IKBD_HUMAN
ID IKBD_HUMAN Reviewed; 313 AA.
AC Q8NI38; Q8NI39; Q9BRG9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=NF-kappa-B inhibitor delta;
DE Short=NFKB inhibitor delta;
DE AltName: Full=I-kappa-B-delta;
DE Short=IkB-delta;
DE Short=IkappaBdelta;
DE AltName: Full=IkappaBNS;
DE AltName: Full=T-cell activation NFKB-like protein;
DE AltName: Full=TA-NFKBH;
GN Name=NFKBID; Synonyms=IKBNS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=T-cell;
RX PubMed=15177553; DOI=10.1016/j.ygeno.2003.12.019;
RA Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J.,
RA Schelter J.M., Dai H., He Y.D., Linsley P.S.;
RT "T lymphocyte activation gene identification by coregulated expression on
RT DNA microarrays.";
RL Genomics 83:989-999(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates the expression of IL-2, IL-6, and other cytokines
CC through regulation on NF-kappa-B activity. Functions in the regulation
CC of inflammatory responses. Involved in the induction of T helper 17
CC cells (Th17) differentiation upon recognition of antigen by T cell
CC antigen receptor (TCR). May also regulate TCR-induced negative
CC selection of thymocytes. {ECO:0000250|UniProtKB:Q2TB02}.
CC -!- SUBUNIT: Interacts with NFKB1, RELA and RELB; in the nucleus.
CC {ECO:0000250|UniProtKB:Q2TB02}.
CC -!- INTERACTION:
CC Q8NI38; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10271199, EBI-10173507;
CC Q8NI38; P50995: ANXA11; NbExp=3; IntAct=EBI-10271199, EBI-715243;
CC Q8NI38; Q92974: ARHGEF2; NbExp=3; IntAct=EBI-10271199, EBI-302405;
CC Q8NI38; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-10271199, EBI-745073;
CC Q8NI38; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10271199, EBI-8643161;
CC Q8NI38; Q6P1W5: C1orf94; NbExp=7; IntAct=EBI-10271199, EBI-946029;
CC Q8NI38; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-10271199, EBI-12020542;
CC Q8NI38; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10271199, EBI-10175300;
CC Q8NI38; P53672: CRYBA2; NbExp=3; IntAct=EBI-10271199, EBI-750444;
CC Q8NI38; Q99895: CTRC; NbExp=3; IntAct=EBI-10271199, EBI-10295404;
CC Q8NI38; Q6BCY4-2: CYB5R2; NbExp=3; IntAct=EBI-10271199, EBI-12102608;
CC Q8NI38; Q9UHL0: DDX25; NbExp=3; IntAct=EBI-10271199, EBI-8787165;
CC Q8NI38; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-10271199, EBI-9679045;
CC Q8NI38; Q8N9I9: DTX3; NbExp=3; IntAct=EBI-10271199, EBI-2340258;
CC Q8NI38; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-10271199, EBI-2349927;
CC Q8NI38; Q14241: ELOA; NbExp=3; IntAct=EBI-10271199, EBI-742350;
CC Q8NI38; Q92731-3: ESR2; NbExp=3; IntAct=EBI-10271199, EBI-12259414;
CC Q8NI38; Q6NZ36-4: FAAP20; NbExp=6; IntAct=EBI-10271199, EBI-12013806;
CC Q8NI38; O95990-4: FAM107A; NbExp=3; IntAct=EBI-10271199, EBI-11977223;
CC Q8NI38; O95363: FARS2; NbExp=3; IntAct=EBI-10271199, EBI-2513774;
CC Q8NI38; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-10271199, EBI-12018822;
CC Q8NI38; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-10271199, EBI-372506;
CC Q8NI38; P14136: GFAP; NbExp=3; IntAct=EBI-10271199, EBI-744302;
CC Q8NI38; O75420: GIGYF1; NbExp=3; IntAct=EBI-10271199, EBI-947774;
CC Q8NI38; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-10271199, EBI-748515;
CC Q8NI38; O95872: GPANK1; NbExp=3; IntAct=EBI-10271199, EBI-751540;
CC Q8NI38; Q13322-4: GRB10; NbExp=3; IntAct=EBI-10271199, EBI-12353035;
CC Q8NI38; P56524-2: HDAC4; NbExp=3; IntAct=EBI-10271199, EBI-11953488;
