ID   IKIP_BOVIN              Reviewed;         349 AA.
AC   A2VE53;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Inhibitor of nuclear factor kappa-B kinase-interacting protein;
DE            Short=I kappa-B kinase-interacting protein;
DE            Short=IKBKB-interacting protein;
DE            Short=IKK-interacting protein;
GN   Name=IKBIP; Synonyms=IKIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Target of p53/TP53 with pro-apoptotic function.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2
CC       genes are transcribed in opposite directions.
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DR   EMBL; BC133577; AAI33578.1; -; mRNA.
DR   RefSeq; NP_001075205.1; NM_001081736.2.
DR   AlphaFoldDB; A2VE53; -.
DR   SMR; A2VE53; -.
DR   STRING; 9913.ENSBTAP00000028864; -.
DR   PaxDb; A2VE53; -.
DR   PRIDE; A2VE53; -.
DR   Ensembl; ENSBTAT00000028864; ENSBTAP00000028864; ENSBTAG00000021660.
DR   GeneID; 540640; -.
DR   KEGG; bta:540640; -.
DR   CTD; 121457; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021660; -.
DR   VGNC; VGNC:56209; IKBIP.
DR   eggNOG; ENOG502RXG3; Eukaryota.
DR   GeneTree; ENSGT00500000045001; -.
DR   HOGENOM; CLU_061486_0_0_1; -.
DR   InParanoid; A2VE53; -.
DR   OMA; EKTWNLM; -.
DR   OrthoDB; 1191353at2759; -.
DR   TreeFam; TF331715; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000021660; Expressed in caput epididymis and 105 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR024152; Inh_kappa-B_kinase-int.
DR   PANTHER; PTHR21734; PTHR21734; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..349
FT                   /note="Inhibitor of nuclear factor kappa-B kinase-
FT                   interacting protein"
FT                   /id="PRO_0000342260"
FT   TRANSMEM        45..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          183..216
FT                   /evidence="ECO:0000255"
FT   COILED          304..347
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        327
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   349 AA;  39216 MW;  E14FF05A6A297270 CRC64;
     MSEVKSRKKS GTKGAPAEPG KRNEGGKSPE ARGGGGRGWA DPRTGVSLLS LGTCLGLAWF
     VFQQSEKFAK VENQYQLLKM ETSEFQGLQS KISLISEKCQ KSEAIIEQLK AFQIITHLKH
     LQEEIYEVKT WSSRISEKQD ILNNNLTTVS QDVAKADQST TSMAKDIGLK ITTIKTDIRR
     MSGLVTDVTS LTDSVQELEN KIEKVEKNTV KNIGDLLSSS IDRTAMLRKT ASENSQRINS
     VKKILSELQG DFNKHTDRLL SLESDRAKVL KTVTFANDLK PKVYNLKKDF SRLEPLVNDL
     TLRIGRLVTD LQQREKEIAF LKEKISNLTT VRAEIKDMKD EIKHISDMD