ID   IKBH1_MDBVW             Reviewed;         192 AA.
AC   Q5I144;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   23-FEB-2022, entry version 53.
DE   RecName: Full=I-Kappa-B like protein H1;
GN   Name=H4;
OS   Microplitis demolitor bracovirus (isolate Webb) (MdBV).
OC   Viruses; Polydnaviridae; Bracovirus.
OX   NCBI_TaxID=654919;
OH   NCBI_TaxID=69319; Microplitis demolitor.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16380146; DOI=10.1016/j.virol.2005.11.010;
RA   Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E.,
RA   Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S.,
RA   Thoetkiattikul H., Turnbull M.W., Witherell R.A.;
RT   "Polydnavirus genomes reflect their dual roles as mutualists and
RT   pathogens.";
RL   Virology 347:160-174(2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=16061795; DOI=10.1073/pnas.0505240102;
RA   Thoetkiattikul H., Beck M.H., Strand M.R.;
RT   "Inhibitor kappaB-like proteins from a polydnavirus inhibit NF-kappaB
RT   activation and suppress the insect immune response.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11426-11431(2005).
CC   -!- FUNCTION: Suppresses the host immune response through NF-kappa-B
CC       inactivation. Possesses ankyrin repeat domains required for NF-kappa-B
CC       binding but lacks the regulatory regions required for dissociation from
CC       NF-kappa-B and degradation. Therefore, prevents host NF-kappa-B release
CC       and subsequent activation. {ECO:0000269|PubMed:16061795}.
CC   -!- SIMILARITY: Belongs to the polydnaviridae I-Kappa-B-like protein
CC       family. {ECO:0000305}.
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DR   EMBL; AY875685; AAW51789.1; -; Genomic_DNA.
DR   RefSeq; YP_239384.1; NC_007035.1.
DR   SMR; Q5I144; -.
DR   GeneID; 5075820; -.
DR   KEGG; vg:5075820; -.
DR   Proteomes; UP000008168; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF13857; Ank_5; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Host-virus interaction; Inhibition of host NF-kappa-B by virus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..192
FT                   /note="I-Kappa-B like protein H1"
FT                   /id="PRO_0000405365"
FT   REPEAT          94..126
FT                   /note="ANK 1"
FT   REPEAT          131..161
FT                   /note="ANK 2"
FT   REPEAT          165..192
FT                   /note="ANK 3"
SQ   SEQUENCE   192 AA;  22163 MW;  EC169E72A571CF0E CRC64;
     MMRYYIYVQY WKRFLRLVRS FHWATSNVLL FKSDFGDTFK MRDYNLYEML SARNGSGGTY
     FHEACQANSI ALLWRAAGML DESHPRILNI RDYKGAQCTH IIATSNVSCS IDMMNIVLQL
     GADINGQEGL AGLTPLHICV NKKNYALAEW LCQAPGIDVK VENFGKETPY DLACKMEDRK
     MMKIFEERSK KM