7T0X4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Apelin receptor B;
DE   AltName: Full=Angiotensin receptor-like 1b;
DE   AltName: Full=Angiotensin receptor-related protein B;
DE   AltName: Full=G-protein coupled receptor APJ-B;
DE            Short=APJb;
GN   Name=aplnr-b; Synonyms=agtrl1-b, agtrl1b {ECO:0000312|EMBL:AAI10979.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABF19732.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Embryo {ECO:0000312|EMBL:ABF19732.1};
RX   PubMed=17412318; DOI=10.1016/j.ydbio.2007.03.004;
RA   Kaelin R.E., Kretz M.P., Meyer A.M., Kispert A., Heppner F.L.,
RA   Braendli A.W.;
RT   "Paracrine and autocrine mechanisms of apelin signaling govern embryonic
RT   and tumor angiogenesis.";
RL   Dev. Biol. 305:599-614(2007).
RN   [2] {ECO:0000312|EMBL:AAI10979.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH46659.1}, and
RC   Spleen {ECO:0000312|EMBL:AAI10979.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for apelin receptor early endogenous ligand (apela)
CC       and apelin (apln) hormones coupled to G proteins that inhibit adenylate
CC       cyclase activity (PubMed:17412318). Plays a key role in early
CC       development such as gastrulation, blood vessels formation and heart
CC       morphogenesis by acting as a receptor for apela hormone, promoting
CC       endoderm and mesendoderm cell migration and regulating the migration of
CC       cells fated to become myocardial progenitors, respectively (By
CC       similarity). Promotes angioblast migration toward the embryonic
CC       midline, i.e. the position of the future vessel formation, during
CC       vasculogenesis (By similarity). May promote sinus venosus (SV)-derived
CC       endothelial cells migration into the developing heart to promote
CC       coronary blood vessel development (By similarity). Required for
CC       cardiovascular development, particularly for intersomitic vein
CC       angiogenesis by acting as a receptor for apln hormone
CC       (PubMed:17412318). Also plays a role in various processes in adults
CC       such as regulation of blood vessel formation, blood pressure, heart
CC       contractility, and heart failure. Acts upstream of the i/o type of G-
CC       alpha proteins in the differentiation of endothelium, erythroid cells,
CC       myeloid cells and cardiomyocytes (By similarity).
CC       {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:P79960,
CC       ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08,
CC       ECO:0000269|PubMed:17412318}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17412318};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:17412318}.
CC       Note=Internalized to the cytoplasm after exposure to apelin (apln)
CC       (PubMed:17412318). After exposure to apelin receptor early endogenous
CC       ligand (apela), internalized from the cell surface into an endosomal
CC       recycling compartment, from where it is recycled to the cell membrane
CC       (By similarity). {ECO:0000250|UniProtKB:P35414,
CC       ECO:0000269|PubMed:17412318}.
CC   -!- TISSUE SPECIFICITY: Expressed in all blood vessels including the
CC       posterior cardinal vein, intersomitic veins and the vitelline vein
CC       network. {ECO:0000269|PubMed:17412318}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH55998.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; DQ473442; ABF19732.1; -; mRNA.
DR   EMBL; BC046659; AAH46659.1; -; mRNA.
DR   EMBL; BC055998; AAH55998.1; ALT_FRAME; mRNA.
DR   EMBL; BC110978; AAI10979.1; -; mRNA.
DR   RefSeq; NP_001079847.1; NM_001086378.1.
DR   AlphaFoldDB; Q2TAD5; -.
DR   SMR; Q2TAD5; -.
DR   DNASU; 379537; -.
DR   GeneID; 379537; -.
DR   KEGG; xla:379537; -.
DR   CTD; 379537; -.
DR   Xenbase; XB-GENE-6255483; aplnr.S.
DR   OrthoDB; 788659at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 379537; Expressed in lung and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0060182; F:apelin receptor activity; IDA:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IMP:UniProtKB.
DR   GO; GO:0060183; P:apelin receptor signaling pathway; IMP:UniProtKB.
DR   GO; GO:0001568; P:blood vessel development; ISS:UniProtKB.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR   GO; GO:0043951; P:negative regulation of cAMP-mediated signaling; ISS:UniProtKB.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:1904325; P:positive regulation of inhibitory G protein-coupled receptor phosphorylation; ISS:UniProtKB.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR   InterPro; IPR003904; Apelin_rcpt.
DR   InterPro; IPR000248; ATII_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24228:SF31; PTHR24228:SF31; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00241; ANGIOTENSINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Cell membrane; Developmental protein; Differentiation;
KW   G-protein coupled receptor; Gastrulation; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..363
FT                   /note="Apelin receptor B"
FT                   /id="PRO_0000311701"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        271..297
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..363
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        14
FT                   /note="E -> D (in Ref. 1; ABF19732 and 2; AAH46659)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        244
FT                   /note="E -> D (in Ref. 1; ABF19732)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   363 AA;  40920 MW;  833D915AB777E9F9 CRC64;
     MESEGFSATT EQYEYYDYAN ETGLQPCDET DWDFSYSLLP VFYMIVFVLG LSGNGVVIFT
     VWKAKPKRRS ADTYIGNLAL ADLAFVVTLP LWATYTALGF HWPFGSALCK LSSYLVLLNM
     FASVFCLTCL SFDRYLAIVH SLSSAKLRSR SSILVSLAVI WLFSGLLALP SLILRDTRVE
     GNNTICDLDF SGVSSKENEN FWIGGLSILT TVPGFLLPLL LMTIFYCFIG GKVTMHFQNL
     KKEEQKKKRL LKIIITLVVV FAICWLPFHI LKTIHFLDLM GFLELSCSAQ NIIVSLHPYA
     TCLAYVNSCL NPFLYAFFDL RFRSQCFFFF GFKKVLQGHL SNTSSSLSAQ TQKSEIHSLA
     TKV
 
 
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