IKZF1_CHICK
ID IKZF1_CHICK Reviewed; 518 AA.
AC O42410;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=DNA-binding protein Ikaros;
DE AltName: Full=Ikaros family zinc finger protein 1;
GN Name=IKZF1; Synonyms=IK, IKAROS, ZNFN1A1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=H.B2; TISSUE=Thymus;
RX PubMed=9295018; DOI=10.1002/eji.1830270806;
RA Liippo J., Lassila O.;
RT "Avian Ikaros gene is expressed early in embryogenesis.";
RL Eur. J. Immunol. 27:1853-1857(1997).
CC -!- FUNCTION: Binds and activates the enhancer (delta-A element) of the
CC CD3-delta gene. Functions in the specification and the maturation of
CC the T-lymphocyte. Also interacts with a critical control element in the
CC TDT (terminal deoxynucleotidyltransferase) promoter as well as with the
CC promoters for other genes expressed during early stages of B- and T-
CC cell development. Function is isoform-specific and is modulated by
CC dominant-negative inactive isoforms (By similarity).
CC {ECO:0000250|UniProtKB:Q03267, ECO:0000250|UniProtKB:Q13422}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13422}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.;
CC Name=1;
CC IsoId=O42410-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in embryonic hematopoietic organs such as
CC the bursa of Fabricius, thymus and spleen. In the adult, expressed in
CC spleen, thymus, bursa and peripheral blood leukocytes.
CC {ECO:0000269|PubMed:9295018}.
CC -!- DEVELOPMENTAL STAGE: Expressed early in embryo from embryonic day 2
CC onwards. {ECO:0000269|PubMed:9295018}.
CC -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; Y11833; CAA72531.1; -; mRNA.
DR RefSeq; NP_990419.1; NM_205088.1. [O42410-1]
DR AlphaFoldDB; O42410; -.
DR SMR; O42410; -.
DR STRING; 9031.ENSGALP00000021333; -.
DR PaxDb; O42410; -.
DR GeneID; 395974; -.
DR KEGG; gga:395974; -.
DR CTD; 10320; -.
DR VEuPathDB; HostDB:geneid_395974; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; O42410; -.
DR OrthoDB; 385551at2759; -.
DR PhylomeDB; O42410; -.
DR PRO; PR:O42410; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0032993; C:protein-DNA complex; IDA:AgBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:AgBase.
DR GO; GO:0016049; P:cell growth; TAS:AgBase.
DR GO; GO:0002377; P:immunoglobulin production; TAS:AgBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:AgBase.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:AgBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..518
FT /note="DNA-binding protein Ikaros"
FT /id="PRO_0000047096"
FT ZN_FING 117..139
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 145..167
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..224
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..483
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 489..513
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57586 MW; 4DF15B677E616135 CRC64;
METDEAQDMS QVSGKESPPI SDVPDDADEP MPVPEDLSTT TGGQQSVKNE RVLAGNIKIE
TQSDEENGRA CEMNGEECAE DLRMLDASGD KMNGSHNGPG SKAMSGVGGI RLPNGKLKCD
ICGIICIGPN VLMVHNRSHT GERPFQCNQC GASFTQKGNL LRHIKLHSGE KPFKCHLCNY
ACRRRDALTG HLRTHSVGKP HKCGYCGRSY KQRSSLEEHK ERCHNYLQTM SISSNLYSVI
KEETNQSEMA EDLCKIGSER SLVLDRLASN VAKRKSSMPQ KFVGEKCLSD LPYDATTNYE
KENEIMQTHV IDQAINNAIS YLGAESLRPL VQTPPVGSEV VPVISPMYQL HKPLGDNQTR
SNHTAQDSAV ENLLLLSKAK SVSSERDASP SNSCQDSTDT ESNNEERSGL IYLTNHIGPH
ARNGISVKEE SRQFDVLRAG TDNSQDAFKV ISSNGEQVRV YKCEHCRVLF LDHVMYTIHM
GCHGFRDPFE CNMCGYHSQD RYEFSSHITR GEHRFHMS