CC Q8NI38; P52597: HNRNPF; NbExp=3; IntAct=EBI-10271199, EBI-352986;
CC Q8NI38; P31943: HNRNPH1; NbExp=3; IntAct=EBI-10271199, EBI-351590;
CC Q8NI38; P49639: HOXA1; NbExp=3; IntAct=EBI-10271199, EBI-740785;
CC Q8NI38; P09067: HOXB5; NbExp=3; IntAct=EBI-10271199, EBI-3893317;
CC Q8NI38; P31273: HOXC8; NbExp=3; IntAct=EBI-10271199, EBI-1752118;
CC Q8NI38; P31274: HOXC9; NbExp=3; IntAct=EBI-10271199, EBI-1779423;
CC Q8NI38; P31249: HOXD3; NbExp=3; IntAct=EBI-10271199, EBI-3957655;
CC Q8NI38; C9JCN9: HSBP1L1; NbExp=3; IntAct=EBI-10271199, EBI-2685549;
CC Q8NI38; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-10271199, EBI-8638439;
CC Q8NI38; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-10271199, EBI-747204;
CC Q8NI38; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10271199, EBI-6509505;
CC Q8NI38; P78412: IRX6; NbExp=3; IntAct=EBI-10271199, EBI-12100506;
CC Q8NI38; J3KNH0: KICS2; NbExp=3; IntAct=EBI-10271199, EBI-17269253;
CC Q8NI38; P08727: KRT19; NbExp=3; IntAct=EBI-10271199, EBI-742756;
CC Q8NI38; O76011: KRT34; NbExp=3; IntAct=EBI-10271199, EBI-1047093;
CC Q8NI38; Q6A162: KRT40; NbExp=3; IntAct=EBI-10271199, EBI-10171697;
CC Q8NI38; O95678: KRT75; NbExp=6; IntAct=EBI-10271199, EBI-2949715;
CC Q8NI38; Q01546: KRT76; NbExp=3; IntAct=EBI-10271199, EBI-2952745;
CC Q8NI38; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10271199, EBI-11962084;
CC Q8NI38; P06239-3: LCK; NbExp=3; IntAct=EBI-10271199, EBI-13287659;
CC Q8NI38; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10271199, EBI-10274069;
CC Q8NI38; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-10271199, EBI-12039345;
CC Q8NI38; P25791-3: LMO2; NbExp=3; IntAct=EBI-10271199, EBI-11959475;
CC Q8NI38; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-10271199, EBI-11742507;
CC Q8NI38; P61968: LMO4; NbExp=3; IntAct=EBI-10271199, EBI-2798728;
CC Q8NI38; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10271199, EBI-16439278;
CC Q8NI38; Q13084: MRPL28; NbExp=3; IntAct=EBI-10271199, EBI-723426;
CC Q8NI38; Q96EL3: MRPL53; NbExp=3; IntAct=EBI-10271199, EBI-2513715;
CC Q8NI38; Q9P2K5-2: MYEF2; NbExp=3; IntAct=EBI-10271199, EBI-10318831;
CC Q8NI38; O43639: NCK2; NbExp=3; IntAct=EBI-10271199, EBI-713635;
CC Q8NI38; P17568: NDUFB7; NbExp=3; IntAct=EBI-10271199, EBI-1246238;
CC Q8NI38; Q9BSH3: NICN1; NbExp=3; IntAct=EBI-10271199, EBI-13324229;
CC Q8NI38; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-10271199, EBI-741048;
CC Q8NI38; Q86TB9: PATL1; NbExp=3; IntAct=EBI-10271199, EBI-2562092;
CC Q8NI38; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10271199, EBI-11022007;
CC Q8NI38; P26367: PAX6; NbExp=3; IntAct=EBI-10271199, EBI-747278;
CC Q8NI38; Q13835-2: PKP1; NbExp=3; IntAct=EBI-10271199, EBI-9087684;
CC Q8NI38; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-10271199, EBI-12014286;
CC Q8NI38; P01189: POMC; NbExp=3; IntAct=EBI-10271199, EBI-12219503;
CC Q8NI38; Q12837: POU4F2; NbExp=3; IntAct=EBI-10271199, EBI-17236143;
CC Q8NI38; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-10271199, EBI-11320284;
CC Q8NI38; Q9NVM4: PRMT7; NbExp=3; IntAct=EBI-10271199, EBI-3215577;
CC Q8NI38; P28062-2: PSMB8; NbExp=3; IntAct=EBI-10271199, EBI-372312;
CC Q8NI38; O75127: PTCD1; NbExp=3; IntAct=EBI-10271199, EBI-2560233;
CC Q8NI38; P47897: QARS1; NbExp=3; IntAct=EBI-10271199, EBI-347462;
CC Q8NI38; O75771: RAD51D; NbExp=3; IntAct=EBI-10271199, EBI-1055693;
