IHO1_HUMAN
ID IHO1_HUMAN Reviewed; 594 AA.
AC Q8IYA8; C9JJL0; Q05DG9; Q96LP7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Interactor of HORMAD1 protein 1 {ECO:0000303|PubMed:27723721};
DE AltName: Full=Cancer/testis antigen 74;
DE Short=CT74;
DE AltName: Full=Coiled-coil domain-containing protein 36 {ECO:0000312|HGNC:HGNC:27945};
GN Name=IHO1 {ECO:0000303|PubMed:27723721, ECO:0000312|HGNC:HGNC:27945};
GN Synonyms=CCDC36 {ECO:0000312|HGNC:HGNC:27945};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-408 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP INTERACTION WITH HORMAD1.
RX PubMed=27723721; DOI=10.1038/ncb3417;
RA Stanzione M., Baumann M., Papanikos F., Dereli I., Lange J., Ramlal A.,
RA Traenkner D., Shibuya H., de Massy B., Watanabe Y., Jasin M., Keeney S.,
RA Toth A.;
RT "Meiotic DNA break formation requires the unsynapsed chromosome axis-
RT binding protein IHO1 (CCDC36) in mice.";
RL Nat. Cell Biol. 18:1208-1220(2016).
RN [5]
RP INTERACTION WITH REC114.
RX PubMed=31704776; DOI=10.1136/jmedgenet-2019-106379;
RA Wang W., Dong J., Chen B., Du J., Kuang Y., Sun X., Fu J., Li B., Mu J.,
RA Zhang Z., Zhou Z., Lin Z., Wu L., Yan Z., Mao X., Li Q., He L., Wang L.,
RA Sang Q.;
RT "Homozygous mutations in REC114 cause female infertility characterised by
RT multiple pronuclei formation and early embryonic arrest.";
RL J. Med. Genet. 57:187-194(2020).
CC -!- FUNCTION: Required for DNA double-strand breaks (DSBs) formation in
CC unsynapsed regions during meiotic recombination. Probably acts by
CC forming a complex with MEI4 and REC114, which activates DSBs formation
CC in unsynapsed regions, an essential step to ensure completion of
CC synapsis. Not required for HORMAD1 functions in pairing-independent
CC synaptonemal complex formation, ATR recruitment to unsynapsed axes,
CC meiotic silencing of unsynapsed chromatin (MSUC) or meiotic
CC surveillance. {ECO:0000250|UniProtKB:Q6PDM4}.
CC -!- SUBUNIT: Interacts with HORMAD1 (PubMed:27723721). Interacts with
CC REC114 (PubMed:31704776). Part of the MCD recombinosome complex, at
CC least composed of IHO1, REC114 and MEI4 (By similarity). Interacts with
CC ANKRD31 (By similarity). {ECO:0000250|UniProtKB:Q6PDM4,
CC ECO:0000269|PubMed:27723721, ECO:0000269|PubMed:31704776}.
