IKBL1_HUMAN
ID IKBL1_HUMAN Reviewed; 381 AA.
AC Q9UBC1; A6NL91; B4DUW1; Q14625; Q5HYU4; Q5RJ72; Q5ST96; Q5STV4; Q5STV5;
AC Q9UBX4;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=NF-kappa-B inhibitor-like protein 1;
DE AltName: Full=Inhibitor of kappa B-like protein;
DE Short=I-kappa-B-like protein;
DE Short=IkappaBL;
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1;
GN Name=NFKBIL1; Synonyms=IKBL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT CYS-224.
RC TISSUE=Premonocytic leukemia;
RX PubMed=8081366; DOI=10.1093/hmg/3.5.793;
RA Albertella M.R., Campbell D.R.;
RT "Characterization of a novel gene in the human major histocompatibility
RT complex that encodes a potential new member of the I kappa B family of
RT proteins.";
RL Hum. Mol. Genet. 3:793-799(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9480751; DOI=10.1006/geno.1997.5114;
RA Shiina T., Tamiya G., Oka A., Yamagata T., Yamagata N., Kikkawa E.,
RA Goto K., Mizuki N., Watanabe K., Fukuzumi Y., Taguchi S., Sugawara C.,
RA Ono A., Chen L., Yamazaki M., Tashiro H., Ando A., Ikemura T., Kimura M.,
RA Inoko H.;
RT "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL
RT and MICA genes at the centromeric end of the HLA class I region.";
RL Genomics 47:372-382(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT CYS-224.
RX PubMed=10369924; DOI=10.1007/s002510050662;
RA Allcock R.J.N., Christiansen F.T., Price P.;
RT "The central MHC gene IKBL carries a structural polymorphism that is
RT associated with HLA-A3,B7,DR15.";
RL Immunogenetics 49:660-665(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10202016;
RA Neville M.J., Campbell R.D.;
RT "A new member of the Ig superfamily and a V-ATPase G subunit are among the
RT predicted products of novel genes close to the TNF locus in the human
RT MHC.";
RL J. Immunol. 162:4745-4754(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.;
RT "Genome diversity in HLA: a new strategy for detection of genetic
RT polymorphisms in expressed genes within the HLA class III and class I
RT regions.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [12]
RP FUNCTION, INTERACTION WITH CACTIN, AND SUBCELLULAR LOCATION.
RX PubMed=20829348; DOI=10.1074/jbc.m110.139113;
RA Atzei P., Gargan S., Curran N., Moynagh P.N.;
RT "Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and
RT inhibits NF-kappaB and interferon-regulatory factor signaling pathways.";
RL J. Biol. Chem. 285:36804-36817(2010).
RN [13]
RP DISEASE.
RX PubMed=12509789; DOI=10.1086/346067;
RA Okamoto K., Makino S., Yoshikawa Y., Takaki A., Nagatsuka Y., Ota M.,
RA Tamiya G., Kimura A., Bahram S., Inoko H.;
RT "Identification of I kappa BL as the second major histocompatibility
RT complex-linked susceptibility locus for rheumatoid arthritis.";
RL Am. J. Hum. Genet. 72:303-312(2003).
CC -!- FUNCTION: Involved in the regulation of innate immune response. Acts as
CC negative regulator of Toll-like receptor and interferon-regulatory
CC factor (IRF) signaling pathways. Contributes to the negative regulation
CC of transcriptional activation of NF-kappa-B target genes in response to
CC endogenous proinflammatory stimuli. {ECO:0000269|PubMed:20829348}.
CC -!- SUBUNIT: Interacts with CACTIN (via N-terminal domain); the interaction
CC occurs in a proinflammatory-independent manner.
CC {ECO:0000269|PubMed:20829348}.
CC -!- INTERACTION:
CC Q9UBC1; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-1043728, EBI-744782;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20829348}.
CC Note=Nuclear localization with a speckled expression pattern in some
CC cells. Colocalizes with CACTIN in the nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UBC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UBC1-2; Sequence=VSP_041075;
CC Name=3;
CC IsoId=Q9UBC1-3; Sequence=VSP_046261;
CC -!- TISSUE SPECIFICITY: Detected in different cell types including
CC monocytes, T-cells, B-cells and hepatocytes.
CC -!- POLYMORPHISM: Arg-224 is found in the MHC 7.1 haplotype (HLA-
CC A3,B7,DR15) population. {ECO:0000269|PubMed:10369924,
CC ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334}.