CC Q8NI38; Q96PK6: RBM14; NbExp=3; IntAct=EBI-10271199, EBI-954272;
CC Q8NI38; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-10271199, EBI-740773;
CC Q8NI38; Q9BQ04: RBM4B; NbExp=3; IntAct=EBI-10271199, EBI-715531;
CC Q8NI38; P48378: RFX2; NbExp=3; IntAct=EBI-10271199, EBI-746731;
CC Q8NI38; Q06587: RING1; NbExp=3; IntAct=EBI-10271199, EBI-752313;
CC Q8NI38; Q14D33: RTP5; NbExp=3; IntAct=EBI-10271199, EBI-10217913;
CC Q8NI38; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-10271199, EBI-12001422;
CC Q8NI38; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-10271199, EBI-14067109;
CC Q8NI38; Q9UPU9-3: SAMD4A; NbExp=3; IntAct=EBI-10271199, EBI-11986417;
CC Q8NI38; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10271199, EBI-748391;
CC Q8NI38; O14796: SH2D1B; NbExp=3; IntAct=EBI-10271199, EBI-3923013;
CC Q8NI38; O95391: SLU7; NbExp=3; IntAct=EBI-10271199, EBI-750559;
CC Q8NI38; Q13485: SMAD4; NbExp=3; IntAct=EBI-10271199, EBI-347263;
CC Q8NI38; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-10271199, EBI-2872322;
CC Q8NI38; Q92966: SNAPC3; NbExp=6; IntAct=EBI-10271199, EBI-1760638;
CC Q8NI38; O60504: SORBS3; NbExp=3; IntAct=EBI-10271199, EBI-741237;
CC Q8NI38; Q4VAX2: SS18; NbExp=3; IntAct=EBI-10271199, EBI-10271195;
CC Q8NI38; Q9Y242: TCF19; NbExp=3; IntAct=EBI-10271199, EBI-7413767;
CC Q8NI38; P15884-3: TCF4; NbExp=3; IntAct=EBI-10271199, EBI-13636688;
CC Q8NI38; P56279: TCL1A; NbExp=3; IntAct=EBI-10271199, EBI-749995;
CC Q8NI38; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-10271199, EBI-750487;
CC Q8NI38; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10271199, EBI-10239812;
CC Q8NI38; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-10271199, EBI-1105213;
CC Q8NI38; Q12933: TRAF2; NbExp=3; IntAct=EBI-10271199, EBI-355744;
CC Q8NI38; Q14134: TRIM29; NbExp=3; IntAct=EBI-10271199, EBI-702370;
CC Q8NI38; Q9C026: TRIM9; NbExp=3; IntAct=EBI-10271199, EBI-720828;
CC Q8NI38; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-10271199, EBI-11059915;
CC Q8NI38; Q7Z6J9: TSEN54; NbExp=3; IntAct=EBI-10271199, EBI-2559824;
CC Q8NI38; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10271199, EBI-3918381;
CC Q8NI38; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-10271199, EBI-5457544;
CC Q8NI38; P08670: VIM; NbExp=3; IntAct=EBI-10271199, EBI-353844;
CC Q8NI38; Q05516: ZBTB16; NbExp=3; IntAct=EBI-10271199, EBI-711925;
CC Q8NI38; Q5TFG8: ZC2HC1B; NbExp=3; IntAct=EBI-10271199, EBI-12275374;
CC Q8NI38; Q15915: ZIC1; NbExp=3; IntAct=EBI-10271199, EBI-11963196;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2TB02}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NI38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NI38-2; Sequence=VSP_033144;
CC Name=3;
CC IsoId=Q8NI38-3; Sequence=VSP_033143, VSP_033145;
CC -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family. {ECO:0000305}.
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DR EMBL; AF385433; AAM43834.1; -; mRNA.
DR EMBL; AF385434; AAM43835.1; -; mRNA.
DR EMBL; BC006273; AAH06273.1; -; mRNA.
DR EMBL; BC119646; AAI19647.1; -; mRNA.
DR EMBL; BC119647; AAI19648.1; -; mRNA.
DR CCDS; CCDS42552.1; -. [Q8NI38-1]
DR RefSeq; NP_640332.1; NM_139239.2. [Q8NI38-1]
DR RefSeq; XP_011525721.1; XM_011527419.2.
DR RefSeq; XP_016882880.1; XM_017027391.1. [Q8NI38-1]
DR RefSeq; XP_016882881.1; XM_017027392.1. [Q8NI38-1]
DR RefSeq; XP_016882882.1; XM_017027393.1. [Q8NI38-1]
DR AlphaFoldDB; Q8NI38; -.