CC -!- INTERACTION:
CC Q8IYA8; Q9NYB9: ABI2; NbExp=6; IntAct=EBI-8638439, EBI-743598;
CC Q8IYA8; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-8638439, EBI-11096309;
CC Q8IYA8; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-8638439, EBI-742038;
CC Q8IYA8; P58397-3: ADAMTS12; NbExp=3; IntAct=EBI-8638439, EBI-12048761;
CC Q8IYA8; P29972: AQP1; NbExp=3; IntAct=EBI-8638439, EBI-745213;
CC Q8IYA8; Q86V38: ATN1; NbExp=3; IntAct=EBI-8638439, EBI-11954292;
CC Q8IYA8; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-8638439, EBI-12006120;
CC Q8IYA8; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-8638439, EBI-8643161;
CC Q8IYA8; Q9H257: CARD9; NbExp=3; IntAct=EBI-8638439, EBI-751319;
CC Q8IYA8; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-8638439, EBI-11530605;
CC Q8IYA8; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-8638439, EBI-744556;
CC Q8IYA8; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-8638439, EBI-10961624;
CC Q8IYA8; Q9UJX2: CDC23; NbExp=6; IntAct=EBI-8638439, EBI-396137;
CC Q8IYA8; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-8638439, EBI-749051;
CC Q8IYA8; P10606: COX5B; NbExp=4; IntAct=EBI-8638439, EBI-1053725;
CC Q8IYA8; P63167: DYNLL1; NbExp=6; IntAct=EBI-8638439, EBI-349105;
CC Q8IYA8; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-8638439, EBI-742371;
CC Q8IYA8; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-8638439, EBI-743105;
CC Q8IYA8; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-8638439, EBI-742102;
CC Q8IYA8; Q86V42: FAM124A; NbExp=3; IntAct=EBI-8638439, EBI-744506;
CC Q8IYA8; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-8638439, EBI-11986315;
CC Q8IYA8; Q9NW38: FANCL; NbExp=3; IntAct=EBI-8638439, EBI-2339898;
CC Q8IYA8; P48023: FASLG; NbExp=3; IntAct=EBI-8638439, EBI-495538;
CC Q8IYA8; Q13643: FHL3; NbExp=4; IntAct=EBI-8638439, EBI-741101;
CC Q8IYA8; O75344: FKBP6; NbExp=8; IntAct=EBI-8638439, EBI-744771;
CC Q8IYA8; P55040: GEM; NbExp=3; IntAct=EBI-8638439, EBI-744104;
CC Q8IYA8; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-8638439, EBI-748515;
CC Q8IYA8; P13807: GYS1; NbExp=6; IntAct=EBI-8638439, EBI-740553;
CC Q8IYA8; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-8638439, EBI-14103818;
CC Q8IYA8; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-8638439, EBI-5460660;
CC Q8IYA8; Q8NA54: IQUB; NbExp=4; IntAct=EBI-8638439, EBI-10220600;
CC Q8IYA8; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-8638439, EBI-2556193;
CC Q8IYA8; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-8638439, EBI-8472129;
CC Q8IYA8; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-8638439, EBI-14069005;
CC Q8IYA8; Q6P597: KLC3; NbExp=3; IntAct=EBI-8638439, EBI-1643885;
CC Q8IYA8; Q9NVR0: KLHL11; NbExp=3; IntAct=EBI-8638439, EBI-2691832;
CC Q8IYA8; Q92876: KLK6; NbExp=3; IntAct=EBI-8638439, EBI-2432309;
CC Q8IYA8; P25791: LMO2; NbExp=3; IntAct=EBI-8638439, EBI-739696;
CC Q8IYA8; P25791-3: LMO2; NbExp=3; IntAct=EBI-8638439, EBI-11959475;
CC Q8IYA8; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-8638439, EBI-739832;
CC Q8IYA8; Q17RB8: LONRF1; NbExp=6; IntAct=EBI-8638439, EBI-2341787;
CC Q8IYA8; O15481: MAGEB4; NbExp=3; IntAct=EBI-8638439, EBI-751857;
CC Q8IYA8; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-8638439, EBI-746778;
CC Q8IYA8; P45984: MAPK9; NbExp=3; IntAct=EBI-8638439, EBI-713568;
CC Q8IYA8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-8638439, EBI-10172526;
