ID   IIGP5_BOVIN             Reviewed;         465 AA.
AC   Q32KW9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Interferon-inducible GTPase 5;
DE            EC=3.6.5.-;
DE   AltName: Full=Immunity-related GTPase cinema 1;
GN   Name=IRGC; Synonyms=IIGP5, IRGC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000255|PROSITE-ProRule:PRU01053,
CC       ECO:0000305}.
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DR   EMBL; BC109879; AAI09880.1; -; mRNA.
DR   RefSeq; NP_001069614.1; NM_001076146.2.
DR   AlphaFoldDB; Q32KW9; -.
DR   SMR; Q32KW9; -.
DR   STRING; 9913.ENSBTAP00000018295; -.
DR   PaxDb; Q32KW9; -.
DR   GeneID; 539080; -.
DR   KEGG; bta:539080; -.
DR   CTD; 56269; -.
DR   eggNOG; ENOG502QS9R; Eukaryota.
DR   InParanoid; Q32KW9; -.
DR   OrthoDB; 688334at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:RHEA.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR007743; Immunity-related_GTPase-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF05049; IIGP; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51716; G_IRG; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..465
FT                   /note="Interferon-inducible GTPase 5"
FT                   /id="PRO_0000285264"
FT   DOMAIN          53..235
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01053"
FT   REGION          405..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         62..69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         87..91
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         169..171
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         216..218
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYF9"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYF9"
SQ   SEQUENCE   465 AA;  50698 MW;  5DECDBA6DA1F7C0C CRC64;
     MATSKLPAVS GEEETTILMA KEELEALRTA FESGDIPQAA SRLRELLASS DCTRLEVGVT
     GESGAGKSSL INALRGLGAE DPDAALTGVV ETTIEPSPYP HPQFPDVTLW DLPGAGSPGC
     SADKYLKQVD FGRYDFFLLV SPRRCGAVET RLASEILRQG KKFYFVRTKV DEDLAATRMQ
     RPSGFSEGAV LHEIREHCVE RLRGAGVHDP RVFLVSNLSP ARYDFPLLMS TWERDLPAHR
     RHAGLLSLPD ISLEALQEKK DMLQEQVLKT ALVSGVIQAL PVPGLAAAYD DALLIRSLRG
     YHRSFGLDDD SLAKLAEQVG KQAGDLRSVI RSPLANEVSP ETVLRLYSQS SDGAMRVARA
     FEKGIPVFGT LVAGGISFGT VYTMLQGCLN EMAEDAQRVR IKALEEEEDT QPDVSLEAAG
     DNGVEKRGSG EGSMEEAPLS TRRKLGLLLK YILDSWKKRD LAEDK