IIGP5_HUMAN
ID IIGP5_HUMAN Reviewed; 463 AA.
AC Q6NXR0; Q05BR8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Interferon-inducible GTPase 5;
DE EC=3.6.5.-;
DE AltName: Full=Immunity-related GTPase cinema 1;
GN Name=IRGC; Synonyms=IIGP5, IRGC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-135.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC -!- INTERACTION:
CC Q6NXR0; O95273: CCNDBP1; NbExp=3; IntAct=EBI-12021374, EBI-748961;
CC Q6NXR0; P61978-2: HNRNPK; NbExp=3; IntAct=EBI-12021374, EBI-7060731;
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000255|PROSITE-ProRule:PRU01053,
CC ECO:0000305}.
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DR EMBL; AC005622; AAC34467.1; -; Genomic_DNA.
DR EMBL; BC033853; AAH33853.1; -; mRNA.
DR EMBL; BC066939; AAH66939.1; -; mRNA.
DR CCDS; CCDS12629.1; -.
DR RefSeq; NP_062558.1; NM_019612.3.
DR RefSeq; XP_006723346.1; XM_006723283.3.
DR RefSeq; XP_011525420.1; XM_011527118.2.
DR AlphaFoldDB; Q6NXR0; -.
DR SMR; Q6NXR0; -.
DR BioGRID; 121129; 19.
DR IntAct; Q6NXR0; 17.
DR STRING; 9606.ENSP00000244314; -.
DR DrugBank; DB03814; 2-(N-morpholino)ethanesulfonic acid.
DR DrugBank; DB04315; Guanosine-5'-Diphosphate.
DR iPTMnet; Q6NXR0; -.
DR PhosphoSitePlus; Q6NXR0; -.
DR BioMuta; IRGC; -.
DR DMDM; 74736988; -.
DR jPOST; Q6NXR0; -.
DR MassIVE; Q6NXR0; -.
DR MaxQB; Q6NXR0; -.
DR PaxDb; Q6NXR0; -.
DR PeptideAtlas; Q6NXR0; -.
DR PRIDE; Q6NXR0; -.
DR ProteomicsDB; 66764; -.
DR Antibodypedia; 31099; 197 antibodies from 31 providers.
DR DNASU; 56269; -.
DR Ensembl; ENST00000244314.6; ENSP00000244314.5; ENSG00000124449.7.
DR GeneID; 56269; -.
DR KEGG; hsa:56269; -.
DR MANE-Select; ENST00000244314.6; ENSP00000244314.5; NM_019612.4; NP_062558.1.
DR UCSC; uc002oxh.4; human.
DR CTD; 56269; -.
DR DisGeNET; 56269; -.
DR GeneCards; IRGC; -.
DR HGNC; HGNC:28835; IRGC.
DR HPA; ENSG00000124449; Tissue enriched (testis).
DR neXtProt; NX_Q6NXR0; -.
DR OpenTargets; ENSG00000124449; -.
DR PharmGKB; PA142671651; -.
DR VEuPathDB; HostDB:ENSG00000124449; -.
DR eggNOG; ENOG502QS9R; Eukaryota.
DR GeneTree; ENSGT00950000183007; -.
DR HOGENOM; CLU_015342_2_0_1; -.
DR InParanoid; Q6NXR0; -.
DR OMA; QEIREHC; -.
DR OrthoDB; 688334at2759; -.
DR PhylomeDB; Q6NXR0; -.
DR TreeFam; TF331897; -.
DR PathwayCommons; Q6NXR0; -.
DR SignaLink; Q6NXR0; -.
DR BioGRID-ORCS; 56269; 11 hits in 1068 CRISPR screens.
DR GeneWiki; Interferon-inducible_GTPase_5; -.
DR GenomeRNAi; 56269; -.
DR Pharos; Q6NXR0; Tbio.
DR PRO; PR:Q6NXR0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6NXR0; protein.
DR Bgee; ENSG00000124449; Expressed in left testis and 39 other tissues.
DR ExpressionAtlas; Q6NXR0; baseline and differential.
DR Genevisible; Q6NXR0; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0035458; P:cellular response to interferon-beta; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF05049; IIGP; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51716; G_IRG; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..463
FT /note="Interferon-inducible GTPase 5"
FT /id="PRO_0000285265"
FT DOMAIN 53..235
FT /note="IRG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01053"
FT REGION 404..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 62..69
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT BINDING 87..91
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT BINDING 169..171
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT BINDING 216..218
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT MOD_RES 247
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYF9"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYF9"
FT VARIANT 135
FT /note="D -> N (in dbSNP:rs11555891)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032008"
SQ SEQUENCE 463 AA; 50288 MW; 8ED3B06C512212D0 CRC64;
MATSKLPVVP GEEENTILMA KERLEALRTA FESGDLPQAA SHLQELLAST ESIRLEVGVT
GESGAGKSSL INALRGLEAE DPGAALTGVM ETTMQPSPYP HPQFPDVTLW DLPGAGSPGC
PADKYLKQVD FSRYDFFLLV SPRRCGAVET RLAAEILCQG KKFYFVRTKV DEDLAATRTQ
RPSGFREAAV LQEIRDHCAE RLREAGVADP RIFLVSNLSP ARYDFPTLVS TWEHDLPSHR
RHAGLLSLPD ISLEALQKKK AMLQEQVLKT ALVLGVIQAL PVPGLAAAYD DALLIHSLRG
YHRSFGLDDD SLAKLAEQVG KQAGDLRSVI RSPLANEVSP ETVLRLYSQS SDGAMRVARA
FERGIPVFGT LVAGGISFGA VYTMLQGCLN EMAEDAQRVR IKALEDDEPQ PEVSLEVASD
NGVEKGGSGE GGGEEAPLST CRKLGLLLKY ILDSWKKHDS EEK
