ID   IKA1B_XENLA             Reviewed;         316 AA.
AC   A0FGR0; A1L3J3;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=PAK4-inhibitor inka2 {ECO:0000305};
DE   AltName: Full=Induced in neural crest by AP2-alpha protein B {ECO:0000303|PubMed:17314132};
DE            Short=IncaB {ECO:0000303|PubMed:17314132};
GN   Name=inka1-b {ECO:0000305};
GN   Synonyms=fam212a-b, inca-b, incab {ECO:0000303|PubMed:17314132},
GN   inka2 {ECO:0000250|UniProtKB:Q9NTI7};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000312|EMBL:ABJ97521.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17314132; DOI=10.1242/dev.02813;
RA   Luo T., Xu Y., Hoffman T.L., Zhang T., Schilling T., Sargent T.D.;
RT   "Inca: a novel p21-activated kinase-associated protein required for cranial
RT   neural crest development.";
RL   Development 134:1279-1289(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of the serine/threonine-protein kinase pak4/pak5.
CC       Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the
CC       protein kinase activity. {ECO:0000250|UniProtKB:Q96EL1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NTI7}.
CC   -!- DOMAIN: The Inka box (also named iBox or inca box) binds and inhibits
CC       PAK4 by binding a substrate-like manner.
CC       {ECO:0000250|UniProtKB:Q96EL1}.
CC   -!- SIMILARITY: Belongs to the INKA family. {ECO:0000305}.
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DR   EMBL; DQ993180; ABJ97521.1; -; mRNA.
DR   EMBL; BC130131; AAI30132.1; -; mRNA.
DR   EMBL; BC169645; AAI69645.1; -; mRNA.
DR   EMBL; BC169647; AAI69647.1; -; mRNA.
DR   RefSeq; NP_001090198.1; NM_001096729.2.
DR   AlphaFoldDB; A0FGR0; -.
DR   GeneID; 779095; -.
DR   KEGG; xla:779095; -.
DR   CTD; 779095; -.
DR   Xenbase; XB-GENE-866067; inka1.L.
DR   OrthoDB; 1368451at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 779095; Expressed in neurula embryo and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISS:UniProtKB.
DR   InterPro; IPR029267; FAM212.
DR   InterPro; IPR039201; Inka.
DR   PANTHER; PTHR28615; PTHR28615; 1.
DR   Pfam; PF15342; FAM212; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..316
FT                   /note="PAK4-inhibitor inka2"
FT                   /id="PRO_0000438819"
FT   REGION          43..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..219
FT                   /note="Inka box"
FT                   /evidence="ECO:0000250|UniProtKB:Q96EL1"
FT   COMPBIAS        58..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  35163 MW;  4B2A39CE6287F43E CRC64;
     MHKSHLDSVA PQLRSDLQCI KASSSSLCDQ MECMLRVLQD FKRSSPPPSP DIEKPCVVPP
     RRAPRRDNRI SHRTSDLSEA DSACCMDLPS DVSPGSCGQR GLEWDSGYSE VSGGSLRGEE
     DDIVEEESET SVPTVVLRRL PTPSCQRLSS GGFLNSRQGR IRPKSTSDVC LEQWRGIGLG
     SDSQDWTGCL LSQSRSRQPL VLGDNSFADL VKQWMDLPEN VDEEGRRVRD GGRWLHKPHG
     FLISLSGNVK RRLGNMSRLR RSEQEAVKRM SCPQLGCRPL SLYYHQSLSD IAEASTNLLH
     CRSRQPIICN EGAGFL