CC Q8IYA8; Q96HT8: MRFAP1L1; NbExp=7; IntAct=EBI-8638439, EBI-748896;
CC Q8IYA8; Q9HC98: NEK6; NbExp=3; IntAct=EBI-8638439, EBI-740364;
CC Q8IYA8; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-8638439, EBI-11750983;
CC Q8IYA8; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-8638439, EBI-10271199;
CC Q8IYA8; Q9NPG2: NGB; NbExp=6; IntAct=EBI-8638439, EBI-10311409;
CC Q8IYA8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8638439, EBI-79165;
CC Q8IYA8; O15160: POLR1C; NbExp=3; IntAct=EBI-8638439, EBI-1055079;
CC Q8IYA8; O43741: PRKAB2; NbExp=6; IntAct=EBI-8638439, EBI-1053424;
CC Q8IYA8; Q9NV39: PRR34; NbExp=3; IntAct=EBI-8638439, EBI-11959565;
CC Q8IYA8; Q9UJ41-4: RABGEF1; NbExp=3; IntAct=EBI-8638439, EBI-14093916;
CC Q8IYA8; O75771: RAD51D; NbExp=6; IntAct=EBI-8638439, EBI-1055693;
CC Q8IYA8; O94955: RHOBTB3; NbExp=3; IntAct=EBI-8638439, EBI-2367123;
CC Q8IYA8; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-8638439, EBI-11984663;
CC Q8IYA8; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-8638439, EBI-10224192;
CC Q8IYA8; O00560: SDCBP; NbExp=3; IntAct=EBI-8638439, EBI-727004;
CC Q8IYA8; O00506: STK25; NbExp=3; IntAct=EBI-8638439, EBI-618295;
CC Q8IYA8; Q14142: TRIM14; NbExp=3; IntAct=EBI-8638439, EBI-2820256;
CC Q8IYA8; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-8638439, EBI-5235829;
CC Q8IYA8; Q6DKK2: TTC19; NbExp=6; IntAct=EBI-8638439, EBI-948354;
CC Q8IYA8; O75604: USP2; NbExp=3; IntAct=EBI-8638439, EBI-743272;
CC Q8IYA8; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-8638439, EBI-14096082;
CC Q8IYA8; Q9Y2K6: USP20; NbExp=3; IntAct=EBI-8638439, EBI-2511991;
CC Q8IYA8; Q9BRR0: ZKSCAN3; NbExp=3; IntAct=EBI-8638439, EBI-1965777;
CC Q8IYA8; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-8638439, EBI-740727;
CC Q8IYA8; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-8638439, EBI-16429014;
CC Q8IYA8; Q9H614; NbExp=3; IntAct=EBI-8638439, EBI-10249899;
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PDM4}.
CC Note=Specifically localizes to unsynapsed chromosomal regions during
CC meiosis. {ECO:0000250|UniProtKB:Q6PDM4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IYA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYA8-2; Sequence=VSP_027987, VSP_027988;
CC Name=3;
CC IsoId=Q8IYA8-3; Sequence=VSP_027989, VSP_027990;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36202.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC121247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015057; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC036202; AAH36202.1; ALT_INIT; mRNA.
DR EMBL; AK058049; BAB71640.1; -; mRNA.
DR CCDS; CCDS33755.2; -. [Q8IYA8-1]
DR RefSeq; NP_001128669.1; NM_001135197.1. [Q8IYA8-1]
DR RefSeq; NP_835467.2; NM_178173.3. [Q8IYA8-1]
DR RefSeq; XP_006713187.1; XM_006713124.3. [Q8IYA8-1]
DR RefSeq; XP_011531974.1; XM_011533672.2. [Q8IYA8-1]
DR RefSeq; XP_011531975.1; XM_011533673.2. [Q8IYA8-1]
DR AlphaFoldDB; Q8IYA8; -.
DR SMR; Q8IYA8; -.
DR BioGRID; 130947; 99.
DR IntAct; Q8IYA8; 83.
DR MINT; Q8IYA8; -.
DR STRING; 9606.ENSP00000391788; -.
DR GlyGen; Q8IYA8; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8IYA8; -.
DR PhosphoSitePlus; Q8IYA8; -.
DR BioMuta; CCDC36; -.
DR DMDM; 313104087; -.
DR MassIVE; Q8IYA8; -.
DR PaxDb; Q8IYA8; -.
DR PeptideAtlas; Q8IYA8; -.
DR PRIDE; Q8IYA8; -.
DR ProteomicsDB; 71136; -. [Q8IYA8-2]
DR Antibodypedia; 48985; 194 antibodies from 22 providers.
DR DNASU; 339834; -.