DR SMR; Q8NI38; -.
DR BioGRID; 124269; 117.
DR IntAct; Q8NI38; 114.
DR MINT; Q8NI38; -.
DR STRING; 9606.ENSP00000380109; -.
DR iPTMnet; Q8NI38; -.
DR PhosphoSitePlus; Q8NI38; -.
DR BioMuta; NFKBID; -.
DR DMDM; 74751323; -.
DR EPD; Q8NI38; -.
DR MassIVE; Q8NI38; -.
DR MaxQB; Q8NI38; -.
DR PaxDb; Q8NI38; -.
DR PeptideAtlas; Q8NI38; -.
DR PRIDE; Q8NI38; -.
DR ProteomicsDB; 73829; -. [Q8NI38-1]
DR ProteomicsDB; 73830; -. [Q8NI38-2]
DR ProteomicsDB; 73831; -. [Q8NI38-3]
DR Antibodypedia; 48023; 153 antibodies from 18 providers.
DR DNASU; 84807; -.
DR Ensembl; ENST00000396901.5; ENSP00000380109.1; ENSG00000167604.15. [Q8NI38-1]
DR Ensembl; ENST00000606253.5; ENSP00000475712.2; ENSG00000167604.15. [Q8NI38-2]
DR GeneID; 84807; -.
DR KEGG; hsa:84807; -.
DR UCSC; uc002oci.1; human. [Q8NI38-1]
DR CTD; 84807; -.
DR GeneCards; NFKBID; -.
DR HGNC; HGNC:15671; NFKBID.
DR HPA; ENSG00000167604; Tissue enhanced (bone).
DR MIM; 618887; gene.
DR neXtProt; NX_Q8NI38; -.
DR OpenTargets; ENSG00000167604; -.
DR PharmGKB; PA162397453; -.
DR VEuPathDB; HostDB:ENSG00000167604; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000153695; -.
DR HOGENOM; CLU_046801_0_0_1; -.
DR InParanoid; Q8NI38; -.
DR OMA; CSFPLGM; -.
DR OrthoDB; 964992at2759; -.
DR PhylomeDB; Q8NI38; -.
DR TreeFam; TF330224; -.
DR PathwayCommons; Q8NI38; -.
DR SignaLink; Q8NI38; -.
DR BioGRID-ORCS; 84807; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; NFKBID; human.
DR GenomeRNAi; 84807; -.
DR Pharos; Q8NI38; Tbio.
DR PRO; PR:Q8NI38; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NI38; protein.
DR Bgee; ENSG00000167604; Expressed in bone marrow cell and 103 other tissues.
DR ExpressionAtlas; Q8NI38; baseline and differential.
DR Genevisible; Q8NI38; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:2000321; P:positive regulation of T-helper 17 cell differentiation; ISS:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Inflammatory response; Nucleus;
KW Reference proteome; Repeat.
FT CHAIN 1..313
FT /note="NF-kappa-B inhibitor delta"
FT /id="PRO_0000331114"
FT REPEAT 48..83
FT /note="ANK 1"
FT REPEAT 84..113
FT /note="ANK 2"
FT REPEAT 117..146
FT /note="ANK 3"
FT REPEAT 152..201
FT /note="ANK 4"
FT REPEAT 206..236
FT /note="ANK 5"
FT REPEAT 243..276
FT /note="ANK 6"
FT VAR_SEQ 1..201
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033143"
FT VAR_SEQ 1
FT /note="M -> MWVCLRGILDSQAFWHETLRRWECLLAEMKVSRGERSHCPTQTVKKL
FT LEEQRRRQQQQPDAGGVQGQFLPPPEQPLTPSVNEAVTGHPPFPAHSETVGSGPSSLGF
FT PDWDPNTHAAYTDSPYSCPASAAENFLPPDFYPPSDPGQPCPFPQGM (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15177553"
FT /id="VSP_033144"
FT VAR_SEQ 202
FT /note="Q -> MRSCCVVQAGLQLLASSDPPSSASQSARITGVNHRTPPR (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033145"
FT VARIANT 29
FT /note="V -> A (in dbSNP:rs8113704)"
FT /id="VAR_042737"
SQ SEQUENCE 313 AA; 33481 MW; B986234830428320 CRC64;
MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD TLLHLFAARG
LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI VEDLLNLGAE PNAADHQGRS
VLHVAATYGL PGVLLAVLNS GVQVDLEARD FEGLTPLHTA ILALNVAMRP SDLCPRVLST
QARDRLDCVH MLLQMGANHT SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM
KAHGNTALHM AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
LKRSRVAPPG LSS
