IKBL1_PANTR
ID IKBL1_PANTR Reviewed; 380 AA.
AC Q861W0; Q1XHZ0;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=NF-kappa-B inhibitor-like protein 1;
DE AltName: Full=Inhibitor of kappa B-like protein;
DE Short=I-kappa-B-like protein;
DE Short=IkappaBL;
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1;
GN Name=NFKBIL1; Synonyms=IKBL;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12493009; DOI=10.1034/j.1600-065x.2002.19008.x;
RA Kulski J.K., Shiina T., Anzai T., Kohara S., Inoko H.;
RT "Comparative genomic analysis of the MHC: the evolution of class I
RT duplication blocks, diversity and complexity from shark to man.";
RL Immunol. Rev. 190:95-122(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A.,
RA Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT "Comparative sequencing of human and chimpanzee MHC class I regions unveils
RT insertions/deletions as the major path to genomic divergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
CC -!- FUNCTION: Involved in the regulation of innate immune response. Acts as
CC negative regulator of Toll-like receptor and interferon-regulatory
CC factor (IRF) signaling pathways. Contributes to the negative regulation
CC of transcriptional activation of NF-kappa-B target genes in response to
CC endogenous pro-inflammatory stimuli (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CACTIN (via N-terminal domain); the interaction
CC occurs in a pro-inflammatory-independent manner. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclear localization
CC with a speckled expression pattern in some cells. Colocalizes with
CC CACTIN in the nucleus (By similarity). {ECO:0000250}.
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DR EMBL; AB054536; BAB83884.1; -; Genomic_DNA.
DR EMBL; BA000041; BAC78159.1; -; Genomic_DNA.
DR EMBL; AB210169; BAE92777.1; -; Genomic_DNA.
DR EMBL; AB210170; BAE92780.1; -; Genomic_DNA.
DR RefSeq; NP_001038972.1; NM_001045507.1.
DR AlphaFoldDB; Q861W0; -.
DR SMR; Q861W0; -.
DR STRING; 9598.ENSPTRP00000054519; -.
DR PaxDb; Q861W0; -.
DR GeneID; 462558; -.
DR KEGG; ptr:462558; -.
DR CTD; 4795; -.
DR eggNOG; ENOG502QTMZ; Eukaryota.
DR InParanoid; Q861W0; -.
DR OrthoDB; 1586037at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR038753; NFKBIL1.
DR PANTHER; PTHR15263; PTHR15263; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
PE 3: Inferred from homology;
KW ANK repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..380
FT /note="NF-kappa-B inhibitor-like protein 1"
FT /id="PRO_0000067012"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..133
FT /note="ANK 2"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBC1"
FT CONFLICT 19
FT /note="R -> Q (in Ref. 3; BAE92777/BAE92780)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="D -> A (in Ref. 3; BAE92777/BAE92780)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 43135 MW; 22B644D09AF1041C CRC64;
MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ ALLQRHPGLD
VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP DAYTDFFLPL
LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEDDASK EREWRQKLQG ELEDEWQEVM
GRFEGDASHE TQEPESFSAW SDRLAREHAQ KYQQQQREAE GSCRPPRAEG SSQSWRQQEE
EQRLFRERAR AKEEELRESR ARRAQEALGD REPKPTRAGP REEHPRGAGR GSLWRFGDVP
WPCPGGGDPE AMAAALVARG PPLEEQGALR RYLRVQQVRW HPDRFLQRFR SQIETWELGR
VMGAVTALSQ ALNRHAEALK
