IIGP5_RAT
ID IIGP5_RAT Reviewed; 463 AA.
AC Q6AYF9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Interferon-inducible GTPase 5;
DE EC=3.6.5.-;
DE AltName: Full=Immunity-related GTPase cinema 1;
GN Name=Irgc; Synonyms=Iigp5, Irgc1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246 AND SER-303, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000255|PROSITE-ProRule:PRU01053,
CC ECO:0000305}.
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DR EMBL; BC079034; AAH79034.1; -; mRNA.
DR EMBL; BC079061; AAH79061.1; -; mRNA.
DR RefSeq; NP_001014038.1; NM_001014016.1.
DR RefSeq; XP_006228487.1; XM_006228425.3.
DR RefSeq; XP_006228488.1; XM_006228426.3.
DR RefSeq; XP_006228489.1; XM_006228427.3.
DR RefSeq; XP_008757149.1; XM_008758927.2.
DR AlphaFoldDB; Q6AYF9; -.
DR SMR; Q6AYF9; -.
DR STRING; 10116.ENSRNOP00000030295; -.
DR CarbonylDB; Q6AYF9; -.
DR iPTMnet; Q6AYF9; -.
DR PhosphoSitePlus; Q6AYF9; -.
DR PaxDb; Q6AYF9; -.
DR PRIDE; Q6AYF9; -.
DR Ensembl; ENSRNOT00000030900; ENSRNOP00000030295; ENSRNOG00000024257.
DR Ensembl; ENSRNOT00000103829; ENSRNOP00000083551; ENSRNOG00000024257.
DR Ensembl; ENSRNOT00000105042; ENSRNOP00000087872; ENSRNOG00000024257.
DR Ensembl; ENSRNOT00000115582; ENSRNOP00000090201; ENSRNOG00000024257.
DR Ensembl; ENSRNOT00000119560; ENSRNOP00000092074; ENSRNOG00000024257.
DR Ensembl; ENSRNOT00000119898; ENSRNOP00000095705; ENSRNOG00000024257.
DR GeneID; 308428; -.
DR KEGG; rno:308428; -.
DR UCSC; RGD:1311107; rat.
DR CTD; 56269; -.
DR RGD; 1311107; Irgc.
DR eggNOG; ENOG502QS9R; Eukaryota.
DR GeneTree; ENSGT00950000183007; -.
DR HOGENOM; CLU_015342_2_0_1; -.
DR InParanoid; Q6AYF9; -.
DR OMA; QEIREHC; -.
DR OrthoDB; 688334at2759; -.
DR PhylomeDB; Q6AYF9; -.
DR TreeFam; TF331897; -.
DR PRO; PR:Q6AYF9; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000024257; Expressed in testis and 3 other tissues.
DR ExpressionAtlas; Q6AYF9; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0035458; P:cellular response to interferon-beta; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF05049; IIGP; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51716; G_IRG; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..463
FT /note="Interferon-inducible GTPase 5"
FT /id="PRO_0000285267"
FT DOMAIN 52..234
FT /note="IRG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01053"
FT REGION 409..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 61..68
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 86..90
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 168..170
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 215..217
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 246
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 303
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 463 AA; 50556 MW; E1B59CDC966A2578 CRC64;
MATSRLPAVP EEETTILMAK EELEALRTAF ESGDIPQAAS RLRELLATTE TTRLEVGVTG
ESGAGKSSLI NALRGVGAED PGAALTGVVE TTMQPSPYPH PQFPDVTLWD LPGAGSPGCS
ADKYLKEVDF GRYDFFLLVS PRRCGAVETR LASEILRQGK KFYFVRTKVD EDLAATRNQR
PSGFSEAAVL QEIRDHCAER LRAAGLSDPR IFLVSNLSPN RYDFPMLVTT WEHDLPAHRR
HAGLLSLPDI SLEALQKKKD MLQEQVLKTA LVSGVIQALP VPGLAAAYDD ALLIRSLRGY
HRSFGLDDDS LAKLAEQVGK QAGDLRSVIR SPLANEVSPE TVLRLYSQSS DGAMRVARAF
ERGIPVFGTL VAGGISFGTV YTMLQGCLNE MAEDAQRVRI KALEEDETQG EVSLEAAGDN
AVEKRSSGEG TSEEAPLSTR RKLGLLLKYI LDSWKRRDLS EDK
