IKBZ_BOVIN
ID IKBZ_BOVIN Reviewed; 719 AA.
AC Q9BE45; A7Z059;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=NF-kappa-B inhibitor zeta;
DE AltName: Full=I-kappa-B-zeta;
DE Short=IkB-zeta;
DE Short=IkappaBzeta;
DE AltName: Full=Molecule possessing ankyrin repeats induced by lipopolysaccharide {ECO:0000303|PubMed:15010226};
DE Short=MAIL {ECO:0000303|PubMed:15010226};
GN Name=NFKBIZ; Synonyms=MAIL {ECO:0000303|PubMed:15010226};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=Holstein; TISSUE=Blood;
RX PubMed=15010226; DOI=10.1016/j.vetimm.2003.12.004;
RA Yamaji D., Kitamura H., Kimura K., Matsushita Y., Okada H., Shiina T.,
RA Morimatsu M., Saito M.;
RT "Cloning of bovine MAIL and its mRNA expression in white blood cells of
RT Holstein cows.";
RL Vet. Immunol. Immunopathol. 98:175-184(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in regulation of NF-kappa-B transcription factor
CC complexes. Inhibits NF-kappa-B activity without affecting its nuclear
CC translocation upon stimulation. Inhibits DNA-binding of RELA and
CC NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B
CC p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated
CC transcription (By similarity). In vitro, upon association with
CC NFKB1/p50 has transcriptional activation activity and, together with
CC NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes
CC transcription of LCN2 and DEFB4 (By similarity). Is recruited to IL-6
CC promoters and activates IL-6 but decreases TNF-alpha production in
CC response to LPS. Seems to be involved in the induction of inflammatory
CC genes activated through TLR/IL-1 receptor signaling. Involved in the
CC induction of T helper 17 cells (Th17) differentiation upon recognition
CC of antigen by T cell antigen receptor (TCR) (By similarity).
CC {ECO:0000250|UniProtKB:Q9BYH8, ECO:0000250|UniProtKB:Q9EST8}.
CC -!- SUBUNIT: Interacts with NFKB1/p50 (By similarity). Interacts with RELA
CC (By similarity). Interacts with AKIRIN2 (By similarity).
CC {ECO:0000250|UniProtKB:Q9BYH8, ECO:0000250|UniProtKB:Q9EST8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST8}.
CC -!- INDUCTION: By LPS in polymorphonuclear cells, monocytes/macrophages and
CC total lymphocytes, but not in T-lymphocytes (in vitro). By E.coli
CC intramammary injection in peripheral blood leukocytes.
CC {ECO:0000269|PubMed:15010226}.
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DR EMBL; AB058410; BAB39767.1; -; mRNA.
DR EMBL; BC153257; AAI53258.1; -; mRNA.
DR RefSeq; NP_777151.1; NM_174726.1.
DR AlphaFoldDB; Q9BE45; -.
DR SMR; Q9BE45; -.
DR STRING; 9913.ENSBTAP00000014591; -.
DR PaxDb; Q9BE45; -.
DR Ensembl; ENSBTAT00000014591; ENSBTAP00000014591; ENSBTAG00000010987.
DR GeneID; 282713; -.
DR KEGG; bta:282713; -.
DR CTD; 64332; -.
DR VEuPathDB; HostDB:ENSBTAG00000010987; -.
DR VGNC; VGNC:32050; NFKBIZ.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000153695; -.
DR HOGENOM; CLU_030240_0_0_1; -.
DR InParanoid; Q9BE45; -.
DR OMA; LQRNQQH; -.
DR OrthoDB; 867160at2759; -.
DR TreeFam; TF330224; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000010987; Expressed in ureter and 104 other tissues.
DR ExpressionAtlas; Q9BE45; baseline and differential.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:2000321; P:positive regulation of T-helper 17 cell differentiation; ISS:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 2: Evidence at transcript level;
KW Activator; ANK repeat; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..719
FT /note="NF-kappa-B inhibitor zeta"
FT /id="PRO_0000323576"
FT REPEAT 444..473
FT /note="ANK 1"
FT REPEAT 480..509
FT /note="ANK 2"
FT REPEAT 513..542
FT /note="ANK 3"
FT REPEAT 552..581
FT /note="ANK 4"
FT REPEAT 583..608
FT /note="ANK 5"
FT REPEAT 613..642
FT /note="ANK 6"
FT REPEAT 649..682
FT /note="ANK 7"
FT REGION 46..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..394
FT /note="Required for transcriptional activity"
FT /evidence="ECO:0000250"
FT REGION 405..719
FT /note="Interaction with NFKB1/p50"
FT /evidence="ECO:0000250"
FT MOTIF 164..179
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 58..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 236
FT /note="Q -> H (in Ref. 1; BAB39767)"
FT /evidence="ECO:0000305"
FT CONFLICT 244..248
FT /note="EVPQG -> QSLRL (in Ref. 1; BAB39767)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 719 AA; 78239 MW; D8490551E5AC2816 CRC64;
MIVDKLLDDS RGGEGLLDAA GDCGLMTSPL NLAYFYGASP PAAAPGACDG GCSASGPSAP
GSPGSDSSDF SSASSVSSCG AVESRPRGGA RAERLQVEPH MGVVRQQRGP FQGVRVKNSV
KELLLHIRSH KQKASGQAVD DFKTQSVNRE QFTELKNTVS YSGKRKGSDS LSDGPACKRS
ALLHTQFLTP PQTPTPAESM EDVHHNESKQ DSCADLLQNI INIKNECSPV SLNTVQVSWM
SPGEVPQGSP HEQCQDLHRG QVFSPPQKYQ PFQVSSSPHM MDQASMYQYS PQNQSVQPPP
QHYTHNPALE YSPYSRTSQS PSYEPHLFGR EPQFCPDQSF APLLSDPRQS ENIAVPPQTA
PSVQQQIDTH LQNFSLMPPD TCEALARPDA SSTPLSTPLP FPNLGGNPMS TTQLGKSFFQ
WQVEQEENKL ANISQDQFLS KDADGDTFLH IAVAQGRRAL SYVLARKMNA LHMLDIKEHN
GQSAFQVAVA ANQHLIVQDL VTLGAQVNTT DCWGRTPLHV CAEKGHSQVL QAIQKGAAGS
NQFVDLEATN YDGLTPLHCA VLAHNAVVHE LQRNQQPHSP EVQELLLKNK SLVDTIKCLI
QMGAAVEAKD RKSGRTALHL AAEEANLELI RLFLELPSCL SFVNAKAYNG NTALHVAASL
QYRVTQLDAV RLLMRKGADP STRNLENEQP VHLVPDGPVG EQIRRILKGK SIQQRAPPY