IKBL1_MOUSE
ID IKBL1_MOUSE Reviewed; 381 AA.
AC O88995; Q91X16; Q9R1Y3;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=NF-kappa-B inhibitor-like protein 1;
DE AltName: Full=Inhibitor of kappa B-like protein;
DE Short=I-kappa-B-like protein;
DE Short=IkappaBL;
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1;
GN Name=Nfkbil1; Synonyms=Ikbl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Muscle, and Skin;
RX PubMed=10023090; DOI=10.1016/s0167-4781(98)00282-6;
RA Handel-Fernandez M.E., Vincek V.;
RT "Sequence analysis and expression of a mouse homolog of human IkappaBL
RT gene.";
RL Biochim. Biophys. Acta 1444:306-310(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the regulation of innate immune response. Acts as
CC negative regulator of Toll-like receptor and interferon-regulatory
CC factor (IRF) signaling pathways. Contributes to the negative regulation
CC of transcriptional activation of NF-kappa-B target genes in response to
CC endogenous pro-inflammatory stimuli (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CACTIN (via N-terminal domain); the interaction
CC occurs in a pro-inflammatory-independent manner. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclear localization
CC with a speckled expression pattern in some cells. Colocalizes with
CC CACTIN in the nucleus (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: High expression found in heart muscle, liver,
CC kidney and skin. Not detected in spleen, lung and brain.
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DR EMBL; AF095902; AAC64292.1; -; mRNA.
DR EMBL; AC007080; AAD30175.1; -; Genomic_DNA.
DR EMBL; AF109719; AAC82486.1; -; Genomic_DNA.
DR EMBL; BC013269; AAH13269.1; -; mRNA.
DR CCDS; CCDS28693.1; -.
DR RefSeq; NP_035039.1; NM_010909.4.
DR AlphaFoldDB; O88995; -.
DR SMR; O88995; -.
DR BioGRID; 201756; 1.
DR STRING; 10090.ENSMUSP00000035452; -.
DR PhosphoSitePlus; O88995; -.
DR PaxDb; O88995; -.
DR PRIDE; O88995; -.
DR ProteomicsDB; 269548; -.
DR Antibodypedia; 27150; 190 antibodies from 23 providers.
DR DNASU; 18038; -.
DR Ensembl; ENSMUST00000048994; ENSMUSP00000035452; ENSMUSG00000042419.
DR GeneID; 18038; -.
DR KEGG; mmu:18038; -.
DR UCSC; uc008cgv.1; mouse.
DR CTD; 4795; -.
DR MGI; MGI:1340031; Nfkbil1.
DR VEuPathDB; HostDB:ENSMUSG00000042419; -.
DR eggNOG; ENOG502QTMZ; Eukaryota.
DR GeneTree; ENSGT00390000013929; -.
DR HOGENOM; CLU_054217_0_0_1; -.
DR InParanoid; O88995; -.
DR OMA; DEFCETF; -.
DR OrthoDB; 1586037at2759; -.
DR PhylomeDB; O88995; -.
DR TreeFam; TF333242; -.
DR BioGRID-ORCS; 18038; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Nfkbil1; mouse.
DR PRO; PR:O88995; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; O88995; protein.
DR Bgee; ENSMUSG00000042419; Expressed in granulocyte and 188 other tissues.
DR Genevisible; O88995; MM.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IDA:MGI.
DR GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR038753; NFKBIL1.
DR PANTHER; PTHR15263; PTHR15263; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..381
FT /note="NF-kappa-B inhibitor-like protein 1"
FT /id="PRO_0000067011"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..134
FT /note="ANK 2"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBC1"
FT CONFLICT 219
FT /note="E -> Q (in Ref. 3; AAH13269)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 43202 MW; 57BD313987CDE868 CRC64;
MSNPSPQAPE EEASTSVCRP QSCSMASASR RHRRERRFRR YLSAGRLVRA QALLQRHPGL
DVDAGQPPPL HRACARHDAP ALCLLLRLGA DPAHQDRHGD TALHAAARQG PDAYTDFFLP
LLSRCPSAMG IKNKDGETPG QILGWGPPWD SAEEEEDEEV SKEREWRQKL QGELEDEWQE
VIGRFEDDAS RDTQEPESFS AWSERLAREH AQKQRQQLEA EGSCRPPRAE GSSHSWRQHE
EEQRLFRERA RAKEKELCES RARRAQEAQR DKGPEPPRAG PRAEHPRGAE RGSLWRFGDV
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL KRYLRVQQVR WHPDRFLQRF RSQIETWELG
RVMGAVTALS QALNRHAEAL K
