ID   IINMP_SCHPO             Reviewed;         615 AA.
AC   O13681;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Integral inner nuclear membrane protein ima1;
GN   Name=IMA1; ORFNames=SPCC737.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=18692466; DOI=10.1016/j.cell.2008.06.022;
RA   King M.C., Drivas T.G., Blobel G.;
RT   "A network of nuclear envelope membrane proteins linking centromeres to
RT   microtubules.";
RL   Cell 134:427-438(2008).
CC   -!- FUNCTION: Inner nuclear membrane protein that specifically binds to
CC       heterochromatic regions and promotes the tethering of centromeric DNA
CC       to the SUN-KASH complex. Couples centromeres to the nuclear envelope,
CC       thus contributing to their association with the microtubule organizing
CC       center attachment site and to the positioning of the nucleus at the
CC       cell center by microtubules. {ECO:0000269|PubMed:18692466}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000269|PubMed:18692466}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:18692466}.
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DR   EMBL; CU329672; CAA20860.1; -; Genomic_DNA.
DR   PIR; T41576; T41576.
DR   RefSeq; NP_588365.1; NM_001023356.2.
DR   AlphaFoldDB; O13681; -.
DR   BioGRID; 275756; 167.
DR   STRING; 4896.SPCC737.03c.1; -.
DR   iPTMnet; O13681; -.
DR   MaxQB; O13681; -.
DR   PaxDb; O13681; -.
DR   PRIDE; O13681; -.
DR   EnsemblFungi; SPCC737.03c.1; SPCC737.03c.1:pep; SPCC737.03c.
DR   GeneID; 2539185; -.
DR   KEGG; spo:SPCC737.03c; -.
DR   PomBase; SPCC737.03c; -.
DR   VEuPathDB; FungiDB:SPCC737.03c; -.
DR   eggNOG; KOG4623; Eukaryota.
DR   HOGENOM; CLU_444202_0_0_1; -.
DR   InParanoid; O13681; -.
DR   OMA; ETSAPNF; -.
DR   PRO; PR:O13681; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0034506; C:chromosome, centromeric core domain; IDA:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0034992; C:microtubule organizing center attachment site; IDA:PomBase.
DR   GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR   GO; GO:0005635; C:nuclear envelope; IDA:PomBase.
DR   GO; GO:0005637; C:nuclear inner membrane; IDA:PomBase.
DR   GO; GO:0031965; C:nuclear membrane; IDA:PomBase.
DR   GO; GO:0071765; P:nuclear inner membrane organization; IGI:PomBase.
DR   InterPro; IPR042321; Ima1.
DR   InterPro; IPR018617; Ima1_N.
DR   PANTHER; PTHR28538; PTHR28538; 1.
DR   Pfam; PF09779; Ima1_N; 1.
PE   4: Predicted;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..615
FT                   /note="Integral inner nuclear membrane protein ima1"
FT                   /id="PRO_0000116805"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        563..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        586..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          357..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   615 AA;  70434 MW;  D5CA85894410064E CRC64;
     MESSRLFTLG LGNSDDGLKS TFGDKTVTCF YCNKKKEKIR DGTSTWTCSI CEATNHIDEK
     GDILDYRPPT PTQDKGVGPF YAIRDFPSSS SFQSPFCEKC QMNQLIVNRM LADYLPDSSH
     PDYQAYEKAL PEYKKSIEEK FPIVCSECYD SVQDQLDAND YEAKNQVLGY WLQKSKEQLN
     AKVPHHYPKA SFVLWLLRGF GFSFFYLQSI VWHLYHSMII SLLPDGIRNL FLKAISYFLL
     DGSSSKIFYF NWLGFFVVFW NPYWYKMMDN PSWELFGRDQ YIQCQALYLI IRLTCLYLLS
     CYESEILNLS SDTNLESDFL LRQIHAAFFF VTICFTWISI SCLKPSPPPE VHLTGEILKP
     RKKRQESTSS VHRIGKESSD RKDGISGQNK LQQFATISIL NNTNATSHLG NQSVRERAPE
     ESPMTFLQKK MAALPTSSPV RPMLKPTLQL QNSPLSKLVP QEVGNKVNDS IHTTSNQPSK
     FSLNPSISLK GDNVIEKNLP FSVSTLKSTA KKDTGKAGDG QNREIQNEPV SLESHFSKSL
     ALQNDPTEVI QVKNVLHRNR RNAKLLIAFT ILFLVGLICG WRLNRFTMFI YYLCILVLAT
     YYVMKHNFYP LRKVA