DR Ensembl; ENST00000296449.9; ENSP00000296449.5; ENSG00000173421.17. [Q8IYA8-1]
DR Ensembl; ENST00000366429.2; ENSP00000403700.1; ENSG00000173421.17. [Q8IYA8-3]
DR Ensembl; ENST00000438782.5; ENSP00000391788.1; ENSG00000173421.17. [Q8IYA8-1]
DR Ensembl; ENST00000452691.7; ENSP00000407837.2; ENSG00000173421.17. [Q8IYA8-1]
DR GeneID; 339834; -.
DR KEGG; hsa:339834; -.
DR MANE-Select; ENST00000452691.7; ENSP00000407837.2; NM_001135197.2; NP_001128669.1.
DR UCSC; uc003cwk.3; human. [Q8IYA8-1]
DR CTD; 339834; -.
DR DisGeNET; 339834; -.
DR GeneCards; IHO1; -.
DR HGNC; HGNC:27945; IHO1.
DR HPA; ENSG00000173421; Tissue enriched (testis).
DR MIM; 619190; gene.
DR neXtProt; NX_Q8IYA8; -.
DR OpenTargets; ENSG00000173421; -.
DR VEuPathDB; HostDB:ENSG00000173421; -.
DR eggNOG; ENOG502S0PR; Eukaryota.
DR GeneTree; ENSGT00390000012418; -.
DR HOGENOM; CLU_034910_0_0_1; -.
DR InParanoid; Q8IYA8; -.
DR OMA; PGEFGVW; -.
DR OrthoDB; 974040at2759; -.
DR PhylomeDB; Q8IYA8; -.
DR TreeFam; TF337135; -.
DR PathwayCommons; Q8IYA8; -.
DR SignaLink; Q8IYA8; -.
DR BioGRID-ORCS; 339834; 37 hits in 1075 CRISPR screens.
DR ChiTaRS; CCDC36; human.
DR GenomeRNAi; 339834; -.
DR Pharos; Q8IYA8; Tbio.
DR PRO; PR:Q8IYA8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8IYA8; protein.
DR Bgee; ENSG00000173421; Expressed in left testis and 104 other tissues.
DR Genevisible; Q8IYA8; HS.
DR GO; GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR031529; IHO1.
DR PANTHER; PTHR35662; PTHR35662; 1.
DR Pfam; PF15771; IHO1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Coiled coil; Differentiation;
KW DNA recombination; Meiosis; Oogenesis; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..594
FT /note="Interactor of HORMAD1 protein 1"
FT /id="PRO_0000302875"
FT REGION 434..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 109..135
FT /evidence="ECO:0000255"
FT COILED 165..189
FT /evidence="ECO:0000255"
FT COILED 219..245
FT /evidence="ECO:0000255"
FT MOD_RES 588
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PDM4"
FT MOD_RES 589
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PDM4"
FT VAR_SEQ 1..19
FT /note="MNFNVWNIKEMLSIPSGSG -> MARVDAKAKEAPRASEGCQHAVTSQR
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027987"
FT VAR_SEQ 91..117
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027988"
FT VAR_SEQ 133..203
FT /note="ETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQA
FT QNDLVFEAVQDKGNMEQAI -> CRRLWKSLRTISVQEANLFWILWRLWPRHVSASCLR
FT YQQRALVNDEHELSDPSLVSSGEVPHRVSDERMGI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027989"
FT VAR_SEQ 204..594
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027990"
FT VARIANT 440
FT /note="D -> E (in dbSNP:rs13068038)"
FT /id="VAR_035002"
SQ SEQUENCE 594 AA; 66343 MW; 36E6C739E55DF4B1 CRC64;
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE NSETLSAPLD
FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG GLFPPPLSVG KSKGLLEQFE
EKKKRAKDKC DSETLYNFVS NVRESILRLQ TSVEKSEDHL SSRSQSILDS LETVAKTLQE
TIQAQNDLVF EAVQDKGNME QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ
LCEQLGQLNV PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD KVVQTNCKNW
AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF STSIKNACQK YQAQSMFLCD
PREHLVIKQK DGTVEMRGKD KKQQPRKAHR AHRGRLIASK QKQIPIQTCK FNSKYQSPQP
AISVPQSPFL GQQEPRAQPL HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS
SQDNWLLSSS SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF
