APJ_MACMU
ID APJ_MACMU Reviewed; 380 AA.
AC O97666;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Apelin receptor;
DE AltName: Full=Angiotensin receptor-like 1;
DE AltName: Full=G-protein coupled receptor APJ;
GN Name=APLNR; Synonyms=AGTRL1, APJ;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Spleen;
RX PubMed=11461684; DOI=10.1089/088922201750290104;
RA Margulies B.J., Hauer D.A., Clements J.E.;
RT "Identification and comparison of eleven rhesus macaque chemokine
RT receptors.";
RL AIDS Res. Hum. Retroviruses 17:981-986(2001).
CC -!- FUNCTION: Receptor for apelin receptor early endogenous ligand (APELA)
CC and apelin (APLN) hormones coupled to G proteins that inhibit adenylate
CC cyclase activity. Plays a key role in early development such as
CC gastrulation, blood vessels formation and heart morphogenesis by acting
CC as a receptor for APELA hormone. May promote angioblast migration
CC toward the embryonic midline, i.e. the position of the future vessel
CC formation, during vasculogenesis. Promotes sinus venosus (SV)-derived
CC endothelial cells migration into the developing heart to promote
CC coronary blood vessel development. Also plays a role in various
CC processes in adults such as regulation of blood vessel formation, blood
CC pressure, heart contractility and heart failure.
CC {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:P79960,
CC ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08}.
CC -!- FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for
CC HIV-1 infection; may be involved in the development of AIDS dementia.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35414};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960}. Note=After
CC exposure to apelin (APLN) or apelin receptor early endogenous ligand
CC (APELA), internalized from the cell surface into an endosomal recycling
CC compartment, from where it is recycled to the cell membrane.
CC {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:Q9JHG3}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF100206; AAC72404.1; -; Genomic_DNA.
DR RefSeq; NP_001040591.1; NM_001047126.1.
DR AlphaFoldDB; O97666; -.
DR SMR; O97666; -.
DR STRING; 9544.ENSMMUP00000013928; -.
DR GeneID; 706823; -.
DR KEGG; mcc:706823; -.
DR CTD; 187; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; O97666; -.
DR OMA; TVMLTCY; -.
DR OrthoDB; 788659at2759; -.
DR TreeFam; TF330024; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0060182; F:apelin receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001568; P:blood vessel development; IBA:GO_Central.
DR GO; GO:0060976; P:coronary vasculature development; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0043951; P:negative regulation of cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISS:UniProtKB.
DR GO; GO:1904325; P:positive regulation of inhibitory G protein-coupled receptor phosphorylation; ISS:UniProtKB.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR InterPro; IPR003904; Apelin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24228:SF31; PTHR24228:SF31; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01416; APJRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Developmental protein; G-protein coupled receptor;
KW Gastrulation; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..380
FT /note="Apelin receptor"
FT /id="PRO_0000069174"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..380
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 342..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 380 AA; 42606 MW; E84F03E31FABF7ED CRC64;
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF SCKLSSYLIF VNMYASVFCL
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVFRTT GDLENTTKVQ
CYMDYSMVAT VSSDWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNV FPYCTCISYV
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK
GGEQMHEKSI PYSQETLVVD
