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IKBZ_BOVIN
ID   IKBZ_BOVIN              Reviewed;         719 AA.
AC   Q9BE45; A7Z059;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=NF-kappa-B inhibitor zeta;
DE   AltName: Full=I-kappa-B-zeta;
DE            Short=IkB-zeta;
DE            Short=IkappaBzeta;
DE   AltName: Full=Molecule possessing ankyrin repeats induced by lipopolysaccharide {ECO:0000303|PubMed:15010226};
DE            Short=MAIL {ECO:0000303|PubMed:15010226};
GN   Name=NFKBIZ; Synonyms=MAIL {ECO:0000303|PubMed:15010226};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=Holstein; TISSUE=Blood;
RX   PubMed=15010226; DOI=10.1016/j.vetimm.2003.12.004;
RA   Yamaji D., Kitamura H., Kimura K., Matsushita Y., Okada H., Shiina T.,
RA   Morimatsu M., Saito M.;
RT   "Cloning of bovine MAIL and its mRNA expression in white blood cells of
RT   Holstein cows.";
RL   Vet. Immunol. Immunopathol. 98:175-184(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in regulation of NF-kappa-B transcription factor
CC       complexes. Inhibits NF-kappa-B activity without affecting its nuclear
CC       translocation upon stimulation. Inhibits DNA-binding of RELA and
CC       NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B
CC       p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated
CC       transcription (By similarity). In vitro, upon association with
CC       NFKB1/p50 has transcriptional activation activity and, together with
CC       NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes
CC       transcription of LCN2 and DEFB4 (By similarity). Is recruited to IL-6
CC       promoters and activates IL-6 but decreases TNF-alpha production in
CC       response to LPS. Seems to be involved in the induction of inflammatory
CC       genes activated through TLR/IL-1 receptor signaling. Involved in the
CC       induction of T helper 17 cells (Th17) differentiation upon recognition
CC       of antigen by T cell antigen receptor (TCR) (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BYH8, ECO:0000250|UniProtKB:Q9EST8}.
CC   -!- SUBUNIT: Interacts with NFKB1/p50 (By similarity). Interacts with RELA
CC       (By similarity). Interacts with AKIRIN2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BYH8, ECO:0000250|UniProtKB:Q9EST8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST8}.
CC   -!- INDUCTION: By LPS in polymorphonuclear cells, monocytes/macrophages and
CC       total lymphocytes, but not in T-lymphocytes (in vitro). By E.coli
CC       intramammary injection in peripheral blood leukocytes.
CC       {ECO:0000269|PubMed:15010226}.
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DR   EMBL; AB058410; BAB39767.1; -; mRNA.
DR   EMBL; BC153257; AAI53258.1; -; mRNA.
DR   RefSeq; NP_777151.1; NM_174726.1.
DR   AlphaFoldDB; Q9BE45; -.
DR   SMR; Q9BE45; -.
DR   STRING; 9913.ENSBTAP00000014591; -.
DR   PaxDb; Q9BE45; -.
DR   Ensembl; ENSBTAT00000014591; ENSBTAP00000014591; ENSBTAG00000010987.
DR   GeneID; 282713; -.
DR   KEGG; bta:282713; -.
DR   CTD; 64332; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010987; -.
DR   VGNC; VGNC:32050; NFKBIZ.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000153695; -.
DR   HOGENOM; CLU_030240_0_0_1; -.
DR   InParanoid; Q9BE45; -.
DR   OMA; LQRNQQH; -.
DR   OrthoDB; 867160at2759; -.
DR   TreeFam; TF330224; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000010987; Expressed in ureter and 104 other tissues.
DR   ExpressionAtlas; Q9BE45; baseline and differential.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:2000321; P:positive regulation of T-helper 17 cell differentiation; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   Activator; ANK repeat; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..719
FT                   /note="NF-kappa-B inhibitor zeta"
FT                   /id="PRO_0000323576"
FT   REPEAT          444..473
FT                   /note="ANK 1"
FT   REPEAT          480..509
FT                   /note="ANK 2"
FT   REPEAT          513..542
FT                   /note="ANK 3"
FT   REPEAT          552..581
FT                   /note="ANK 4"
FT   REPEAT          583..608
FT                   /note="ANK 5"
FT   REPEAT          613..642
FT                   /note="ANK 6"
FT   REPEAT          649..682
FT                   /note="ANK 7"
FT   REGION          46..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..394
FT                   /note="Required for transcriptional activity"
FT                   /evidence="ECO:0000250"
FT   REGION          405..719
FT                   /note="Interaction with NFKB1/p50"
FT                   /evidence="ECO:0000250"
FT   MOTIF           164..179
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        58..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        236
FT                   /note="Q -> H (in Ref. 1; BAB39767)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        244..248
FT                   /note="EVPQG -> QSLRL (in Ref. 1; BAB39767)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   719 AA;  78239 MW;  D8490551E5AC2816 CRC64;
     MIVDKLLDDS RGGEGLLDAA GDCGLMTSPL NLAYFYGASP PAAAPGACDG GCSASGPSAP
     GSPGSDSSDF SSASSVSSCG AVESRPRGGA RAERLQVEPH MGVVRQQRGP FQGVRVKNSV
     KELLLHIRSH KQKASGQAVD DFKTQSVNRE QFTELKNTVS YSGKRKGSDS LSDGPACKRS
     ALLHTQFLTP PQTPTPAESM EDVHHNESKQ DSCADLLQNI INIKNECSPV SLNTVQVSWM
     SPGEVPQGSP HEQCQDLHRG QVFSPPQKYQ PFQVSSSPHM MDQASMYQYS PQNQSVQPPP
     QHYTHNPALE YSPYSRTSQS PSYEPHLFGR EPQFCPDQSF APLLSDPRQS ENIAVPPQTA
     PSVQQQIDTH LQNFSLMPPD TCEALARPDA SSTPLSTPLP FPNLGGNPMS TTQLGKSFFQ
     WQVEQEENKL ANISQDQFLS KDADGDTFLH IAVAQGRRAL SYVLARKMNA LHMLDIKEHN
     GQSAFQVAVA ANQHLIVQDL VTLGAQVNTT DCWGRTPLHV CAEKGHSQVL QAIQKGAAGS
     NQFVDLEATN YDGLTPLHCA VLAHNAVVHE LQRNQQPHSP EVQELLLKNK SLVDTIKCLI
     QMGAAVEAKD RKSGRTALHL AAEEANLELI RLFLELPSCL SFVNAKAYNG NTALHVAASL
     QYRVTQLDAV RLLMRKGADP STRNLENEQP VHLVPDGPVG EQIRRILKGK SIQQRAPPY
 
 
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