IKIP_RAT
ID IKIP_RAT Reviewed; 373 AA.
AC Q5EAJ6; Q5M859;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Inhibitor of nuclear factor kappa-B kinase-interacting protein;
DE Short=I kappa-B kinase-interacting protein;
DE Short=IKBKB-interacting protein;
DE Short=IKK-interacting protein;
GN Name=Ikbip; Synonyms=Ikip;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15389287; DOI=10.1038/sj.cdd.4401502;
RA Hofer-Warbinek R., Schmid J.A., Mayer H., Winsauer G., Orel L., Mueller B.,
RA Wiesner C., Binder B.R., de Martin R.;
RT "A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene
RT locus, is regulated by p53.";
RL Cell Death Differ. 11:1317-1325(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Target of p53/TP53 with pro-apoptotic function.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Ikip1;
CC IsoId=Q5EAJ6-1; Sequence=Displayed;
CC Name=2; Synonyms=Ikip2;
CC IsoId=Q5EAJ6-2; Sequence=VSP_034412;
CC -!- PTM: N-glycosylated at Asn-151. {ECO:0000250}.
CC -!- MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2
CC genes are transcribed in opposite directions.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BN000112; CAD62384.1; -; mRNA.
DR EMBL; BN000113; CAD62385.1; -; mRNA.
DR EMBL; BC088210; AAH88210.1; -; mRNA.
DR RefSeq; NP_001009430.2; NM_001009430.2. [Q5EAJ6-1]
DR RefSeq; XP_006241312.1; XM_006241250.3. [Q5EAJ6-2]
DR AlphaFoldDB; Q5EAJ6; -.
DR SMR; Q5EAJ6; -.
DR BioGRID; 260816; 1.
DR STRING; 10116.ENSRNOP00000010913; -.
DR GlyGen; Q5EAJ6; 1 site.
DR jPOST; Q5EAJ6; -.
DR PaxDb; Q5EAJ6; -.
DR PRIDE; Q5EAJ6; -.
DR Ensembl; ENSRNOT00000010914; ENSRNOP00000010913; ENSRNOG00000008247. [Q5EAJ6-1]
DR Ensembl; ENSRNOT00000010929; ENSRNOP00000010929; ENSRNOG00000008247. [Q5EAJ6-2]
DR GeneID; 314730; -.
DR KEGG; rno:314730; -.
DR UCSC; RGD:1305457; rat. [Q5EAJ6-1]
DR CTD; 121457; -.
DR RGD; 1305457; Ikbip.
DR eggNOG; ENOG502RXC3; Eukaryota.
DR GeneTree; ENSGT00500000045001; -.
DR HOGENOM; CLU_061486_1_0_1; -.
DR InParanoid; Q5EAJ6; -.
DR OMA; EKTWNLM; -.
DR OrthoDB; 1191353at2759; -.
DR PhylomeDB; Q5EAJ6; -.
DR TreeFam; TF331715; -.
DR PRO; PR:Q5EAJ6; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000008247; Expressed in ovary and 19 other tissues.
DR Genevisible; Q5EAJ6; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:HGNC-UCL.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR024152; Inh_kappa-B_kinase-int.
DR PANTHER; PTHR21734; PTHR21734; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Endoplasmic reticulum; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..373
FT /note="Inhibitor of nuclear factor kappa-B kinase-
FT interacting protein"
FT /id="PRO_0000342263"
FT TRANSMEM 43..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..257
FT /evidence="ECO:0000255"
FT COILED 290..325
FT /evidence="ECO:0000255"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 97..373
FT /note="LESTENTLQEATSSMSLMTQFEQEVAGLQRSIHDIENSEEMLTQKLQNLNEK
FT FQNITDLWKRTLVEMSDNTAVFKSEAKSTHSEVTLKINSAEQEIKLLTERLKDLEDSTL
FT RNIRTVSRQEEEDLLRVEAQLSSDTKAVEKLEEEQRTLLARDEDLTDKLSSYEPKVEEC
FT KAHLPTIENAVHSVLRVSQDLIGTERKMEELTVQMFNMEDDMLKAVSEIMEMQNTLEGI
FT QYDNSLLKMQNELVVLKGKVHDFMAYSSAGEKGTLEEYNLENKGTDDY -> YQKCEAL
FT LEQLKAFQIVAHLKLLQEEIHGMKTWSIGITEKQKILNNTLTSLSEDIIKVDQGTASVA
FT KDMGLKITSVKTDVRRISGLVTEVESLTDAVQALENKVKKVETATVESIGDLLSSSIDR
FT TTALRKTASENSRRIDSVTKRLAELQGDFDEHTDRFLSLESERAKVLKAVSFANDLKPK
FT VYNLKKDFSRLEPLVNDLTLRIGRLGSDLMQREKEIASLKEKISNLTIVQAAIKDMKDE
FT ITHISG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15389287,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_034412"
SQ SEQUENCE 373 AA; 42361 MW; C6BA554B510E4E38 CRC64;
MSEVKSRKKP GPKVAAPEPE KRSDGRKNPE ARGGAGWADP RTGLSLLSLA TSLGLAWLVF
QQSEKFAKVE NQYRLLQTES SEFQGLQSKI SLISNKLEST ENTLQEATSS MSLMTQFEQE
VAGLQRSIHD IENSEEMLTQ KLQNLNEKFQ NITDLWKRTL VEMSDNTAVF KSEAKSTHSE
VTLKINSAEQ EIKLLTERLK DLEDSTLRNI RTVSRQEEED LLRVEAQLSS DTKAVEKLEE
EQRTLLARDE DLTDKLSSYE PKVEECKAHL PTIENAVHSV LRVSQDLIGT ERKMEELTVQ
MFNMEDDMLK AVSEIMEMQN TLEGIQYDNS LLKMQNELVV LKGKVHDFMA YSSAGEKGTL
EEYNLENKGT DDY