CC -!- DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory
CC disease with autoimmune features and a complex genetic component. It
CC primarily affects the joints and is characterized by inflammatory
CC changes in the synovial membranes and articular structures, widespread
CC fibrinoid degeneration of the collagen fibers in mesenchymal tissues,
CC and by atrophy and rarefaction of bony structures.
CC {ECO:0000305|PubMed:12509789}. Note=Disease susceptibility is
CC associated with variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG62473.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; X77909; CAA54867.1; -; mRNA.
DR EMBL; AB000876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB000882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF097419; AAD38108.1; -; mRNA.
DR EMBL; AF097420; AAD38109.1; -; mRNA.
DR EMBL; AF097421; AAD38110.1; -; mRNA.
DR EMBL; AF097422; AAD38111.1; -; mRNA.
DR EMBL; AF097423; AAD38112.1; -; mRNA.
DR EMBL; AF097424; AAD38113.1; -; mRNA.
DR EMBL; AF097425; AAD38114.1; -; mRNA.
DR EMBL; AF097426; AAD38115.1; -; mRNA.
DR EMBL; AF097427; AAD38116.1; -; mRNA.
DR EMBL; AF097428; AAD38117.1; -; mRNA.
DR EMBL; AF097429; AAD38118.1; -; mRNA.
DR EMBL; Y14768; CAA75072.1; -; Genomic_DNA.
DR EMBL; AK300818; BAG62473.1; ALT_SEQ; mRNA.
DR EMBL; BA000025; BAB63398.1; -; Genomic_DNA.
DR EMBL; AB088115; BAC54951.1; -; Genomic_DNA.
DR EMBL; AC004181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX001040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR942185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03417.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03418.1; -; Genomic_DNA.
DR EMBL; BC143671; AAI43672.1; -; mRNA.
DR CCDS; CCDS4700.1; -. [Q9UBC1-1]
DR CCDS; CCDS47399.1; -. [Q9UBC1-3]
DR CCDS; CCDS47400.1; -. [Q9UBC1-2]
DR PIR; S60561; S60561.
DR RefSeq; NP_001138433.1; NM_001144961.1.
DR RefSeq; NP_001138434.1; NM_001144962.1.
DR RefSeq; NP_001138435.1; NM_001144963.1.
DR RefSeq; NP_004998.3; NM_005007.3.
DR AlphaFoldDB; Q9UBC1; -.
DR SMR; Q9UBC1; -.
DR BioGRID; 110862; 95.
DR IntAct; Q9UBC1; 24.
DR STRING; 9606.ENSP00000365318; -.
DR iPTMnet; Q9UBC1; -.
DR PhosphoSitePlus; Q9UBC1; -.
DR BioMuta; NFKBIL1; -.
DR DMDM; 44888077; -.
DR EPD; Q9UBC1; -.
DR jPOST; Q9UBC1; -.
DR MassIVE; Q9UBC1; -.
DR MaxQB; Q9UBC1; -.
DR PaxDb; Q9UBC1; -.
DR PeptideAtlas; Q9UBC1; -.
DR PRIDE; Q9UBC1; -.
DR ProteomicsDB; 63900; -.
DR ProteomicsDB; 63914; -.
DR ProteomicsDB; 83931; -. [Q9UBC1-1]
DR ProteomicsDB; 83932; -. [Q9UBC1-2]
DR Antibodypedia; 27150; 190 antibodies from 23 providers.
DR DNASU; 4795; -.
DR Ensembl; ENST00000376145.8; ENSP00000365315.4; ENSG00000204498.11. [Q9UBC1-3]
DR Ensembl; ENST00000376146.8; ENSP00000365316.4; ENSG00000204498.11. [Q9UBC1-2]
DR Ensembl; ENST00000376148.9; ENSP00000365318.4; ENSG00000204498.11. [Q9UBC1-1]
DR Ensembl; ENST00000383500.4; ENSP00000372992.4; ENSG00000206440.10.
DR Ensembl; ENST00000400279.7; ENSP00000383137.3; ENSG00000206440.10.
DR Ensembl; ENST00000400285.7; ENSP00000383142.3; ENSG00000206440.10.
DR Ensembl; ENST00000414391.6; ENSP00000414084.2; ENSG00000234530.8.
DR Ensembl; ENST00000419122.6; ENSP00000394486.2; ENSG00000234530.8.
DR Ensembl; ENST00000419623.6; ENSP00000414206.2; ENSG00000236346.8.
