ID   APLD1_RAT               Reviewed;         246 AA.
AC   Q6B959;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Apolipoprotein L domain-containing protein 1;
DE   AltName: Full=Vascular early response gene protein;
GN   Name=Apold1; Synonyms=Verge;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=15102925; DOI=10.1523/jneurosci.4252-03.2004;
RA   Regard J.B., Scheek S., Borbiev T., Lanahan A.A., Schneider A.,
RA   Demetriades A.-M., Hiemisch H., Barnes C.A., Verin A.D., Worley P.F.;
RT   "Verge: a novel vascular early response gene.";
RL   J. Neurosci. 24:4092-4103(2004).
CC   -!- FUNCTION: May be involved in angiogenesis. May play a role in activity-
CC       dependent changes of brain vasculature. May affect blood-brain
CC       permeability. {ECO:0000269|PubMed:15102925}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Present at low levels in brain vascular cells (at
CC       protein level). {ECO:0000269|PubMed:15102925}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels in vessels from
CC       developing heart from E12 to P12. Expression decreases markedly from
CC       P12 to P17, and is no longer detectable at P30.
CC       {ECO:0000269|PubMed:15102925}.
CC   -!- INDUCTION: In the brain, by electrical or chemical seizures (at protein
CC       level). {ECO:0000269|PubMed:15102925}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}.
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DR   EMBL; AY673969; AAT78358.1; -; mRNA.
DR   RefSeq; NP_001003403.1; NM_001003403.1.
DR   AlphaFoldDB; Q6B959; -.
DR   STRING; 10116.ENSRNOP00000010289; -.
DR   PaxDb; Q6B959; -.
DR   PRIDE; Q6B959; -.
DR   Ensembl; ENSRNOT00000010289; ENSRNOP00000010289; ENSRNOG00000007830.
DR   GeneID; 444983; -.
DR   KEGG; rno:444983; -.
DR   UCSC; RGD:1303123; rat.
DR   CTD; 81575; -.
DR   RGD; 1303123; Apold1.
DR   eggNOG; ENOG502S2T4; Eukaryota.
DR   GeneTree; ENSGT01030000234599; -.
DR   HOGENOM; CLU_086689_0_0_1; -.
DR   InParanoid; Q6B959; -.
DR   OMA; CNSREVR; -.
DR   OrthoDB; 1299849at2759; -.
DR   PhylomeDB; Q6B959; -.
DR   TreeFam; TF334681; -.
DR   PRO; PR:Q6B959; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000007830; Expressed in heart and 18 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEP:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0042118; P:endothelial cell activation; IEP:RGD.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0045601; P:regulation of endothelial cell differentiation; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   InterPro; IPR008405; ApoL.
DR   PANTHER; PTHR14096; PTHR14096; 1.
DR   Pfam; PF05461; ApoL; 1.
PE   1: Evidence at protein level;
KW   Angiogenesis; Cell membrane; Coiled coil; Developmental protein;
KW   Differentiation; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..246
FT                   /note="Apolipoprotein L domain-containing protein 1"
FT                   /id="PRO_0000247276"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          193..220
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   246 AA;  26829 MW;  2DEBB36904B57600 CRC64;
     MEKWTAWEPQ GADALRRFQG LLLDRRGRLH CQVLRLREVA RRLERLRRRS LAANVAGSSL
     SAAGALAAIV GLSLSPVTLG ASLVASAVGL GVATAGGAVT ITSDLSLIFC NSREVRRVQE
     IAATCQDQMR ELLSCLEFFC QWQGRGDRQL LQSGRDASMA LYNSVYFIVF FGSRGFLIPR
     RAEGATKVSQ AVLKAKIQKL SESLESCTGA LDELSEQLES RVQLCTKAGR GHNLRNSPDL
     DAALFF