IKBL1_RAT
ID IKBL1_RAT Reviewed; 381 AA.
AC Q8R2H1; Q499T4;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=NF-kappa-B inhibitor-like protein 1;
DE AltName: Full=Inhibitor of kappa B-like protein;
DE Short=I-kappa-B-like protein;
DE Short=IkappaBL;
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1;
GN Name=Nfkbil1; Synonyms=Ikbl;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-110.
RC STRAIN=Lewis;
RX PubMed=11904681; DOI=10.1007/s00251-001-0428-2;
RA Lambracht-Washington D., Fischer Lindahl K.;
RT "Does the rat have an H2-D orthologue next to Bat1?";
RL Immunogenetics 53:1039-1046(2002).
CC -!- FUNCTION: Involved in the regulation of innate immune response. Acts as
CC negative regulator of Toll-like receptor and interferon-regulatory
CC factor (IRF) signaling pathways. Contributes to the negative regulation
CC of transcriptional activation of NF-kappa-B target genes in response to
CC endogenous pro-inflammatory stimuli (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CACTIN (via N-terminal domain); the interaction
CC occurs in a pro-inflammatory-independent manner. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclear localization
CC with a speckled expression pattern in some cells. Colocalizes with
CC CACTIN in the nucleus (By similarity). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL98918.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX883046; CAE84005.1; -; Genomic_DNA.
DR EMBL; BC099772; AAH99772.1; -; mRNA.
DR EMBL; AF387339; AAL98918.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_997674.1; NM_212509.2.
DR AlphaFoldDB; Q8R2H1; -.
DR SMR; Q8R2H1; -.
DR STRING; 10116.ENSRNOP00000001113; -.
DR PaxDb; Q8R2H1; -.
DR Ensembl; ENSRNOT00000001113; ENSRNOP00000001113; ENSRNOG00000000839.
DR GeneID; 361794; -.
DR KEGG; rno:361794; -.
DR UCSC; RGD:1303310; rat.
DR CTD; 4795; -.
DR RGD; 1303310; Nfkbil1.
DR eggNOG; ENOG502QTMZ; Eukaryota.
DR GeneTree; ENSGT00390000013929; -.
DR HOGENOM; CLU_054217_0_0_1; -.
DR InParanoid; Q8R2H1; -.
DR OMA; DEFCETF; -.
DR OrthoDB; 1586037at2759; -.
DR PhylomeDB; Q8R2H1; -.
DR TreeFam; TF333242; -.
DR PRO; PR:Q8R2H1; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000839; Expressed in testis and 20 other tissues.
DR ExpressionAtlas; Q8R2H1; baseline and differential.
DR Genevisible; Q8R2H1; RN.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR038753; NFKBIL1.
DR PANTHER; PTHR15263; PTHR15263; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..381
FT /note="NF-kappa-B inhibitor-like protein 1"
FT /id="PRO_0000067014"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..133
FT /note="ANK 2"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBC1"
SQ SEQUENCE 381 AA; 43293 MW; 21C415DEA6F9617B CRC64;
MSNPSPQAPE EEASTSVCRP QSSMASVSRR HRRERRFRRY LSAGRLVRAQ ALLQRHPGLD
VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP NAYTDFFLPL
LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEDEEVS KEREWRQKLQ GELEDEWQEV
IGRFEDDASR ETQEPESFSA WSERLAREHA QKQRRQQLEA EGSRRPPRAE GSSHSWRQQE
EEQRLFRERA RVKEKELCES RARRAQEAQG DRGPAPPRAR PRAEHPRGAG RGSLWRFGDV
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL KRYLRVQQVR WHPDRFLQRF RNQIETWELG
RVMGAVTALS QALNRHAEAL K