DR Ensembl; ENST00000421396.2; ENSP00000399871.2; ENSG00000235125.8.
DR Ensembl; ENST00000424652.6; ENSP00000395544.2; ENSG00000236346.8.
DR Ensembl; ENST00000428467.6; ENSP00000407809.2; ENSG00000236346.8.
DR Ensembl; ENST00000430501.2; ENSP00000404901.2; ENSG00000236196.8.
DR Ensembl; ENST00000430961.6; ENSP00000411174.2; ENSG00000235125.8.
DR Ensembl; ENST00000432160.6; ENSP00000411611.2; ENSG00000227565.8.
DR Ensembl; ENST00000434332.6; ENSP00000413952.2; ENSG00000234530.8.
DR Ensembl; ENST00000442947.6; ENSP00000396656.2; ENSG00000235125.8.
DR Ensembl; ENST00000451911.2; ENSP00000413643.2; ENSG00000227565.8.
DR Ensembl; ENST00000453377.6; ENSP00000395977.2; ENSG00000227565.8.
DR Ensembl; ENST00000455376.6; ENSP00000408426.2; ENSG00000236196.8.
DR Ensembl; ENST00000456607.6; ENSP00000401830.2; ENSG00000236196.8.
DR GeneID; 4795; -.
DR KEGG; hsa:4795; -.
DR MANE-Select; ENST00000376148.9; ENSP00000365318.4; NM_005007.4; NP_004998.3.
DR UCSC; uc003nub.4; human. [Q9UBC1-1]
DR CTD; 4795; -.
DR DisGeNET; 4795; -.
DR GeneCards; NFKBIL1; -.
DR HGNC; HGNC:7800; NFKBIL1.
DR HPA; ENSG00000204498; Low tissue specificity.
DR MalaCards; NFKBIL1; -.
DR MIM; 180300; phenotype.
DR MIM; 601022; gene.
DR neXtProt; NX_Q9UBC1; -.
DR OpenTargets; ENSG00000204498; -.
DR PharmGKB; PA31604; -.
DR VEuPathDB; HostDB:ENSG00000204498; -.
DR eggNOG; ENOG502QTMZ; Eukaryota.
DR GeneTree; ENSGT00390000013929; -.
DR InParanoid; Q9UBC1; -.
DR OrthoDB; 1586037at2759; -.
DR PhylomeDB; Q9UBC1; -.
DR TreeFam; TF333242; -.
DR PathwayCommons; Q9UBC1; -.
DR SignaLink; Q9UBC1; -.
DR BioGRID-ORCS; 4795; 10 hits in 1077 CRISPR screens.
DR GeneWiki; NFKBIL1; -.
DR GenomeRNAi; 4795; -.
DR Pharos; Q9UBC1; Tbio.
DR PRO; PR:Q9UBC1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UBC1; protein.
DR Bgee; ENSG00000204498; Expressed in body of pancreas and 92 other tissues.
DR ExpressionAtlas; Q9UBC1; baseline and differential.
DR Genevisible; Q9UBC1; HS.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR038753; NFKBIL1.
DR PANTHER; PTHR15263; PTHR15263; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..381
FT /note="NF-kappa-B inhibitor-like protein 1"
FT /id="PRO_0000067009"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..130
FT /note="ANK 2"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT VAR_SEQ 1..23
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041075"
FT VAR_SEQ 171..185
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046261"
FT VARIANT 224
FT /note="R -> C (in dbSNP:rs3130062)"
FT /evidence="ECO:0000269|PubMed:10369924,
FT ECO:0000269|PubMed:8081366"
FT /id="VAR_017798"
FT CONFLICT 48
FT /note="R -> Q (in Ref. 7; BAG62473)"
FT /evidence="ECO:0000305"
FT CONFLICT 238..239
FT /note="QQ -> HE (in Ref. 1; CAA54867)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 43257 MW; 1BD72901881384EC CRC64;
MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ ALLQRHPGLD
VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP DAYTDFFLPL
LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEEDDAS KEREWRQKLQ GELEDEWQEV
MGRFEGDASH ETQEPESFSA WSDRLAREHA QKCQQQQREA EGSRRPPRAE GSSQSWRQQE
EEQRLFRERA RAKEEELRES RARRAQEALG DREPKPTRAG PREEHPRGAG RGSLWRFGDV
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF RSQIETWELG
RVMGAVTALS QALNRHAEAL K
